Antibacterial Constituents of Hainan <i>Morinda citrifolia</i> (Noni) Leaves

Zhang, Weimin; Wang, Wei; Zhang, Jingjing; Wang, Zhirong; Wang, Yu; Hao, Wang-Jun; Huang, Wuyang

doi:10.1111/1750-3841.13302

Cited by 42 publications

(29 citation statements)

References 23 publications

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“…Anthraquinone class compounds can also be found in poorly exploited M. citrifolia structures. Wang et al (2016) isolated two new anthraquinones previously unknown from the bark of the M. citrifolia stem: 1,3-dihydroxy-5-methoxy-6-methoxymethyl-2methyl-9,10-anthraquinone and 1,3-dihydroxy-5-methoxy-2,6bismethoxymethyl-9,10-anthraquinone. In addition to those already mentioned, another 10 known derivatives of anthraquinones were identified, among them damnacantal and three more coumarin derivatives, including scopoletin.…”

Section: Biochemical Characteristicsmentioning

confidence: 99%

“…Recently, Wang et al (2016) extracted two new anthraquinones from the barks of the M. citrifolia stem: 1,3-dihydroxy-5-methoxy-6-methoxymethyl-2-methyl-9,10-anthraquinone (1) 3-dihydroxy-5-methoxy-2,6-bismethoxymethyl-9,10-anthraquinone (2). Nuclear magnetic resonance spectroscopy assay (NMR spectroscopy) revealed that both compounds have a very similar molecular skeleton.…”

Section: Antiviral Activitymentioning

confidence: 99%

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Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

106

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Morinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.

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Section: Biochemical Characteristicsmentioning

confidence: 99%

Section: Antiviral Activitymentioning

confidence: 99%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

106

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“…Growing evidence suggests that noni has important antimicrobial and antibacterial activities. Extracts of noni leaves made with three different solvents, ethyl acetate extract, n -butanol, or water, showed a very strong antimicrobial and antibacterial activity against some microorganisms, including Proteus vulgaris , Staphylococcus aureus , Bacillus subtilis , and Escherichia coli [17]. …”

Section: Morinda Citrifolia Linn (Noni)mentioning

confidence: 99%

“…It has been investigated as an alternative in anticancer, antibacterial, and antimicrobial therapies, and in the treatment of esophageal reflux and ulcers in animals [17,18,19,20,21]. In humans, there are few studies showing the beneficial effects of noni.…”

Section: Introductionmentioning

confidence: 99%

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

et al. 2017

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Cultural and economic shifts in the early 19th century led to the rapid development of companies that made good profits from technologically-produced commodities. In this way, some habits changed in society, such as the overconsumption of processed and micronutrient-poor foods and devices that gave rise to a sedentary lifestyle. These factors influenced host-microbiome interactions which, in turn, mediated the etiopathogenesis of “new-era” disorders and diseases, which are closely related, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, and inflammatory bowel disease, which are characterized by chronic dysregulation of metabolic and immune processes. These pathological conditions require novel and effective therapeutic approaches. Morinda citrifolia (noni) is well known as a traditional healing plant due to its medicinal properties. Thus, many studies have been conducted to understand its bioactive compounds and their mechanisms of action. However, in obesity and obesity-related metabolic (dysfunction) syndrome, other studies are necessary to better elucidate noni’s mechanisms of action, mainly due to the complexity of the pathophysiology of obesity and its metabolic dysfunction. In this review, we summarize not only the clinical effects, but also important cell signaling pathways in in vivo and in vitro assays of potent bioactive compounds present in the noni plant which have been reported in studies of obesity and obesity-associated metabolic dysfunction.

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“…Based on the polarity order of organic solvents, petroleum ether, ethyl acetate, chloroform and n butanol were added in succession to extract the crude extract of E. dulcis peel [28,29]. Each extraction was repeated three times to obtain four organic solvent extracts.…”

Section: Extraction and Separation Of Compounds Present In E Dulcis mentioning

confidence: 99%

Allelochemicals Extracted from Eleocharis dulcis and their Inhibitory Effects on Microcystis aeruginosa

Wen¹,

Shu²,

Chen³

et al. 2017

J Chem Eng Process Technol

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Allelochemicals are considered to be effective substances for controlling the outbreak of harmful cyanobacteria. In this study, Eleocharis dulcis peel fractions with an inhibitory effect on Microcystis aeruginosa were isolated by extraction and purification. The extracted organic compounds were identified by gas chromatography-mass spectrometry (GC-MS), and the allelopathic effect and mechanism underlying the inhibition of M. aeruginosa were explored. The results demonstrated that the exogenous compound, eriodictyol, corresponding to one of the detected flavonoids (C H 12 O 6) could inhibit the growth of M. aeruginosa, indicating that the flavonoid C 15 H 12 O 6 is one of the allelochemicals contained in E. dulcis. Levels of chlorophyll a (Chl-a), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and reduced glutathione (GSH) of cell health in M. aeruginosa were analysed. Our results show that the damage to the antioxidant enzymes of algal cells caused by eriodictyol could be a main contributing factor to the decrease in the number of algal cells and even cell death.

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Antibacterial Constituents of Hainan Morinda citrifolia (Noni) Leaves

Cited by 42 publications

References 23 publications

Properties and Applications of Morinda citrifolia (Noni): A Review

Properties and Applications of Morinda citrifolia (Noni): A Review

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

Allelochemicals Extracted from Eleocharis dulcis and their Inhibitory Effects on Microcystis aeruginosa

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