2016
DOI: 10.1007/s12250-015-3680-6
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Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens

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Cited by 5 publications
(4 citation statements)
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“…However, an interesting finding of this study is that, despite not being significantly different, the histopathological scores were slightly better in the group primed with pVP2 and boosted with rVP2. This contrasts with the results of the humoral evaluation, although is consistent with other reports that found that less or even no detectable antibodies did not obliterate the ability of certain vaccine candidates to protect in both avian [11,36,37] and mammalian [38,39] models.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…However, an interesting finding of this study is that, despite not being significantly different, the histopathological scores were slightly better in the group primed with pVP2 and boosted with rVP2. This contrasts with the results of the humoral evaluation, although is consistent with other reports that found that less or even no detectable antibodies did not obliterate the ability of certain vaccine candidates to protect in both avian [11,36,37] and mammalian [38,39] models.…”
Section: Discussionsupporting
confidence: 88%
“…In order to overcome these issues, different immunogens such as subunit, DNA or live viral-vectored vaccines have been rationally designed and evaluated [6,7]. Our group has had successful experiences immunizing chickens with VP2 protein produced both in Nicotiana benthamiana plants [8] and through non replicative poxviral vectors [9][10][11].…”
Section: Introductionmentioning
confidence: 99%
“…Despite the fact that not all chicken had specific anti-VP2 antibodies and that VN titers might not be as high as the ones observed when the immunogen is im administered, we were able to see protection against viral infection evidenced by BB ratio, T-cell infiltration, and viral load in bursa, in all but one animal. Although neutralizing antibodies have been considered as the most relevant tool to protect against IBDV infection, there is evidence that protection can be achieved in their absence, suggesting that other mechanisms might also be relevant in the defense against IBDV ( Yeh et al, 2002 ; Ingrao et al, 2013 ; Zanetti et al, 2016 ). On the other hand, in this experiment, we did not measure mucosal IgA in the intestine, which is one of the desirable immune responses pursued by oral vaccines.…”
Section: Discussionmentioning
confidence: 99%
“…Other viral vector vaccines. A canarypox vector virus has been developed for chickens as a vaccine against IBD in Argentina (188,358,359). This vector is poorly or nonreplicative in chickens and therefore, high dose is required to induce protection (358).…”
Section: New Technology Vaccinesmentioning
confidence: 99%