Ascorbylperoxide Contaminating Parenteral Nutrition Is Associated With Bronchopulmonary Dysplasia or Death in Extremely Preterm Infants

Mohamed, Ibrahim; Elremaly, Wesam; Rouleau, Thérèse; Lavoie, Jean-Claude

doi:10.1177/0148607116643704

Cited by 20 publications

(43 citation statements)

References 40 publications

(47 reference statements)

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“…Factorial analysis of variance (ANOVA) was used for the orthogonal comparisons (± light exposure × lipid emulsions); the F values are reported. The homoscedasticity was confirmed using Bartlett's chi. This conformation was reached with natural logarithm transformation of the GSH/GSSG values.…”

Section: Methodsmentioning

confidence: 81%

“…A recent meta‐analysis on photo‐protection of PN reported a reduction of the mortality by half in premature infants receiving PN . In clinical routine, an adequate protection against light exposure is very hard to achieve . Some teams are working to find new ways to protect PN from the ambient light that will be easy to use in clinical routine.…”

Section: Discussionmentioning

confidence: 99%

“…The Guinea pig has been frequently used in the last few years as a neonatal animal model of parenteral nutrition, especially for understanding the impact of PN or components of PN or oxidant molecules generated in PN on pulmonary oxidative stress deriving from free radicals or peroxides as well as on alveolarization . Several findings from this model have found a match in premature infants . In addition, its lipid metabolism is close to humans, and for this reason, it is proposed as a suitable model for lipid study …”

Section: Methodsmentioning

confidence: 99%

“…Parenteral nutrition (PN) is essential for the survival of infants born before 30 weeks of gestation because of the immaturity of their gastro‐intestinal system. However, PN is associated with the development of bronchopulmonary dysplasia (BPD) . In newborn animals, absence of an adequate photo‐protection of PN induces a hypo‐alveolarization, the main characteristic feature of BPD, following an exaggerated apoptosis .…”

Section: Introductionmentioning

confidence: 99%

“…However, PN is associated with the development of bronchopulmonary dysplasia (BPD). [1][2][3] In newborn animals, absence of an adequate photo-protection of PN induces a hypoalveolarization, the main characteristic feature of BPD, following an exaggerated apoptosis. 4,5 The ambient light exposure favors the generation of peroxides, especially H 2 O 2 and ascorbylperoxide from oxidation of ascorbate, 5,6 and aldehydes, such as 4-hydroxynonenal, from peroxidation of polyunsaturated fatty acids (PUFA) in PN.…”

Section: Introductionmentioning

confidence: 99%

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Impact of SMOFLipid on Pulmonary Alveolar Development in Newborn Guinea Pigs

Lavoie

Mohamed

Nuyt

et al. 2018

J Parenter Enteral Nutr

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Section: Methodsmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of SMOFLipid on Pulmonary Alveolar Development in Newborn Guinea Pigs

Lavoie

Mohamed

Nuyt

et al. 2018

J Parenter Enteral Nutr

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Stability of glutathione added as a supplement to parenteral nutrition

Raichani

Guiraut

Morin

et al. 2022

J Parenter Enteral Nutr

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Background: Most very premature newborns (<32 weeks of gestation) receive parenteral nutrition (PN) that is inherently contaminated with peroxides. Oxidative stress induced by PN is associated with bronchopulmonary dysplasia, a main pathological complication in these infants who have weak antioxidant capacity to detoxify peroxides because of their glutathione deficiency. In animals, glutathione supplementation of PN prevented oxidative stress and alveolar loss (the main characteristic of bronchopulmonary dysplasia). Of its two forms-oxidized glutathione (GSSG) and reduced glutathione (GSH)-GSSG was used because of its better stability. However, a 30% loss of GSSG in PN is observed. The potentially high therapeutic benefits of GSSG supplementation on the health of very premature infants make the study of its stability highly important.Methods: GSSG was incubated in combination with the following components of PN: dextrose, multivitamins, Primene, and Travasol, and with cysteine, cystine, and peroxides, for 24 h. Total glutathione in these solutions was measured 0-24 h after the addition of GSSG. Results:The combination of cysteine and multivitamins caused the maximum loss of glutathione. The stability of GSSG was not affected by multivitamins. The cysteine was responsible for ∼20% of the loss of GSSG; in the presence of multivitamins, the loss reached >70%. Removing the cysteine prevented the degradation of glutathione. Conclusion:GSSG reacts with cysteine to form cysteine-glutathione mixed disulfide, another suitable glutathione substrate for preterm neonates. The study confirms that GSSG added to PN can potentially provide a precursor to de novo synthesis of glutathione in vivo.

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Biomarkers of lung alveolarization and microvascular maturation in response to intermittent hypoxia and/or early antioxidant/fish oil supplementation in neonatal rats

Marcelino

Cai

Wadowski

et al. 2023

Pediatric Pulmonology

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Objective: Extremely preterm infants experience frequent intermittent hypoxia (IH) episodes during oxygen therapy which causes significant damage to the lungs and curtails important signaling pathways that regulate normal lung alveolarization and microvascular maturation. We tested the hypothesis that early supplementation with fish oil and/or antioxidants in rats exposed to neonatal IH improves expression of lung biomarkers of alveolarization and microvascular maturation, and reduces IH-induced lung injury.Study Design/Methods: From birth (P0) to P14, rat pups were exposed to room air (RA) or neonatal IH during which they received daily oral supplementation with either: (1) olive oil (OO) (control); (2) Coenzyme Q10 (CoQ10) in OO; (3) fish oil; (4) glutathione nanoparticles (nGSH); or (5) fish oil +CoQ10. At P14 pups were placed in RA until P21 with no further treatment. RA controls were similarly treated. Lung growth and alveolarization, histopathology, apoptosis, oxidative stress and biomarkers of alveolarization and microvascular maturation were determined.Results: Neonatal IH was associated with reduced lung weights and severe histopathological outcomes. These effects were curtailed with fish oil and nGSH. nGSH was also protective against apoptosis, while CoQ10 prevented IH-induced ROS production. Of all treatments, nGSH and CoQ10 + fish oil-induced vascular endothelial growth factor 165 and CD31 (Platelet endothelial cell adhesion molecule-1), which are associated with angiogenesis. CoQ10 + fish oil improved alveolarization in RA and IH despite evidence of hemorrhage. Conclusions:The benefits of nGSH and CoQ10 + fish oil suggest an antioxidant effect which may be required to curtail IH-induced lung injury. Further clinical assessment of the effectiveness of nGSH is warranted.

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Ascorbylperoxide Contaminating Parenteral Nutrition Is Associated With Bronchopulmonary Dysplasia or Death in Extremely Preterm Infants

Abstract: Extremely preterm infants have low glutathione levels, which limit their capacity to detoxify AscOOH. Higher first-week urinary AscOOH levels are associated with an increased incidence of BPD or death.

Cited by 20 publications

References 40 publications

Impact of SMOFLipid on Pulmonary Alveolar Development in Newborn Guinea Pigs

Impact of SMOFLipid on Pulmonary Alveolar Development in Newborn Guinea Pigs

Stability of glutathione added as a supplement to parenteral nutrition

Biomarkers of lung alveolarization and microvascular maturation in response to intermittent hypoxia and/or early antioxidant/fish oil supplementation in neonatal rats

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