Ear Cubes for local controlled drug delivery to the inner ear

Gehrke, M.; Sircoglou, J.; Gnansia, Dan; Tourrel, Guillaume; willart, Jean-François; Danède, Florence; Lacante, E.; Vincent, C.; Siepmann, Florence; Siepmann, Juergen

doi:10.1016/j.ijpharm.2016.04.003

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…Indeed, the release of the drug away from the release surfaces, the water or the medium, takes longer to migrate through the thickness of the polymer [2,35]. This study is applicable in all cases of drug delivery as stents, ear pads, patches, and contact lenses [6,34,[36][37][38][39][40][41]. In all these cases, some parameters have importance like the geometry of the drug holders, glass transition temperature, viscosity, drug percentage, drug type, coating thickness, and release kinetics [6,28].…”

Section: Introductionmentioning

confidence: 89%

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

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Drug-eluting implants with a polymeric matrix are currently widely used and the interest of modeling their behavior is increasing. This article aims to present preliminary results of an in vitro under steady flow, study the behavior of drug-loaded polyurethane samples used as drug delivery matrices. Polyisocyanate and polyol synthesis supplied the polyurethane studied in this work. A molding and heat at 50°C for about 30 min make it possible to prepare films from these components. The prepared samples are placed in the impermeable Plexiglas tube and they are in contact with the medium (distilled water). Tests have been performed without flow and three other cases with steady flow, at a temperature of 37°C. The substance active incorporated in these films, as the drug, for carrying out the release tests is the C 20 H 24 C 12 N 2 O 3. This drug supplied in granular form is composed of a mixture in the following proportions, 15 mg of diclofenac epolamine and 50 mg of diclofenac-sodium. Four sample variants were carefully prepared: pure-PU and PU loaded in a mass ratio of 10, 20 or 30%. Weighing, DSC, FT-IR, and DMTA are the methods used to analyze the samples. In addition, SEM micrographs are used to explore qualitatively the microstructure during the release tests. The kinetics in vitro of the drug release and water absorption by the polyurethane films are discussed in detail. The results show that these two quantities depend on the initial drug loading and the flow rate value, as a function of the in vitro incubation time.

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Section: Introductionmentioning

confidence: 89%

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

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“…The cuboid portion acts as a drug reservoir, so the drug can diffuse through the cylindrical portion into the perilymph. The cuboid has two halves that can be loaded with two different drug formulations, offering increased flexibility compared to a previously proposed monoblock system . The Hybrid Ear Cube has been shown to retain its structure and size, even when immersed for up to 100 days in artificial perilymph, and has demonstrated very slow release rates, with <0.5% of loaded dexamethasone, or 0.5 μg, released after 2 months.…”

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

“…The cuboid has two halves that can be loaded with two different drug formulations, offering increased flexibility compared to a previously proposed monoblock system. 94 F I G U R E 5 Hybrid ear cube. The hybrid ear cube is a siliconebased implant that consists of a cuboid portion placed in the middle ear adjacent to the oval window (shown) or round window and a cylindrical structure that passes through the oval window or round window that remains in contact with the perilymph.…”

Section: Advances With Direct Intracochlear Deliverymentioning

confidence: 99%

Inner ear delivery: Challenges and opportunities

Szeto

Chiang

Valentini

et al. 2019

Laryngoscope Investig Oto

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Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Data Sources The databases used were PubMed, EMBASE, and Web of Science. Results Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants. Conclusions In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation. Level of Evidence NA

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“…For gene and cell therapy, intracochlear routes are necessary, and round window, cochleostomy and canalostomy approaches have been developed in animals (Gehrke et al, 2016;György et al, 2017;Plontke et al, 2016;Suzuki et al, 2017;Yoshimura et al, 2018).…”

Section: Delivery Of Therapeutics To the Inner Earmentioning

confidence: 99%

Early phase trials of novel hearing therapeutics: Avenues and opportunities

Schilder

Mandavia

et al. 2019

Hearing Research

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Novel hearing therapeutics are rapidly progressing along the innovation pathway and into the clinical trial domain. Because these trials are new to the hearing community, they come with challenges in terms of trial design, regulation and delivery. In this paper, we address the key scientific and operational issues and outline the opportunities for interdisciplinary and international collaboration these trials offer. Vital to the future successful implementation of these therapeutics is to evaluate their potential for adoption into healthcare systems, including consideration of their health economic value. This requires early engagement with all stakeholder groups along the hearing innovation pathway.

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Ear Cubes for local controlled drug delivery to the inner ear

Cited by 24 publications

References 27 publications

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Inner ear delivery: Challenges and opportunities

Early phase trials of novel hearing therapeutics: Avenues and opportunities

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