Efferocytosis of apoptotic human papillomavirus‐positive cervical cancer cells by human primary fibroblasts

Hermetet, François; Jacquin, Élise; Launay, Sophie; Gaiffe, Émilie; Couturier, Mélanie; Hirchaud, Fabienne; Sandoz, Patrick; Prétet, Jean‐Luc; Mougin, Christiane

doi:10.1111/boc.201500090

Cited by 28 publications

(26 citation statements)

References 70 publications

(129 reference statements)

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“…Hermetet et al reported that Macrophages engulf the late but not the early apoptotic populations of papilloma virus-infected cells (Hermetet et al, 2016). In this study, the levels of PtdSer exposure were almost the same in both the early and late apoptotic populations, suggesting involvement of other types of molecules associated with cell death in efferocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…Viral infection induces changes of cell surface molecules related to cell death, and macrophages can recognize these changes and engulf the affected cells. It has been reported that macrophages perform efferocytosis of cells infected with the influenza (Fujimoto et al, 2000; Hashimoto et al, 2007; Shiratsuchi et al, 2000; Watanabe et al, 2005, 2002, 2004; Mukherjee et al, 2017), papilloma (Hermetet et al, 2016), and Drosophila C viruses (Nainu et al, 2015; Nonaka et al, 2017), as well as Lymphocytic choriomeningitis virus (LCMV) (Alatery et al, 2010), and Human Immunodeficiency Virus Type 1 (HIV-1) (Akbar et al, 1994). …”

Section: Introductionmentioning

confidence: 99%

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Protein S and Gas6 induce efferocytosis of HIV-1-infected cells

et al. 2018

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Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular mechanisms are unknown. To elucidate the roles that efferocytosis of HIV-1-infected cells play in clearance of infected cells, we sought to identify molecules that mediate these processes. We found that protein S, present in human serum, and its homologue, Gas6, can mediate phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer, expressed on macrophages, to phosphatidylserine exposed on infected cells. Efferocytosis of live infected cells was less efficient than dead infected cells; however, a significant fraction of live infected cells were phagocytosed over 12 h. Our results suggest that efferocytosis not only removes dead cells, but may also contribute to macrophage removal of live virus producing cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein S and Gas6 induce efferocytosis of HIV-1-infected cells

et al. 2018

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“…Collectively, these results suggest the ability of these large EVs to transform recipient cell [36]. The same group also reported that late ABs are taken up by fibroblasts more efficiently than early ABs, nevertheless the phagocytic activity of these cells remain low compared to those exerted by professional phagocytic cells [37].…”

Section: Mucosal Hpvs and Extracellular Vesiclesmentioning

confidence: 67%

Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles

Chiantore

Mangino

Iuliano

et al. 2020

Cytokine & Growth Factor Reviews

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A B S T R A C TA small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as cofactors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role.

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“…Efficient resolution relies on phagocytic engulfment of apoptotic neutrophils by macrophages. Importantly, an early calcium flux in the macrophages is essential for formation of phagocytic cup, internalization of dead cells, and initiation of anti-inflammatory signaling (31)(32)(33)(34). Calcium mobilization is required for transition of proinflammatory macrophages into anti-inflammatory or proresolving ones (35,36).…”

Section: Discussionmentioning

confidence: 99%

Myc‐nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation

et al. 2018

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A key event required for effective resolution of inflammation is efferocytosis, which is defined as phagocytic removal of apoptotic cells mostly by macrophages acquiring an alternatively activated phenotype (M2). c-Myc has been reported to play a role in alternative activation of human macrophages and is proposed as one of the M2 macrophage markers. We found that M2-like peritoneal macrophages from zymosan A-treated mice exhibited a marked accumulation of Myc-nick, a truncated protein generated by a Calpain-mediated proteolytic cleavage of full-length c-Myc. Further, ectopic expression of Myc-nick in murine bone marrow-derived macrophages promoted the M2 polarization and, consequently, enhanced their efferocytic capability. Notably, Myc-nick-induced efferocytosis was found to be tightly associated with α-tubulin acetylation by K acetyltransferase 2a (Kat2a/Gcn5) activity. These findings suggest Myc-nick as a novel proresolving mediator that has a fundamental function in maintaining homeostasis under inflammatory conditions.-Zhong, X., Lee, H.-N., Kim, S. H., Park, S.-A., Kim, W., Cha, Y.-N., Surh, Y.-J. Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation.

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Efferocytosis of apoptotic human papillomavirus‐positive cervical cancer cells by human primary fibroblasts

Abstract: Our results highlight the cellular and molecular mechanisms of fibroblast-mediated clearance of apoptotic tumour cells. Consequences regarding alternative mechanism of carcinogenesis or tumour progression should be addressed.

Cited by 28 publications

References 70 publications

Protein S and Gas6 induce efferocytosis of HIV-1-infected cells

Protein S and Gas6 induce efferocytosis of HIV-1-infected cells

Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles

Myc‐nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation

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