Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Šćepanović, Milena; Jovanović, Olivera; Keber, Dusan; Jovanović, Ivan; Miljuš, Dragan; Nikolić, Goran; Kovačević, Bojan; Pavlović, Aleksandra; Dugalić, Predrag; Nagorni, Aleksandar; Grgov, Saša; Knežević, S; Milenkovic, Predrag; Perišić, Nenad; Faivre, Jean

doi:10.1097/cej.0000000000000247

Cited by 11 publications

(12 citation statements)

References 24 publications

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“…These were the main reasons for establishing a 14-day follow-up and a routine postoperative physical examination that was conducted after 2 weeks by surgeons [13]. Unlike developed countries, our patients were diagnosed with a higher stage of disease during the nonexistence of organized national screening at the time of this research, with an insolvent health care system and low health care consumption per capita [14, 15]. …”

Section: Discussionmentioning

confidence: 99%

Preoperative Midregional Pro-Adrenomedullin and High-Sensitivity Troponin T Predict Perioperative Cardiovascular Events in Noncardiac Surgery

et al. 2018

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Objective: We evaluated the utility of preoperative midregional (MR) pro-adrenomedullin (proADM) and cardiac troponin T (TnT) for improved detection of patients at high risk for perioperative cardiac events and mortality after major noncardiac surgery. Subjects and Methods: This prospective, single-center, observational study enrolled 79 patients undergoing major noncardiac surgery. After initial clinical assessment (clinical history, physical examination, echocardiogram, blood tests, and chest X-ray), MR-proADM and high-sensitivity TnT (hsTnT) were measured within 48 h prior to surgery by immunoluminometric and electrochemiluminescence immunoassay. Patients were followed by the consulting physician until discharge or up to 14 days in the hospital after surgery. Perioperative cardiac events included myocardial infarction and development or aggravation of congestive heart failure. Data were compared between patients who developed target events and event-free patients. Results: Within 14 days of monitoring, 14 patients (17.72%) developed target events: 9 (11.39%) died and 5 (6.33%) developed cardiovascular events. The average age of the patients was 71.29 ± 6.62 years (range: 55–87). Sex, age, and hsTnT did not significantly differ between groups. MR- proADM concentration was higher in deceased patients (p = 0.01). The upper quartile of MR-proADM was associated with a fatal outcome (66.7 vs. 20.0%, p < 0.01) and with cardiovascular events (64.3 vs. 16.9%, p < 0.01). MR-proADM above the cutoff value (≥0.85) was associated with a fatal outcome (88.9 vs. 20.0%, p < 0.01) and cardiovascular events (71.4 vs. 28.6%, p < 0.01); this association was not observed for hsTnT. Conclusion: Preoperative measurement of MR-proADM provides useful information for perioperative cardiac events in high-risk patients scheduled for noncardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Preoperative Midregional Pro-Adrenomedullin and High-Sensitivity Troponin T Predict Perioperative Cardiovascular Events in Noncardiac Surgery

et al. 2018

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“…Some studies specified only who delivered the intervention and it was unclear who recruited participants. Opportunistic interventions (5/6) that were conducted from clinics or hospitals achieved an uptake of > 65% [19,21,[25][26][27]. Most population-based sampling studies achieved better stool test uptake proportions when participants were approached face-to-face (40,53,63,76, 83 and 98%) compared to recruitment through letter, phone, or media call (14, 35 and 63%).…”

Section: Recruitmentmentioning

confidence: 99%

“…Many studies described the first time when an existing intervention was piloted in a country. Four studies based in China, Bulgaria and Serbia [27,29,38,40,42,43] reported interventions that followed (revised) screening guidelines/recommendations and 3/4 studies reported an uptake > 65% and one reported an uptake between 45 and 65%. Studies also reported that interventions were guided by experts [24,27,36].…”

