Increased iron stores prolong the <scp>QT</scp> interval – a general population study including 20 261 individuals and meta‐analysis of thalassaemia major

Henriksen, Leif; Petri, Anne-Sofie; Hasselbalch, Hans Carl; Kanters, Jørgen K.; Ellervik, Christina

doi:10.1111/bjh.14099

Cited by 7 publications

(9 citation statements)

References 48 publications

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“…QTc interval is reasonably specific to diagnose iron overload cardiomyopathy. Previous studies revealed that increasing iron stores in men correlated with prolonged QTc interval and may induce cardiac arrhythmias, including torsades de pointes, ventricular fibrillation, and sudden cardiac death [25,26]. We found no significant differences in QT and QTc intervals between ferritin groups nor between MR-T2 � groups.…”

Section: Plos Onecontrasting

confidence: 70%

Electrophysiological properties and heart rate variability of patients with thalassemia major in Jakarta, Indonesia

et al. 2023

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Beta thalassemia major (TM) is a common hereditary disease in Indonesia. Iron overload due to regular transfusion may induce myocardial iron deposition leading to electrophysiological dysfunction and functional disorders of the heart. Ventricular arrhythmia is one of the most common causes of sudden cardiac death in thalassemia patients. This cross-sectional study of 62 TM patients aged 10–32 years in Cipto Mangunkusumo General Hospital was done to assess their electrophysiological properties and heart rate variability, including 24- hour Holter monitoring, signal averaged electrocardiogram (SAECG) for detection of ventricular late potential (VLP), and determination of heart rate variability (HRV). We also assessed their 12-lead ECG parameters, such as P wave, QRS complex, QT/ QTc interval, QRS dispersion, and QT/ QTc dispersion. Iron overload was defined by T2-star magnetic resonance (MR-T2*) values of less than 20 ms or ferritin level greater than 2500 ng/mL. Subjects were grouped accordingly. There were significant differences of QTc dispersion (p = 0.026) and deceleration capacity (p = 0.007) between MR-T2* groups. Multivariate analysis showed an inverse correlation between QTc dispersion and MR-T2* values. There was a proportional correlation between heart rate deceleration capacity in the low MR-T2* group (p = 0.058) and the high ferritin group (p = 0.007). No VLPs were detectable in any patients. In conclusion, prolonged QTc dispersion and decreased heart rate deceleration capacity were significantly correlated with greater odds of iron overload among patients with Thalassemia major.

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Section: Plos Onecontrasting

confidence: 70%

Electrophysiological properties and heart rate variability of patients with thalassemia major in Jakarta, Indonesia

et al. 2023

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“…To function as the control group without diabetes mellitus, participants were included from the Danish General Suburban Population Study (GESUS), which included participants between 2010–2013 aged 20 years or older ; 8823 participants had a digital ECG on file. Cases and controls were matched by age and gender, and two controls were matched for each case.…”

Section: Participants and Methodsmentioning

confidence: 99%

Cardiac repolarization and depolarization in people with Type 1 diabetes with normal ejection fraction and without known heart disease: a case‐control study

et al. 2018

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“…Overall, 19 405 people were included in this study. Details about the GESUS study design have previously been described …”

Section: Methodsmentioning

confidence: 99%

Hidradenitis suppurativa and electrocardiographic changes: a cross‐sectional population study

Juhl

Miller

Jemec³

et al. 2017

Br J Dermatol

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SummaryBackground Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease. Objectives To investigate the hitherto unknown electrocardiographic (ECG) changes associated with HS, which have recently been associated with significant cardiovascular burden. Methods Data were obtained from the cross-sectional Danish General Population Study (GESUS). HS diagnosis was based on a validated self-reported questionnaire; 404 individuals met the HS diagnosis criteria and 19 001 controls without HS were identified. Severity of HS was staged according to a modified Hurley score. The ECG parameters of heart rate (HR), PR interval, QRS duration, JTc interval and QTc interval were obtained from 12-lead resting ECGs. We investigated the difference in means by unpaired t-test or ANOVA. Results HR was significantly higher [mean difference 2Á3 beats per min (bpm), 95% confidence interval (CI) 1Á2-3Á4; P < 0Á01] when adjusting for age and sex, but when adjusting for multivariates, there was no significant difference (0Á3 bpm, 95% CI -0Á7 to 1Á4; P = 0Á52). Severe HS was significantly associated with increased HR across all models (2Á9 bpm, 95% CI 0Á7-5Á1; P = 0Á01). Mean QRS duration was significantly shorter in the group with mild HS but not in the groups with moderate and severe HS. Conclusions Mean resting HR in patients with severe HS was significantly higher compared with controls. Given that resting HR is associated with increased risk of all-cause and cardiovascular mortality, and that patients with HS have increased risk of cardiovascular events, this finding is potentially important, easily testable and intervenable.

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Increased iron stores prolong the QT interval – a general population study including 20 261 individuals and meta‐analysis of thalassaemia major

Cited by 7 publications

References 48 publications

Electrophysiological properties and heart rate variability of patients with thalassemia major in Jakarta, Indonesia

Electrophysiological properties and heart rate variability of patients with thalassemia major in Jakarta, Indonesia

Cardiac repolarization and depolarization in people with Type 1 diabetes with normal ejection fraction and without known heart disease: a case‐control study

Hidradenitis suppurativa and electrocardiographic changes: a cross‐sectional population study

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