A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release

Chuang, Er-Tuan; Lin, Chia Chen; Chen, Ko Jie; Wan, De Hui; Lin, Kun; Ho, Yi Cheng; Lin, Po‐Yen; Sung, Hsing‐Wen

doi:10.1016/j.biomaterials.2016.03.040

Cited by 61 publications

(33 citation statements)

References 38 publications

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“…The programmability of light-responsive nanomaterials can be enhanced by attaching additional functional groups such as folic acid [73], antibodies [34], aptamer [98], PEG [73], and thermoresponsive materials [85,98] for targeted and efficient drug delivery. Xiao et al (2012) [85] developed interesting light-responsive nanocarriers based on complementary DNA strands, which contained sequential CG base pairs to provide a loading platform for doxorubicin (Figure 3).…”

Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

“…To further enhance drug delivery at the targeted site, ammonium bicarbonate-loaded bubble-generating and mucin-1 aptamer surface-modified thermoresponsive liposomes were used together with gold nanocages [98]. Upon irradiation, the gold nanocages converted the NIR into localized heat and decomposed the loaded ammonium bicarbonate to generate CO 2 bubbles, which created permeable defects on the lipid membrane and rapidly triggered doxorubicin release (Figure 4).…”

Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

“…Upon NIR exposure, the AuNGs convert the NIR to heat, which heats the ABC and generates bubble that disrupts the liposome to releases the Dox at the target site (Figure taken from reference [98]).…”

Section: Figurementioning

confidence: 99%

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Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.

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Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

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Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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“…The most recent study of MUC1‐targeted PTT was performed by Chuang E‐Y and co‐workers, who attached an Fluorescein isothiocyanate FITC‐labeled MUC1 aptamer and a Cy3 fluorophore short DNA (Sh‐DNA) onto the surface of a nanoliposome (Lip). The attachment of this MUC1–APT to MUC1 protein on the surface of MUC1+ tumor cells led to the dissociation of the Cy3‐ShDNA and a consequent increased fluorescence intensity of the FITC.…”

Section: The Muc1 Aptamer In Targeted Drug Deliverymentioning

confidence: 99%

Anti‐MUC1 aptamer: A potential opportunity for cancer treatment

Nabavinia

Gholoobi

Charbgoo

et al. 2017

Medicinal Research Reviews

111

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“…The authors showed that the aptamer-targeted liposome- TPEN complexes specifically targeted prostate cancer cell both in vitro and in vivo [99]. Of note, a recent paper reported a multifunctional liposomal system for the simultaneous delivery of DOX, heat, and a bubble-generating agent (ammonium bicarbonate, ABC) [100]. The anti-MUC-1 aptamer was conjugated on the surface of liposomes encapsulated with gold nanocages, ABC and DOX.…”

Section: Aptamer-nanoparticles Systemsmentioning

confidence: 99%

Aptamer-Mediated Targeted Delivery of Therapeutics: An Update

2016

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The selective delivery of drugs in a cell- or tissue-specific manner represents the main challenge for medical research; in order to reduce the occurrence of unwanted off-target effects. In this regard, nucleic acid aptamers have emerged as an attractive class of carrier molecules due to their ability to bind with high affinity to specific ligands; their high chemical flexibility; as well as tissue penetration capability. To date, different aptamer-drug systems and aptamer–nanoparticles systems, in which nanoparticles function together with aptamers for the targeted delivery, have been successfully developed for a wide range of therapeutics, including toxins; peptides; chemotherapeutics and oligonucleotides. Therefore, aptamer-mediated drug delivery represents a powerful tool for the safe and effective treatment of different human pathologies, including cancer; neurological diseases; immunological diseases and so on. In this review, we will summarize recent progress in the field of aptamer-mediated drug delivery and we will discuss the advantages, the achieved objectives and the challenges to be still addressed in the near future, in order to improve the effectiveness of therapies.

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A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release

Cited by 61 publications

References 38 publications

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Anti‐MUC1 aptamer: A potential opportunity for cancer treatment

Aptamer-Mediated Targeted Delivery of Therapeutics: An Update

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