Vagus nerve ultrasound in a patient with amyotrophic lateral sclerosis

Tawfik, Eman A.

doi:10.1002/mus.25126

Cited by 17 publications

(16 citation statements)

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“…Our study demonstrates higher sensitivity of a more precise method of CSA measurement compared to the standard methods in detecting age‐ and gender‐related variation of nerves of small caliber. The precise measurement of the CSA of such nerves is of increasing clinical relevance for the monitoring of neurodegenerative disorders . Most contemporary HR‐US systems, including the system used here, allow for online measurements of CSA only as full square millimeters .…”

Section: Discussionmentioning

confidence: 99%

“…The precise measurement of the CSA of such nerves is of increasing clinical relevance for the monitoring of neurodegenerative disorders. 12,[18][19][20] Most contemporary HR-US systems, including the system used here, allow for online measurements of CSA only as full square millimeters. 21 However, HR-US systems are now available that provide online area measures as square millimeters with 1 or more (up to 3) digits after the decimal point, an option that can be chosen by the user in the system settings.…”

Section: Discussionmentioning

confidence: 99%

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Differential age‐, gender‐, and side‐dependency of vagus, spinal accessory, and phrenic nerve calibers detected with precise ultrasonography measures

Walter

Tsiberidou

2019

Muscle and Nerve

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Introduction: The standard ultrasonographic measurement tools (trace, ellipse) of cross‐sectional areas (CSAs) of very small nerves typically yield rough measures in full square millimeters. Methods: In 70 volunteers, the elliptically shaped CSAs of mid‐cervical vagus, accessory, and phrenic nerves were estimated with three methods: 2 on‐board tools (area tracing, ellipse fitting) and an off‐line calculation of the CSA after on‐board measuring of its long‐axis and short‐axis diameters both displayed with 1‐2 digits following the decimal point. Results: CSA measures of all mid‐cervical nerves obtained with the precise approach were smaller than the two standard measures (each P < 0.001). Larger CSA of right compared to left vagus nerve was detected with all methods. However, decrease of accessory and phrenic nerve CSAs with increasing age and larger size of vagus nerve CSA in women vs. men were evident only with precise measures. Discussion: Small nerve CSA should preferably be estimated with precise measures. Muscle Nerve 59:486–491, 2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential age‐, gender‐, and side‐dependency of vagus, spinal accessory, and phrenic nerve calibers detected with precise ultrasonography measures

Walter

Tsiberidou

2019

Muscle and Nerve

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“…As there is preliminary sonographic evidence from a case report that the vagus nerve is reduced in size in ALS patients with bulbar involvement, the aim of present study was to confirm possible changes in the vagus nerve size in a series of bulbar affected ALS patients. 6 This study could be the basis for further research of vagus nerve changes in ALS patients as…”

Section: Introductionmentioning

confidence: 88%

Ultrasound Detection of Vagus Nerve Atrophy in Bulbar Amyotrophic Lateral Sclerosis

Holzapfel

Naumann

2020

Journal of Neuroimaging

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BACKGROUND AND PURPOSE: Neuromuscular ultrasound in amyotrophic lateral sclerosis (ALS) is of increasing interest. As bulbar symptoms are commonly developed by most ALS patients during disease, the aim of our study was to find possible sonographic changes of vagus nerve size in bulbar affected ALS patients. METHODS: We investigated 24 ALS patients and 19 controls without neuromuscular disorders. In ALS patients, bulbar affection was documented clinically (eg, dysarthria, dysphagia, and fasciculations) or subclinically using ultrasound and electromyography of bulbar muscles. Vagus nerve ultrasound was performed in all participants bilaterally at the level of the thyroid gland. RESULTS: The cross-sectional area (CSA) of the vagus nerve in bulbar affected ALS patients (mean CSA right/left 1.9 ± .7 mm 2 /1.8 ± .6 mm 2) was significantly reduced on both sides compared to controls (mean CSA right/left 2.2 ± .6 mm 2 /2.0 ± .3 mm 2)-right: P = .0387, left: P = .0386. Receiver operating characteristic curve analysis of the vagus nerve CSA yielded a sensitivity of 66.7% and a specificity of 63.2% (cutoff value 1.85 mm 2). Vagus nerve CSA did not correlate significantly with age in controls (right: P = .45, left: P = .66). In controls and ALS patients, there was no significant difference of vagus nerve CSA between the right and left sides (controls: P = .43; patients: P = .86). CONCLUSION: Our study demonstrates vagus nerve atrophy in bulbar affected ALS patients. Further studies are warranted investigating the relevance of our finding for monitoring disease progression in ALS.

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“…Cranial nerve ultrasonography is an emerging subdomain of neuromuscular ultrasound . Diagnostic ultrasound of the vagus nerve for the assessment of neuropathy has been addressed in few studies . Our aim in this study was to assess the changes that may occur in the vagus nerve via ultrasound in diabetic patients, including those with and those without autonomic symptoms.…”

Section: Introductionmentioning

confidence: 99%