Comment on: Acute and chronic hepatitis E virus infection in human immunodeficiency virus‐infected U.S. women

Evaluation of an antigen assay for diagnosing acute and chronic hepatitis E genotype 4 infection

“…Anti‐HEV IgM and IgG might not be detected in chronic hepatitis E patients, bringing a challenge for HEV diagnosis . Recent studies have shown that HEV infections in hematological patients receiving immunosuppressive therapy, in solid organ transplant patients and in HIV patients, can lead to chronic hepatitis . Additionally, the prevalence of chronic HEV infection is high in immunosuppressed children .…”

“…19,20 Recent studies have shown that HEV infections in hematological patients receiving immunosuppressive therapy, in solid organ transplant patients and in HIV patients, can lead to chronic hepatitis. [21][22][23][24][25][26][27][28][29][30] Additionally, the prevalence of chronic HEV infection is high in immunosuppressed children. 31 A particularly serious issue is that chronic HEV infection can cause rapidly progressive cirrhosis.…”