Trabecular Bone Score Change Differs with Regard to 25(OH)D Levels in Patients Treated for Adult-Onset Growth Hormone Deficiency

Kužma, Martin; Binkley, Neil; Bednárová, Adriana; Killinger, Zdenko; Vaňuga, Peter; Payer, Juraj

doi:10.4158/ep151183.or

Cited by 12 publications

(4 citation statements)

References 37 publications

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“…Bone calcium stimulates osteoblast-and osteoclast-mediated release regulates calcium ion concentration in the body at a normal level. Research has shown that 25(OH)D is correlated with BMD [27,28]; however, additional studies have also found that 25 (OH) D has no correlation with BMD [29,30]. Generally speaking, our study found significant difference in the creatinine, eGFR, PTH, β-CTX and 25(OH)D levels between the osteoporosis and control groups.…”

Section: Discussioncontrasting

confidence: 60%

Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

Ma¹,

Li²,

Yao³

et al. 2020

Oncotarget

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Section: Discussioncontrasting

confidence: 60%

Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

Ma¹,

Li²,

Yao³

et al. 2020

Oncotarget

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“…V našej práci sa nám podarilo dokázať, že u pacientov s deficitom RH v dospelosti dochádza po liečbe RH k vzostupu nielen BMD, ale aj trabekulárneho kostného skóre (TBS), ktoré je nepriamym markerom trabekulárnej kostnej mikroarchitektoniky, a teda aj kvality kosti [22]. Zároveň sme v ďalšej analýze potvrdili, že k adekvátnemu nárastu TBS po liečbe RH môže dôjsť len ak majú pacienti súčasne dostatočnú hladinu vitamínu D [27].…”

Section: Vplyv Terapie Rh Na Kvalitu Kostiunclassified

Issues related to secondary osteoporosis associated with growth hormone deficiency in adulthood

Kužma¹,

Jackuliak²,

Killinger³

et al. 2017

Vnitr Lek

Self Cite

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Rastový hormón (RH) je najviac zastúpeným hormónom spomedzi všetkých hormónov hypofýzy. RH produkujúce bunky sa vyskytujú v adenohypofýze v 50% zastúpení. Sekrécia RH sa znižuje s vekom, pričom v strednom veku tvorí sekrécia RH 15 % hodnôt v puberte. RH indukuje proteosyntézu, znižuje glukózovú toleranciu, stimuluje lipolýzu vedúcu k zvýšeným hladinám cirkulujúcich mastných kyselín, podporuje retenciu sodíka, draslíka a vody zvyšuje hladiny anorganických fosfátov v sére [1]. Stavy spojené s deficitom RH u dospelýchStavy spojené s deficitom RH u dospelých tvoria: ochorenia hypofýzy -viac ako 90 %, zvyčajne spôsobených tumorom hypofýzy (benígne -najčastejšie adenóm), chirurgickým zákrokom alebo rádioterapiou tumoru hypofýzy iné príčiny -zahŕňajú traumu, tuberkulózu, histiocytózu X, hemochromatózu, lymfocytovú hypofyzitídu a infiltratívne ochorenia, ako je sarkoidóza idiopatické príčiny -zriedkavé [1] Lineárny rast kostí zvyšuje RH ako výsledok komplexných hormonálnych reakcií, zahrňujúcich najmä efekt

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“…The advantages of TBS compared to the other proposed techniques mainly resides in the use of a non-invasive investigation, performed in the same place as the standard densitometric examination, without exposing the patient to additional radiations, with a (very) low burden on health care costs. The evaluation of TBS has been proposed, in association with dual-energy x-ray absorptiometry (DXA), for the study of bone quality in various endocrine disorders such as primary hyperaldosteronism, Cushing’s syndrome and subclinical hypercortisolism, primary hyperparathyroidism, GH deficiency, as well as diabetes mellitus, proving in some cases more reliable than BMD alone in identifying patients with a higher risk of fractures [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients

Nazzari

Casabella

Paolino

et al. 2022

JCM

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Although GH and IGF-1 excess has a controversial impact on bone mineral density (BMD), acromegalic patients display variable degrees of bone structure impairment. In this study, we aim to investigate the usefulness of trabecular bone score (TBS), compared to BMD, in identifying acromegalic patients with impaired lumbar spine trabecular microarchitecture. Forty-four acromegalic patients were investigated for disease control, metabolic and gonadal status, bone metabolism parameters, and the presence of vertebral fractures (VFs). Patients and matched healthy controls underwent BMD and TBS examination. Mean TBS values were lower in patients than in controls (p < 0.001), without significant differences in mean lumbar and femoral BMD. TBS values were significantly higher in controlled patients compared to the uncontrolled ones (p = 0.012). No significant differences were found in bone markers with respect to disease control. Mean TBS or lumbar BMD did not significantly differ in patients with or without VFs (prevalence 11.4%). TBS and BMD levels were lower in hypogonadal patients compared to the eugonadal ones (p = 0.030 and p < 0.001, respectively). In conclusion, TBS values are significantly lower in patients than in controls, confirming the presence of impaired lumbar spine trabecular bone in acromegaly. Both uncontrolled disease and hypogonadism contribute to TBS deterioration in acromegaly.

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Trabecular Bone Score Change Differs with Regard to 25(OH)D Levels in Patients Treated for Adult-Onset Growth Hormone Deficiency

Cited by 12 publications

References 37 publications

Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

Issues related to secondary osteoporosis associated with growth hormone deficiency in adulthood

Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients

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