Selenoproteins: Antioxidant selenoenzymes and beyond

Steinbrenner, Holger; Speckmann, Bodo; Klotz, Lars‐Oliver

doi:10.1016/j.abb.2015.06.024

Cited by 243 publications

(139 citation statements)

References 113 publications

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“…The most interesting protein in this group was selenoprotein P (SEPP1) which has anti‐oxidant activity. Secreted SEPP1 is suggested to bind to proteoglycans on the vascular endothelial surface and thereby protects against oxidative damage . However, several studies reported a detrimental effect of SEPP1 on insulin sensitivity .…”

Section: Discussionmentioning

confidence: 99%

“…Secreted SEPP1 is suggested to bind to proteoglycans on the vascular endothelial surface and thereby protects against oxidative damage . However, several studies reported a detrimental effect of SEPP1 on insulin sensitivity . Nevertheless, this finding might be explained by a dysregulated carbohydrate metabolism in T2D because SEPP1 is regulated by insulin and glucose levels .…”

Section: Discussionmentioning

confidence: 99%

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Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Niersmann

Hauck

Kannenberg

et al. 2018

Diabetes Metabolism Res

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In differentiated human adipocytes, the release of the anti-inflammatory TNFAIP6 might be part of a counterregulatory response to the pro-inflammatory action of omentin. Omentin-regulated proteins were overrepresented in pathways indicating cellular stress, a pro-inflammatory environment and a crosstalk with other organs. Other potential activators of omentin-regulated proteins point towards a central role of NFκB activation in the omentin-induced secretory process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Niersmann

Hauck

Kannenberg

et al. 2018

Diabetes Metabolism Res

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“…In humans, according to proteomics, Sec is incorporated into at least 25 different proteins [21,22,23]. The identified proteins, including glutathione peroxidases and certain forms of thioredoxin reductase, incorporate Sec into their active sites, whereas SeM is randomly incorporated into proteins [21,22,24,25,26]. As selenium compounds are generally more reactive than the corresponding sulfur derivatives ( vide infra ), one might argue that all biologically relevant selenium compounds are “Reactive Selenium Species”.…”

Section: Overview Of Chalcogens In Biologymentioning

confidence: 99%

“…Many biological functions are performed by selenoproteins, all of which contain Sec residues in their primary structures [58]. The roles of Sec in proteins has been thoroughly reviewed [21,23,24,59,60]. …”

Section: Selenium In Biologymentioning

confidence: 99%

Biological Chemistry of Hydrogen Selenide

Cupp‐Sutton

Ashby

2016

Antioxidants

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There are no two main-group elements that exhibit more similar physical and chemical properties than sulfur and selenium. Nonetheless, Nature has deemed both essential for life and has found a way to exploit the subtle unique properties of selenium to include it in biochemistry despite its congener sulfur being 10,000 times more abundant. Selenium is more easily oxidized and it is kinetically more labile, so all selenium compounds could be considered to be “Reactive Selenium Compounds” relative to their sulfur analogues. What is furthermore remarkable is that one of the most reactive forms of selenium, hydrogen selenide (HSe− at physiologic pH), is proposed to be the starting point for the biosynthesis of selenium-containing molecules. This review contrasts the chemical properties of sulfur and selenium and critically assesses the role of hydrogen selenide in biological chemistry.

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“…Selenium is an essential component of glutathione peroxidase enzyme that plays a role in the detoxification of free oxygen radicals and other toxic oxygen derivatives. Functional defect in glutathione peroxidase can cause damage to cell membranes (Steinbrenner, Speckmann, & Klotz, 2016;Oztürk et al, 2015;Sedighi, Makhlough, Shokrzadeh, & Hoorshad, 2014;Rayman, 2000). Selenium induces a decrease in serum levels of glucose in the rats treated with this element.…”

Section: Introductionmentioning

confidence: 99%

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Heidari

Sepehri

Doostdar

2016

GJHS

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In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P<0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.

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Selenoproteins: Antioxidant selenoenzymes and beyond

Cited by 243 publications

References 113 publications

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Biological Chemistry of Hydrogen Selenide

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

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