Rare onset symptoms in multiple sclerosis

Evlice, Ahmet; Demır, Turgay; Kaleağası, Cansel; Özcan, Figen; Demirkıran, Meltem

doi:10.1080/17843286.2016.1147675

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…Finally, we found a correlation between an older age of initial evaluation by a DD specialist and the latency between the onset of DD and MD, suggesting that a shorter latency between DD and MD was associated with an earlier assessment by a DD specialist. We suspect that the presence of MD could cause patients to seek neurological evaluation earlier, while atypical onset of MS with a MD has been associated with a delay in the final diagnosis in other studies 17,18…”

Section: Discussionmentioning

confidence: 91%

“…We suspect that the presence of MD could cause patients to seek neurological evaluation earlier, while atypical onset of MS with a MD has been associated with a delay in the final diagnosis in other studies. 17,18 Our study has the limitations inherent to retrospective designs with occasional incomplete data. In addition, the response to medications was not assessed using validated objective MDs scales pretreatment and post-treatment, patients were not randomized, and patient and clinicians were not blinded to the treatment.…”

Section: Discussionmentioning

confidence: 99%

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Movement Disorders in Multiple Sclerosis and Other Demyelinating Diseases

Suarez-Cedeno

Mehanna

2021

The Neurologist

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Background: Movement disorders (MDs) have been described in demyelinating diseases (DDs). However, data is lacking in the effective treatment of these MD as well as in a potential correlation between DD lesions localization and the phenomenology of the MD and its response to treatment. Methods: Retrospective review of 185 patients with MD and DD seen at our center over a period of 7 years. Clinical imaging, medications, and therapeutic responses to both MD and DD treatments were reviewed. Results: Of the 185 patients, 62 were excluded because of a diagnosis of spasticity without any other MD. One hundred twenty three patients with DD (75% female, age 48.8±12.8 y) had one or more MD. The most common MD was ataxia followed by isolated tremor. Forty-two patients (34%) received any treatment for MD, 29 (69%) of which responded at least partially to a first MD agent and 78.6% responded at least partially to a second or third agent. Responders to the first MD therapy were more likely to have a lesion in the basal ganglia or the cerebellum, and less likely to have a lesion in the brainstem or the spinal cord, but these results could be biased by a lower-than-expected frequency of tonic spasms in our series. No correlation between DD lesions localization and the phenomenology of the MD was discovered. Conclusions: MD are common in DD and are frequently overlooked or undertreated. MD in this sample have a 69% therapeutic response to a first trial. Greater awareness of potential therapeutic options is needed to decrease disability.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Movement Disorders in Multiple Sclerosis and Other Demyelinating Diseases

Suarez-Cedeno

Mehanna

2021

The Neurologist

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“…The wide variety of visual complaints in multiple sclerosis can lead to clinical confusion [14,15]. Recent literature highlights the unusual semiology of this autoimmune demyelinating disorder (pain syndromes, movement disorders, rare cranial nerve involvement, cognitive or psychiatric symptoms [16,17]. In this case, both a late onset and an atypical clinical pattern were misleading.…”

Section: Discussionmentioning

confidence: 95%

Multiple Sclerosis Presenting as Posterior Cortical Atrophy

Ehrlé¹,

Nia²,

Jean³

et al. 2017

Dual Diagn Open Acc

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“…Rare cases of MS have been reported in the literature. 24 Among the cases we followed, neuropathic pain occurred as the first symptom in a total of 3 cases. In female patients, L-hermitte and neuralgia in the trigeminal region were described, while in male patients, neuropathic pain in the left hemibody was reported.…”

Section: Discussionmentioning

confidence: 99%

The initial symptoms in multiple sclerosis: clinical and demographic data of Çorum province

ELİAÇIK,

AYKAÇ

2023

Anatolian Current Medical Journal

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Aims: Multiple sclerosis, which has individual and societal effects such as being observed in young and middle-aged people and its long and expensive treatment process, has become an important public health issue. Methods: Between January 2022 and January 2023, 103 patients with MS were evaluated using anamnesis, neurological examinations, and neuroimaging results. The patients’ initial findings upon their MS diagnosis, the duration of diagnosis, their neurological observations in the past month, and their clinical categorization were examined. Results: Out of the 103 patients, 70 (67.96%) were female, and 33 (32.04%) were male, which was detected as a female-to-male ratio of 2.12/1. The average age of the patients was 34.41±8.4 years, and the average disease duration was 8±5.8 years. The initial findings in females were as follows; 25 patients (35.7%) had sensory, 13 patients (18.6%) had motor (pyramidal), 17 patients (24.3%) had brain stem-cerebellar, 10 patients (14.3%) had a visual impairment, and 5 patients (7.1%) had other findings. The distributions of the initial symptoms in males were as follows; 12 patients (36.4%) were motor (pyramidal), 10 patients (30.3%) were sensory, 5 patients (15.1%) were brain stem-cerebellar, 5 patients (15.1%) had visual impairment, and 1 patient (.3.1%) had other findings. The mean Expanded Disability Status Scale (EDSS) at the time of initial diagnosis was 2.5± 1.5. Among the 60 patients with RRMS who were first diagnosed, the duration elapsed between initial symptom onset and diagnosis was 12.8± 5.7 months. Conclusion: Demographic information of the MS patients followed up in our clinic, their initial complaints, frequency of clinical subtypes, differences between clinical subtypes, their clinical status in the last month, and their EDDS at their initial diagnosis and last follow-up are presented. As this represents the first data on the epidemiology of MS in our city, we believe it will contribute to the national data of Turkey and help raise MS awareness among clinicians.

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Rare onset symptoms in multiple sclerosis

Cited by 10 publications

References 24 publications

Movement Disorders in Multiple Sclerosis and Other Demyelinating Diseases

Movement Disorders in Multiple Sclerosis and Other Demyelinating Diseases

Multiple Sclerosis Presenting as Posterior Cortical Atrophy

The initial symptoms in multiple sclerosis: clinical and demographic data of Çorum province

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