Section: Implementation Considerationsmentioning

confidence: 99%

“…Four studies based in China, Bulgaria and Serbia [27,29,38,40,42,43] reported interventions that followed (revised) screening guidelines/recommendations and 3/4 studies reported an uptake > 65% and one reported an uptake between 45 and 65%. Studies also reported that interventions were guided by experts [24,27,36]. Interventions that were guided by a theory were described earlier.…”

Section: Implementation Considerationsmentioning

confidence: 99%

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The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review

et al. 2021

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Background Low- and middle-income countries (LMICs) experienced increasing rates of colorectal cancer (CRC) incidence in the last decade and lower 5-year survival rates compared to high-income countries (HICs) where the implementation of screening and treatment services have advanced. This review scoped and mapped the literature regarding the content, implementation and uptake of CRC screening interventions as well as opportunities and challenges for the implementation of CRC screening interventions in LMICs. Methods We systematically followed a five-step scoping review framework to identify and review relevant literature about CRC screening in LMICs, written in the English language before February 2020. We searched Medline, Embase, Web of Science and Google Scholar for studies targeting the general, asymptomatic, at-risk adult population. The TIDieR tool and an implementation checklist were used to extract data from empirical studies; and we extracted data-informed insights from policy reviews and commentaries. Results CRC screening interventions (n = 24 studies) were implemented in nine middle-income countries. Population-based screening programmes (n = 11) as well as small-scale screening interventions (n = 13) utilised various recruitment strategies. Interventions that recruited participants face-to-face (alone or in combination with other recruitment strategies) (10/15), opportunistic clinic-based screening interventions (5/6) and educational interventions combined with screening (3/4), seemed to be the strategies that consistently achieved an uptake of > 65% in LMICs. FOBT/FIT and colonoscopy uptake ranged between 14 and 100%. The most commonly reported implementation indicator was ‘uptake/reach’. There was an absence of detail regarding implementation indicators and there is a need to improve reporting practice in order to disseminate learning about how to implement programmes. Conclusion Opportunities and challenges for the implementation of CRC screening programmes were related to the reporting of CRC cases and screening, cost-effective screening methods, knowledge about CRC and screening, staff resources and training, infrastructure of the health care system, financial resources, public health campaigns, policy commitment from governments, patient navigation, planning of screening programmes and quality assurance.

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“…The participation rate was quite satisfactory (67.8%). Among individuals with a positive test, 69.7% agreed to undergo colonoscopy 3.…”

Section: Participation Rates Of Colorectal Cancer Screening Programsmentioning

confidence: 99%

Screening for colorectal cancer: the role of the primary care physician

Triantafillidis

Vagianos

Gikas³

et al. 2017

European Journal of Gastroenterology &Amp; Hepatology

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In recent years, the role of primary care physicians (PCPs) in the diagnosis and management of gastrointestinal disorders, including screening for colorectal cancer (CRC), has been recognized as very important. The available data indicate that PCPs are not adequately following CRC screening guidelines because a number of factors have been identified as significant barriers to the proper application of CRC screening guidelines. These factors include lack of time, patient reluctance, and challenges related to scheduling colonoscopy. Further positive engagement of PCPs with CRC screening is required to overcome these barriers and reach acceptable levels in screening rates. To meet the expectations of modern medicine, PCPs should not only be able to recommend occult blood testing or colonoscopy but also, under certain conditions, able to perform colonoscopy. In this review, the authors aim to provide the current knowledge of the role of PCPs in increasing the rate and successfully implementing a screening program for CRC by applying the relevant international guidelines.

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Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Cited by 11 publications

References 24 publications

Preoperative Midregional Pro-Adrenomedullin and High-Sensitivity Troponin T Predict Perioperative Cardiovascular Events in Noncardiac Surgery

Preoperative Midregional Pro-Adrenomedullin and High-Sensitivity Troponin T Predict Perioperative Cardiovascular Events in Noncardiac Surgery

The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review

Screening for colorectal cancer: the role of the primary care physician

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