Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study

Stewart, Christopher J.; Nelson, Andrew; Campbell, Matthew D.; Walker, Mark; Stevenson, Emma; Shaw, James; Cummings, Stephen; West, Daniel J.

doi:10.1111/dme.13140

Cited by 53 publications

(37 citation statements)

References 22 publications

(31 reference statements)

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“…An observational study showed that gut microbiota of long-standing T1D patients with good glycemic control and high physical fitness is similar to matched-people without diabetes [128]: bacterial profiles of ten male young adults with T1D were comparable with those of the ten paired-controls. Importantly, this effect persisted even when the analysis accounted for the HbA1c stratification.…”

Section: After Normalizing Bmi Diet Age Estaki Et Al Analyzed Fecmentioning

confidence: 99%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

128

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Please cite this article as: Codella Roberto, Luzi Livio, Terruzzi Ileana.Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases.Digestive and Liver Disease https://doi.org/10.1016/j.dld. 2017.11.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractLimited animal and human research findings implied that exercise might have a

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Section: After Normalizing Bmi Diet Age Estaki Et Al Analyzed Fecmentioning

confidence: 99%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

128

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“…Intestinal dysbiosis has been demonstrated to be associated with inflammatory bowel disease (IBD) [3,4], irritable bowel syndrome [5], and nonsteroidal anti-inflammatory drugs-induced enteropathy [6]. Moreover, gut dysbiosis has been reported in patients with types 1 and 2 diabetes [7,8], multiple sclerosis [9], autism [10], and rheumatoid arthritis [11]. …”

Section: Introductionmentioning

confidence: 99%

Intestinal Dysbiosis Secondary to Proton-Pump Inhibitor Use

Naito

Kashiwagi²,

Takagi³

et al. 2018

Digestion

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Background: Gut dysbiosis associated with the use of proton-pump inhibitors (PPIs) has been found to lead to the occurrence of infectious and inflammatory adverse events. A longitudinal observational cohort study has demonstrated the heightened risk of death associated with PPI use. Summary: We evaluated meta-analyses to determine the association between PPI use and infectious and inflammatory diseases. Meta-analyses showed that PPI use is a potential risk for the development of enteric infections caused by Clostridium difficile, as well as small intestinal bacterial overgrowth, spontaneous bacterial peritonitis, community-acquired pneumonia, hepatic encephalopathy, and adverse outcomes in inflammatory bowel disease. We also examined changes in the composition and function of the gut microbiota with the use of PPIs. PPI use significantly increased the presence of Streptococcaceae and Enterococcaceae, which are risk factors for C. difficile infection, and decreased that of Faecalibacterium, a commensal anti-inflammatory microorganism. Key Message: High-throughput, microbial 16S rRNA gene sequencing has allowed us to investigate the association between the gut microbiome and PPI use. Future prospective comparison studies are necessary to confirm this association, and to develop new strategies to prevent complications of PPI use

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“…9,11,12,48,57,[59][60][61]63,68,70,[75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93].Exercise and microbiota. Enterobacteriaceae and ↑ Bifidobacterium spp Bifidobacterium spp.…”

mentioning

confidence: 99%

Mutual Interactions among Exercise, Sport Supplements and Microbiota

et al. 2019

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The adult gut microbiota contains trillions of microorganisms of thousands of different species. Only one third of gut microbiota are common to most people; the rest are specific and contribute to enhancing genetic variation. Gut microorganisms significantly affect host nutrition, metabolic function, immune system, and redox levels, and may be modulated by several environmental conditions, including physical activity and exercise. Microbiota also act like an endocrine organ and is sensitive to the homeostatic and physiological changes associated with training; in turn, exercise has been demonstrated to increase microbiota diversity, consequently improving the metabolic profile and immunological responses. On the other side, adaptation to exercise might be influenced by the individual gut microbiota that regulates the energetic balance and participates to the control of inflammatory, redox, and hydration status. Intense endurance exercise causes physiological and biochemical demands, and requires adequate measures to counteract oxidative stress, intestinal permeability, electrolyte imbalance, glycogen depletion, frequent upper respiratory tract infections, systemic inflammation and immune responses. Microbiota could be an important tool to improve overall general health, performance, and energy availability while controlling inflammation and redox levels in endurance athletes. The relationship among gut microbiota, general health, training adaptation and performance, along with a focus on sport supplements which are known to exert some influence on the microbiota, will be discussed.

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Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study

Abstract: We show that both gut microbiota and resulting functional bacterial profiles from patients with long-standing Type 1 diabetes in good glycaemic control and high physical fitness levels are comparable with those of matched people without diabetes.

Cited by 53 publications

References 22 publications

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Intestinal Dysbiosis Secondary to Proton-Pump Inhibitor Use

Mutual Interactions among Exercise, Sport Supplements and Microbiota

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