Review of the Ongoing Story of Appetite Suppressants, Serotonin Pathway, and Pulmonary Vascular Disease

Bazán, Isabel; Fares, Wassim H.

doi:10.1016/j.amjcard.2016.02.049

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…In the CNS, 5-HT is produced in the raphe nuclei of the brainstem and hypothalamus. By functioning as a neurotransmitter in CNS, 5-HT regulates mood (Naoi, Maruyama, & Shamoto-Nagai, 2017), sleep-wake behavior (Bazan & Fares, 2016), and food intake (Ge et al, 2017). In the periphery, 5-HT is mainly produced in the gut and pineal gland.…”

Section: Discussionmentioning

confidence: 99%

Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat

Han

Min

Wang

et al. 2017

J of Neuroscience Research

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Diabetic encephalopathy (DE), one of the most prevalent chronic complications of diabetes mellitus, is short of effective prevention and formidable therapeutic strategies. The aim of the present study is to reveal the imbalance of tryptophan (Trp) and its metabolites in streptozotocin (STZ)-induced experimental DE rats to underscore their critical values in clinical diagnosis of the disease.For this purpose, we first developed an accurate and appropriate simultaneous method for measuring Trp and its metabolites using liquid chromatography-tandem mass spectrometry, which was in accordance with the requirements of biological sample analysis. Secondly, a single STZ intraperitoneal injection was administered to male Sprague-Dawley rats, and their cognitive function was detected by Morris water maze tests. Cerebrospinal fluid (CSF), serum, and brain tissue were then collected for the determination of Trp and its metabolites. Compared with age-matched control rats, the levels of neuroprotective serotonin decreased significantly in the samples of cortices, hippocampi, striatum, CSF, and serums in the STZ-induced DE rats, while the levels of neurotoxic 3-hydroxykynurenine increased significantly. Moreover, analogous changes of both compounds were found in the central nervous system and peripheral blood of the STZ-induced DE rats. In conclusion, we established a quantitative method for the simultaneous detection of Trp and its metabolites, and we also present a critical elucidation of the nervous system dysfunction in DE.

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Section: Discussionmentioning

confidence: 99%

Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat

Han

Min

Wang

et al. 2017

J of Neuroscience Research

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“…Later, other appetite-suppressant drugs, including fenfluramine, benfluorex, and amphetamine derivatives, were associated with an increased risk of PAH development (2). The serotonin pathway has been implicated in anorexigensassociated pulmonary vascular disease (7).…”

Section: Discussionmentioning

confidence: 99%

Giant pulmonary artery aneurysm caused by sibutramine-associated pulmonary arterial hypertension: First case in the literature

Kültürsay¹,

Keskin²,

Karagöz³

et al. 2021

Anatolian J Cardiol

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“…The pathobiology of PAH is complex, with multiple cell types, molecules, and pathways being implicated to varying levels [6]. Pulmonary artery endothelial cell dysfunction is thought to underlie many of these pathogenic processes.…”

Section: Pulmonary Arterial Hypertensionmentioning

confidence: 99%

Pulmonary arterial hypertension in the setting of scleroderma is different than in the setting of lupus: A review

Bazán

Mensah

Rudkovskaia

et al. 2018

Respiratory Medicine

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Pulmonary hypertension (PH) is a clinical syndrome that is subdivided into five groups per the World Health Organization (WHO) classification, based largely on hemodynamic and pathophysiologic criteria. WHO Group 1 PH, termed pulmonary arterial hypertension (PAH), is a clinically progressive disease that can eventually lead to right heart failure and death, and it is hemodynamically characterized by pre-capillary PH and increased pulmonary vascular resistance in the absence of elevated left ventricular filling pressures. PAH can be idiopathic, heritable, or associated with a variety of conditions. Connective tissue diseases make up the largest portion of these associated conditions, most commonly systemic sclerosis (SSc), followed by mixed connective tissue disease and systemic lupus erythematous. These etiologies (namely SSc and Lupus) have been grouped together as connective tissue disease-associated PAH, however emerging evidence suggests they differ in pathogenesis, clinical course, prognosis, and treatment response. This review highlights the differences between SSc-PAH and Lupus-PAH. After introducing the diagnosis, screening, and pathobiology of PAH, we discuss connective tissue disease-associated PAH as a group, and then explore SSc-PAH and SLE-PAH separately, comparing these 2 PAH etiologies.

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Review of the Ongoing Story of Appetite Suppressants, Serotonin Pathway, and Pulmonary Vascular Disease

Cited by 11 publications

References 24 publications

Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat

Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat

Giant pulmonary artery aneurysm caused by sibutramine-associated pulmonary arterial hypertension: First case in the literature

Pulmonary arterial hypertension in the setting of scleroderma is different than in the setting of lupus: A review

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