HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study

Maiers, Martin; Halagan, Michael; Joshi, Sangeeta; Ballal, HS; Jagannatthan, Latha; Damodar, Sharat; Periathiruvadi, Srinivasan; Narayan, Saranya; Khattry, Navin; Malhotra, Pankaj; Minz, Ranjana W.; Shah, Sandip; Rajagopal, Raghu; Cereb, Nezih; Yang, Soo Young; Parekh, Sunil; Mammen, Joy John; Daniels, Dolly; Weisdorf, Daniel J.

doi:10.1016/s2352-3026(14)70021-3

Cited by 34 publications

(16 citation statements)

References 16 publications

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“…In contrast, the European area TFR has remained low over the last 50 years (2.6 in 1960 to 1.5 in 2012) [30]. Furthermore, modeling of sibling match probability may add to ongoing efforts to characterize HCT activity in countries such as India [31], where the treatment is both accessible and the population in need is expected to be substantial [32]. In our modeling efforts, we only considered siblings as potential HLA-identical sources as siblings represent 99.5% of the domestic related donations reported to Center for International Blood and Marrow Transplant Research since December 2007.…”

Section: Discussionmentioning

confidence: 99%

On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source

Besse

Maiers

Confer

et al. 2016

Biology of Blood and Marrow Transplantation

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Prior studies of allogeneic hematopoietic cell transplantation (HCT) therapy for the treatment of malignant or nonmalignant blood disorders assume a 30% likelihood that a patient will find a match among siblings and, therefore, a 70% likelihood of needing an unrelated donor source. This study utilizes birth data and statistical modeling to assess the adequacy of these estimates to describe the probability among US population cohorts segmented by race/ethnicity and age, including ages of greatest HCT utilization. Considerable variation in the likelihood of an HLA-identical sibling was found, ranging from 13% to 51%, depending upon patient age and race/ethnicity. Low sibling match probability, compounded with increased genetic diversity and lower availability among unrelated donors, put the youngest minority patients at the greatest risk for not finding a suitable related or unrelated HCT donor. Furthermore, the present 40-year decline in birth rates is expected to lead to 1.5-fold decrease in access to a matched sibling for today's young adults (18 to 44 years of age) when they reach peak HCT utilization years (near age 61 years) versus their contemporary adult counterparts (44 to 64 years). Understanding the sibling match probability by race/ethnicity and age cohort leads to forecasting the demand for unrelated HCT sources.

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Section: Discussionmentioning

confidence: 99%

On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source

Besse

Maiers

Confer

et al. 2016

Biology of Blood and Marrow Transplantation

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“…HLA-B*58:01 allele frequencies are, for example, 0.81% for German (Schmidt et al, 2009), 0.65% for Polish (Schmidt et al, 2011), 1.02% for French (Gourraud et al, 2015), and-depending on region-between 2.5% and 7.5% for Indian individuals (Maiers et al, 2014 process for this approach. Based on these pilot experiences, the approach may be extended to other DKMS entities and/or other HLAassociated drug reactions.…”

Section: Pharmacog Ene Ti C S In Donor Reg Is Try Pr Ac Ti Cementioning

confidence: 93%

“…For example, carriers of the HLA‐B*58:01 allele have a substantially increased risk for severe cutaneous adverse reactions (SCAR) when exposed to allopurinol, the standard medication against elevated uric acid levels, one of the most often prescribed drugs overall (Aihara, ). HLA‐B*58:01 allele frequencies are, for example, 0.81% for German (Schmidt et al, ), 0.65% for Polish (Schmidt et al, ), 1.02% for French (Gourraud et al, ), and—depending on region—between 2.5% and 7.5% for Indian individuals (Maiers et al, ). If the HLA‐B*58:01 allele carrier status is known, allopurinol should not be prescribed unless no therapeutic alternatives exist.…”

Section: Pharmacogenetics In Donor Registry Practicementioning

confidence: 99%

Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)

Schmidt

Sauter

Baier

et al. 2020

Int J Immunogenetics

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DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non‐HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high‐throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.

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“…Finally, individuals from a diversity of ethnic backgrounds should be targeted for recruitment, as patients are more likely to find an HLA‐matched unrelated donor within their own ethnic groups . Many ethnic and racial minority groups experience lower rates of finding HLA‐matched donors, both within and outside of North America. This is due to the combination of smaller donor pools, disproportionate representation on individual registries and on the worldwide network, and ethnic/racial differences in genetic diversity and in attrition from stem cell donor databases .…”

Section: Introductionmentioning

confidence: 99%

Targeted recruitment of male donors for allogeneic haematopoietic cell transplantation: A review of the evidence

2018

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Many patients in need of a haematopoietic cell transplant cannot find a suitable HLA-compatible donor within their families and rely on volunteers who have registered as haematopoietic stem cell donors with a stem cell donor registry. Transplant physicians mostly prefer male donors for their patients when multiple donor options exist, and organizations recruiting donors are actively targeting males in their recruitment efforts. However, significant recruitment of female donors continues worldwide and appears to be increasing. In this review, the evidence underlying transplant physician preference for male donor selection is summarized. The review will inform donor recruitment organizations contemplating a change in strategy to target potential male registrants and will equip donor recruitment staff and volunteers with a resource to better understand their recruitment efforts.

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HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study

Cited by 34 publications

References 16 publications

On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source

On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source

Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)

Targeted recruitment of male donors for allogeneic haematopoietic cell transplantation: A review of the evidence

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