New Perspectives on Neuroengineering and Neurotechnologies: NSF-DFG Workshop Report

Moritz, Chet T.; Ruther, Patrick; Goering, Sara; Stett, Alfred; Ball, Tonio; Burgard, Wolfram; Chudler, Eric H.; Rao, Rajesh P. N.

doi:10.1109/tbme.2016.2543662

Cited by 25 publications

(12 citation statements)

References 161 publications

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“…Intraspinal implant of human induced pluripotent stem cells, combined with fibrin matrix and a trophic factor cocktail, elicited neuronal differentiation and long-distance axon growth [336]. Integrating therapeutic stimulation or brain-computer interfaces with biological therapies could also prove effective [337,338]. For instance, flexible nanowires have been developed that are biocompatible and stretchable for integration in the spinal cord; these enabled optoelectronic interrogation of spinal cord circuits in chronically implanted, free-moving mice [339].…”

Section: Future Directions: Manipulating Glial Responses To Improve Nmentioning

confidence: 99%

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

2018

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Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he correctly surmised that microglia in pathologic central nervous system (CNS) were "voracious monsters" that helped clean the tissue. Although these historical predictions were remarkably accurate, innovative technologies have revealed novel molecular, cellular, and dynamic physiologic aspects of CNS glia. In this review, we integrate recent findings regarding the roles of glia and glial interactions in healthy and injured spinal cord. The three major glial cell types are considered in healthy CNS and after spinal cord injury (SCI). Astrocytes, which in the healthy CNS regulate neurotransmitter and neurovascular dynamics, respond to SCI by becoming reactive and forming a glial scar that limits pathology and plasticity. Microglia, which in the healthy CNS scan for infection/damage, respond to SCI by promoting axon growth and remyelination-but also with hyperactivation and cytotoxic effects. Oligodendrocytes and their precursors, which in healthy tissue speed axon conduction and support axonal function, respond to SCI by differentiating and producing myelin, but are susceptible to death. Thus, post-SCI responses of each glial cell can simultaneously stimulate and stifle repair. Interestingly, potential therapies could also target interactions between these cells. Astrocyte-microglia cross-talk creates a feed-forward loop, so shifting the response of either cell could amplify repair. Astrocytes, microglia, and oligodendrocytes/precursors also influence post-SCI cell survival, differentiation, and remyelination, as well as axon sparing. Therefore, optimizing post-SCI responses of glial cells-and interactions between these CNS cells-could benefit neuroprotection, axon plasticity, and functional recovery.

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Section: Future Directions: Manipulating Glial Responses To Improve Nmentioning

confidence: 99%

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

2018

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“…Extensive integration between advanced neuroelectrodes and ultraminiaturized electronics will make bidirectional braine computer interfaces possible. 46 Although still largely experimental, these types of advances will revolutionize medicine and surgery as practiced today.…”

Section: Artificial Intelligencementioning

confidence: 99%

The Future of Skull Base Surgery: A View Through Tinted Glasses

et al. 2020

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…Morein-Zamir and Sahakian (2010 [197]) explore the connection between neuroethics, education and public engagement. The authors argue that because of the impact of neuroscience on society and the key role of education to responsible thinking formal curricula in schools and universities in neuroethics and public engagement would be warranted (Hankins, 2013[198]).…”

Section: Educationmentioning

confidence: 99%

Neurotechnology and society

2017

OECD Science, Technology and Industry Policy Papers

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This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area. The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law.

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New Perspectives on Neuroengineering and Neurotechnologies: NSF-DFG Workshop Report

Cited by 25 publications

References 161 publications

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

The Future of Skull Base Surgery: A View Through Tinted Glasses

Neurotechnology and society

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