Global epidemiology of nonalcoholic fatty liver disease: Meta‐analytic assessment of prevalence, incidence, and outcomes

Lonardo, Amedeo; Byrne, Christopher D.; Caldwell, Stephen H.; Cortez‐Pinto, Helena; Targher, Giovanni

doi:10.1002/hep.28584

Cited by 121 publications

(91 citation statements)

References 5 publications

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“…Nonalcoholic fatty liver disease (NAFLD) is becoming a global epidemic, affecting about 25% adult population worldwide . NAFLD encompasses a spectrum of liver diseases, ranging from isolated steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma (HCC) .…”

Section: Introductionmentioning

confidence: 99%

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Qian

Yao

et al. 2019

Liver International

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Background & Aims Nonalcoholic fatty liver disease encompasses isolated steatosis or nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH). NASH develops from isolated steatosis with obscure driving forces. We aim to identify key factors promoting this transition. Methods Following 21‐week of high‐fat diet feeding, obese mice were classified into two groups termed as isolated steatosis and NASH based on hematoxylin‐eosin staining of liver histology. The integrated multi‐omics analysis of lipidome, transcriptome and gut microbiome were performed in mice with isolated steatosis and NASH, and confirmed in human samples. Results Livers in mice with NASH lost most lipids, and the transcriptional landscape was also changed dramatically in mice with NASH in relative to mice with isolated steatosis. Plasma lipidome analysis demonstrated a very clear difference between these two groups of mice, which was partially recapitulated in serum of patients with isolated steatosis and NASH. The microbiota composition revealed that Bacteroides genus and Bacteroides uniformis species decreased while Mucispirillum genus and Mucispirillum schaedleri species increased largely in mice with NASH. More importantly, we found that Bacteroides uniformis correlated positively with triglycerides (TGs) and negatively with free fatty acids (FFAs) and PE(18:1/20:4), while Mucispirillum schaedleri correlated positively with FFAs, LysoPC(20:3), LysoPC(20:4) and DG(16:1/18:2). Mechanically, administration of Bacteroides uniformis increased specific TGs, and decreased hepatic injury and inflammation in diet‐induced mice. Conclusions Overall, through multi‐omics integration, we identified a microbiota‐lipid axis promoting the initiation of NASH from isolated steatosis, which might provide a novel perspective on NASH pathogenesis and treatment.

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Section: Introductionmentioning

confidence: 99%

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Qian

Yao

et al. 2019

Liver International

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“…A recent meta-analysis reported that worldwide prevalence of NAFLD was 25.24%, mostly observed in the Middle East and South America [2]. Unfortunately, the prevalence of this disease has increased at an alarming rate in recent decades due to lifestyle changes (physical activities, diet) and rise of obesity [3].…”

Section: Introductionmentioning

confidence: 99%

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

Rafiei

Bemanian

Rafiei

et al. 2018

Romanian Journal of Internal Medicine

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“…Liver ultrasonography is one of the most accepted methods used for NAFLD screening as it is reproducible, harmless and cheaper than other imaging techniques, eg CT scanning and proton magnetic resonance imaging . Screening NAFLD with ultrasonography among high‐risk individuals (eg age>50 years, T2DM and MetS) is recommended in European countries . Previously, systematic screening of NAFLD in high‐risk populations such as T2DM and obese patients is not recommended because of limited knowledge of effective NAFLD management .…”

Section: Introductionmentioning

confidence: 99%

Clinical risk scoring for predicting non‐alcoholic fatty liver disease in metabolic syndrome patients (NAFLD‐MS score)

Saokaew

Kanchanasuwan

Apisarnthanarak

et al. 2017

Liver International

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Global epidemiology of nonalcoholic fatty liver disease: Meta‐analytic assessment of prevalence, incidence, and outcomes

Cited by 121 publications

References 5 publications

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

Clinical risk scoring for predicting non‐alcoholic fatty liver disease in metabolic syndrome patients (NAFLD‐MS score)

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