Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis

Xue, Ting; Yu, Lumin; Shang, Fei; Li, Wenchang; Ming, Zhang; Ni, Jingtian; Chen, Xiaolin

doi:10.3168/jds.2015-10543

Cited by 29 publications

(24 citation statements)

References 23 publications

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“…It has been reported that quorum sensing is involved in regulating drug resistance of bacteria (Liang et al, 2016 ; Xue et al, 2016 ; Yufan et al, 2016 ; Lai et al, 2017 ), but few studies have investigated the regulation of stress resistance by quorum sensing or LuxS. Quorum sensing facilitates the stress resistance of E. coli in microcapsules by detecting the expression of luxS /AI-2 system (Gao et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Liu

Zhang

et al. 2018

Front. Microbiol.

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Probiotics have evoked great interest in the past years for their beneficial effects. The aim of this study was to investigate whether luxS overexpression promotes the stress resistance of Lactobacillus paraplantarum L-ZS9. Here we show that overexpression of luxS gene increased the production of autoinducer-2 (AI-2, quorum sensing signal molecule) by L. paraplantarum L-ZS9. At the same time, overexpression of luxS promoted heat-, bile salt-resistance and biofilm formation of the strain. RNAseq results indicated that multiple genes encoding transporters, membrane proteins, and transcriptional regulator were regulated by luxS. These results reveal a new role for LuxS in promoting stress resistance and biofilm formation of probiotic starter.

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Section: Discussionmentioning

confidence: 99%

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Liu

Zhang

et al. 2018

Front. Microbiol.

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“…Among them, SAM is a methyl donor, and the intermediate product S-adenosylhomocysteine (SAH) is hydrolyzed by 5'-methylthioadenosine/S-adenosylhomocysteine ribozyme (Pfs) to S-ribosylhomocysteine (SRH) and adenine [53]. LuxS (S-ribosylhomocysteinase), the encoded product of luxS, is an AI-2 synthetase [54]. LuxS catalyzes the cleavage of SRH into DPD and homocysteine.…”

Section: Microbial Quorum Sensing System and Its Regulation Mechanismmentioning

confidence: 99%

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

2020

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Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.

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“…TEM-type ESBL includes TEM-1 and TEM-2 (41). Xue et al (42) showed that exogenous AI-2 increased the antibiotic resistance of clinical E. coli strains isolated from cow's papillitis by upregulating the expression of TEM-type enzyme in an LsrR-dependent manner. Transposons are a group of mobile genetic elements that are defined as a DNA sequence (43).…”

Section: Luxs/ai-2 Qs System Contributes To Antibiotic Resistancementioning

confidence: 99%

Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance

Wang

Liu

Grenier

et al. 2019

Antimicrob Agents Chemother

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The quorum-sensing (QS) system is an intercellular cell-cell communication mechanism that controls the expression of genes involved in a variety of cellular processes and that plays critical roles in the adaption and survival of bacteria in their environment. The LuxS/AI-2 QS system, which uses AI-2 (autoinducer-2) as a signal molecule, has been identified in both Gram-negative and Gram-positive bacteria. As one of the important global regulatory networks in bacteria, it responds to fluctuations in the numbers of bacteria and regulates the expression of a number of genes, thus affecting cell behavior. We summarize here the known relationships between the LuxS/AI-2 system and drug resistance, discuss the inhibition of LuxS/AI-2 system as an approach to prevent bacterial resistance, and present new strategies for the treatment of drug-resistant pathogens.

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Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis

Cited by 29 publications

References 23 publications

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance

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