Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort

Dias, Joana Alves; Hellstrand, Sophie; Ericson, Ulrika; Gullberg, Bo; Nilsson, Jan; Alm, Ragnar; Persson, Margaretha; Engström, Gunnar; Fredrikson, Gunilla Nordin; Hedblad, Bo; Wirfält, Elisabet

doi:10.3109/1354750x.2016.1160431

Cited by 3 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no published data on how the plasma level of IL-5 varies over time in the same individual. A study where blood samples were repeatedly drawn from healthy volunteers during a 2-month period found correlations coefficients ranging from 0.6 to 0.9 for IL-1β, IL-6, and IL-8 suggesting that plasma cytokine levels in healthy individuals are relatively stable (31). Furthermore, it cannot be excluded that the long storage period affected the possibility to correctly analyze plasma IL-5.…”

Section: Discussionmentioning

confidence: 99%

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Knutsson

Björkbacka

Dunér

et al. 2019

JACC: Basic to Translational Science

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Knutsson

Björkbacka

Dunér

et al. 2019

JACC: Basic to Translational Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…One single measurement of these biomarkers was previously found to be highly reliable within a period of few months, in sub-samples drawn from the MDC cohort [ 63 ]. However, some of these biomarkers have limitations during longer time periods [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort

et al. 2016

Self Cite

View full text Add to dashboard Cite

ObjectiveAlthough cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association.MethodsIn the Malmö Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55–73 years at baseline (1991–96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31st, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression.ResultsInverse associations with breast cancer were seen in fully-adjusted models, for 2nd and 3rd tertiles of ox-LDL, OR (95% CI): 0.65 (0.47–0.90), 0.63 (0.45–0.89) respectively, p-trend = 0.01; and for the 3rd tertile of TNF-α, 0.65 (0.43–0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05–2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer.ConclusionOur study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.

show abstract

“…Nonfasting blood samples of the participants were drawn at each hospital when the participants were interviewed between 2015 and 2019. High correlations between nonfasting and fasting levels of inflammatory markers were reported, 22,23 and several cohort studies used nonfasting samples for the association with chronic disease 24,25 . The plasma samples were shipped to the centralized laboratory (Seegene, Seoul, Korea) and hs‐CRP levels were measured with a particle‐enhanced immunoturbidimetric assay using Cobas 8000 C702 (Roche, Germany).…”

Section: Methodsmentioning

confidence: 99%

Associations of body mass index and weight change with circulating levels of high‐sensitivity C‐reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors

Cho

Song

Kim

et al. 2022

Asia-Pac J Clncl Oncology

View full text Add to dashboard Cite

Aim This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea. Methods A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. The plasma levels of inflammatory markers were measured, including high‐sensitivity C‐reactive protein, interleukin (IL)‐6, IL‐8, tumor necrosis factor‐α, and adiponectin. A summary z‐score was calculated by summing up the z‐scores of each biomarker. The least‐square means and 95% confidence intervals (CIs) were calculated using a generalized linear model and odds ratios (ORs) and 95% CIs for the elevated levels of inflammatory markers with a multivariate logistic regression model. Results Participants with a BMI ≥27.5 kg/m2 at the study enrollment and at diagnosis were significantly associated with elevated summary z‐scores compared to those with a BMI < 23 kg/m2; the ORs (95% CIs) were 5.42 (2.15–13.71) for current BMI and 3.66 (1.68–7.98) for BMI at diagnosis, respectively. Additionally, a weight loss > 5% since diagnosis was associated with a lower prevalence of high summary z‐scores; the OR (95% CI) was .20 (.08–.52) compared to a stable weight. Conclusions A high BMI at diagnosis and current BMI with a greater degree were associated with unfavorable levels of inflammatory markers among breast cancer survivors. Additionally, weight loss since diagnosis was inversely associated with these markers.

show abstract

Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort

Abstract: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.

Cited by 3 publications

References 30 publications

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort

Associations of body mass index and weight change with circulating levels of high‐sensitivity C‐reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors

Contact Info

Product

Resources

About