Estimated carotid–femoral pulse wave velocity has similar predictive value as measured carotid–femoral pulse wave velocity

Greve, Sara Vikström; Blicher, Marie K; Kruger, Ruan; Sehestedt, Thomas; Gram-Kampmann, Eva-Marie; Rasmussen, Susanne; Vishram, Julie K K; Boutouyrie, Pierre; Laurent, Stéphane; Olsen, Michael Hecht

doi:10.1097/hjh.0000000000000935

Cited by 134 publications

(203 citation statements)

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(21 reference statements)

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“…ePWV is calculated using only age and MAP, and therefore, might be a possible alternative to cfPWV [7]. The equation from the Reference Values for Arterial Stiffness Collaboration generated comparable levels of ePWV and cfPWV, but with large individual variations.…”

Section: Discussionmentioning

confidence: 99%

“…ePWV predicted the composite CV endpoint (CEP), CV death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease independently of the European SCORE risk (Systematic COronary Risk Evaluation), the Framingham Risk Score (FRS) as well as cfPWV, and added significantly to the Cox regression models in apparently healthy subjects [7]. Overall, in apparently healthy subjects, the hazard ratios for ePWV were not significantly different from those for cfPWV, and when included in the same model, both ePWV and cfPWV significantly predicted CEP.…”

Section: Discussionmentioning

confidence: 99%

“…Overall, in apparently healthy subjects, the hazard ratios for ePWV were not significantly different from those for cfPWV, and when included in the same model, both ePWV and cfPWV significantly predicted CEP. However, among patients, defined as persons with a history of CVD or diabetes and persons in treatment with antihypertensive drugs, cholesterol-reducing drugs or antidiabetic drugs, ePWV in contrast to the measured cfPWV did not have additive predictive value [7]. This suggests that ePWV and cfPWV do not catch the same risk information.…”

Section: Discussionmentioning

confidence: 99%

“…However, NRI was not significant when FRS was used instead of SCORE. The higher NRI using SCORE may reflect that SCORE was constructed to predict CV death and not CEP [7]. When investigating indication for primary CV prevention, only the apparently healthy subjects are of interest.…”

Section: Discussionmentioning

confidence: 99%

“…In the recently published paper by Greve et al [7], our group has demonstrated that an estimated cfPWV (ePWV) can be calculated from age and MAP using the equation from the Reference Values for Arterial Stiffness Collaborations' publication in a general Danish population of 2,366 subjects and its replication in 1,045 hypertensives from a Paris cohort. …”

Section: Introductionmentioning

confidence: 99%

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Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure

Greve¹,

Laurent

Olsen

2016

Pulse

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In a recently published paper, Greve et al [J Hypertens 2016;34:1279-1289] investigate whether the estimated carotid-femoral pulse wave velocity (ePWV), calculated using an equation derived from the relationship between carotid-femoral pulse wave velocity (cfPWV), age, and blood pressure, predicts cardiovascular disease (CVD) as good as the measured cfPWV. Because ePWV predicts CVD as good as cfPWV, some might wonder whether ePWV could be replaced by cfPWV, which is a time-consuming measurement requiring an expensive apparatus. This question is addressed in this mini-review.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure

Greve¹,

Laurent

Olsen

2016

Pulse

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Association of Estimated Pulse Wave Velocity With Survival

et al. 2019

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Key PointsQuestionDo estimated markers of aortic stiffness, such as estimated pulse wave velocity and their change with time, predict cardiovascular events in individuals with hypertension?FindingsThe results of this post hoc analysis of the randomized Systolic Blood Pressure Intervention Trial (SPRINT) support an incremental predictive role of estimated pulse wave velocity with outcomes beyond Framingham Risk Score. Individuals whose estimated pulse wave velocity responded to 1 year of antihypertensive treatment demonstrated a 42% lower risk of death compared with nonresponders independent of systolic blood pressure reduction in the standard treatment group of the Systolic Blood Pressure Intervention Trial.MeaningAortic stiffness could be used in individuals with hypertension to assess risk; it could be used also as a therapeutic target to assist patient management and improve prognosis.

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Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study

Aimagambetova,

Ariko,

Gardener

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONArterial stiffness is linked to age‐related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population.METHODSWe included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI‐cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non‐Hispanic Black, 15% non‐Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5.0 ± 0.6 years later. ePWV was calculated using baseline age and blood pressure. Cognition and cognitive change scores were regressed on ePWV in multivariable linear regression models.RESULTSIn adjusted models, ePWV (mean 11 ± 2 m/s) was significantly associated with cognition (b = −0.100, 95% CI, −0.120, −0.080) and cognitive change over time (b = −0.063, 95% CI, −0.082, −0.045). Effect modification by race and sex was found.DISCUSSIONIn this multiethnic population, the associations of ePWV with cognitive performance underline the role of vascular stiffness in age‐related cognitive decline.Highlights ePWV is a modest but independent predictor of cognitive function and cognitive decline among older individuals. After adjustment, the ePWV measure was inversely associated with performance and decline in global cognition, processing speed, episodic memory, executive function, and semantic memory. After adjustment, modification of the association between ePWV and change in episodic memory and executive function by race and ethnicity was suggested by a significant interaction term. The association between ePWV and episodic memory decline was stronger in females.

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Estimated carotid–femoral pulse wave velocity has similar predictive value as measured carotid–femoral pulse wave velocity

Abstract: ePWV predicted major cardiovascular events independently of SCORE, FRS and cfPWV indicating that these traditional risk scores have underestimated the complicated impact of age and blood pressure on arterial stiffness and cardiovascular risk.

Cited by 134 publications

References 20 publications

Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure

Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure

Association of Estimated Pulse Wave Velocity With Survival

Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study

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