Erratum to: Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter

Abstract

Fig. 3 ER beta recruits corepressors to the Sp-1 site in the ER alpha gene promoter. a Nuclear extracts from MCF-7 cells transfected with either empty vector or ER beta expression plasmid were incubated with a double-stranded Sp-1 specific sequence probe labeled with [c 32 P] ATP and subjected to elettrophoresis in a 6 % polyacrylamide gel (lanes 1 and 4). Competition experiments were performed adding as competitor a 100-fold molar excess of unlabeled probe (lanes 2 and 11) or a 100-fold molar excess of unlabeled oligonucleotide containing a mutated Sp-1 motif (lane 3). Nuclear extracts from MCF-7 over-expressing ER beta were incubated with anti-NCoR

Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases

“…In addition, the expression level of these receptors determines the direction of different signaling pathways [75]. The increased level of ERβ decreases the level of ERα by downregulating its transactivation [161]. Considering that ERα and ERβ both mediate estrogen effects, there is an emergent need to define a new receptor status for breast cancer in clinical routines that include the status of ERβ1 and/or ERβ2 [162].…”