Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis

Shen, Yang; Liu, Yun; Xia, Ke; Kang, Hou‐Yong; Hu, Guohua; Hong, S.K.

doi:10.12932/ap0630.34.2.2016

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…4 ). These include cytokines (IL13, 100 101 IL4, 102 IL12B, 103 IL17A, 103 , 104 17F, 102 IL6, 105 IL27 106 ) cytokine receptors (IL23R, 107 IL12RB1, 108 and EBI3 109 ) immunity pathway molecules (JAK1, 110 FCRL3, 111 TNFSF4, 112 CTLA4, 113 CD14, 114 TNFA, 115 PBX2, 116 TAP1, 117 TNFAIP3, 118 FAM167A-BLK, 112 GATA3, 119 IRAK4, 120 RORA, 103 TGFB1, 121 and FOXP3 109 ), allergic airway inflammation and airway remodelling molecular genes (BDNF, 122 CYP2R1, 123 VDR, 123 ACE, 124 125 126 MRPL4, 115 ADAM33 127 128 ), and others (rs4982958 at 14q11.2). 129 Fig.…”

Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

239

198

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Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

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Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

239

198

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“…JAK1 and JAK3 play crucial roles in the initiation of inflammatory responses [14]. Studies have reported that the JAK-STAT pathway in asthma [15] and in allergic rhinitis [16]. It is known that allergic diseases are predominantly characterized by elevated levels of IL-4, IL-5, IL-13 and IL-31.…”

Section: Introductionmentioning

confidence: 99%

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

Huang

Han

et al. 2019

Korean J Physiol Pharmacol

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Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal transduction and activation of transcription (JAK/STAT) signaling is found to be involved in asthma. Magnolol is a plant-derived bioactive compound with several pharmacological effects. The study aimed to assess the effects of magnolol in ovalbumin (OVA)-induced asthmatic model. BALB/c mice were sensitized and challenged with OVA. Magnolol (12.5, 25, or 50 mg/kg body weight) was administered to separate groups of animals. Dexamethasone was used as the positive control. Cellular infiltration into the bronchoalveolar lavage fluid (BALF) were reduced on magnolol treatment. The levels of Th2 and Th17 cytokines were reduced with noticeably raised levels of interferon gamma. Lung function was improved effectively along with restoration of bronchial tissue architecture. OVA-specific immunoglobulin E levels in serum and BALF were decreased by magnolol. Magnolol reduced Th17 cell population and effectively modulated the JAK-STAT and Notch 1 signaling. The results suggest the promising use of magnolol in therapy for allergic asthma.

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“…The JAK-STAT pathway transmits growth factors and cytokines, which are essential in autoimmune disorders and inflammation [27]. JAK1 appears to be one of these kinases that is particularly important in pruritic dermatitis, allergic rhinitis, asthma, and inflammatory bowel disease [28][29][30][31]. Small-molecule JAKis have demonstrated efficacy in treating the aforementioned disorders [30,32,33].…”

Section: Clinical Use Of Jak Inhibitionmentioning

confidence: 99%

FDA-Approved Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) Inhibitors for Managing Rheumatoid Arthritis: A Narrative Review of the Literature

Potlabathini,

Pothacamuri,

Bandi

et al. 2024

Cureus

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Rheumatoid arthritis (RA) is a complex autoimmune disease causing chronic joint inflammation and, in more serious cases, organ involvement. RA typically affects people between the ages of 35 and 60; however, it can also afflict children younger than the age of 16 years and can also demonstrate a pattern of remission later in the disease course. Non-steroidal anti-inflammatory drugs, glucocorticoids, exercise, and patient education are all used in the management of RA, which is divided into symptomatic management and disease-modifying management (disease-modifying antirheumatic drugs) to reduce pain and inflammation, thereby preserving joint function. Janus kinase inhibitors (JAKis) have led to a substantial improvement in the management of RA. By specifically targeting the JAK-signal transducer and activator of transcription pathway, which is essential for immunological modulation, these inhibitors also demonstrate promise in treating various autoimmune illnesses, including inflammatory bowel diseases, giant cell arteritis, ankylosing spondylitis, and psoriatic arthritis. Tofacitinib, baricitinib, upadacitinib, peficitinib, delgocitinib, and filgotinib are examples of FDA-approved JAKis that have distinct properties and indications for treating a range of autoimmune illnesses. JAKis demonstrate a promising treatment approach for managing RA and other autoimmune diseases while enhancing patient outcomes and quality of life. However, due to major safety concerns and the need for long-term success, meticulous patient monitoring is essential.

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Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis

Cited by 5 publications

References 19 publications

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

FDA-Approved Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) Inhibitors for Managing Rheumatoid Arthritis: A Narrative Review of the Literature

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