Socioeconomic value of intervention for chronic pain

Takura, Tomoyuki; Shibata, Masahiko; Inoue, Shinsuke; Matsuda, Yoichi; Uematsu, Hiroyuki; Yamada, Keiko; Ushida, Takahiro

doi:10.1007/s00540-016-2162-9

Cited by 9 publications

(10 citation statements)

References 18 publications

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“…Also, no clinical measures were available in this survey database and it was not possible to control for all factors that may have affected results (e.g., unmeasured variables correlated with the presence of CLBP in the study). Nonetheless, self-reported measures were routinely used to collect information on the variables used in this study in similar prior studies 4,11,12,14,18,35,36. Also, current study findings align with research using hospital financial service and work injury compensation data 17,18.…”

Section: Discussionsupporting

confidence: 67%

“…Nonetheless, self-reported measures were routinely used to collect information on the variables used in this study in similar prior studies 4,11,12,14,18,35,36. Also, current study findings align with research using hospital financial service and work injury compensation data 17,18. Finally, because of the cross-sectional nature of the study, a causal relationship between CLBP and the outcomes could not be established.…”

Section: Discussionmentioning

confidence: 63%

“…The results from the current study can be used for the purposes of evaluating interventions for CLBP, which have been reported to attenuate suffering and economic burden in patients with LBP 16–18. Further, longitudinal research to evaluate the effectiveness of different interventions for the management of CLBP on patient outcomes and the associated economic burden is needed.…”

Section: Resultsmentioning

confidence: 98%

“…Literature from Japan and other countries has shown that interventions targeting back pain are able to reduce both suffering and economic burden 16–18. However, there are few data that provide estimates of the economic impact of CLBP in Japan, specifically those that policy makers could use to evaluate the impact of different pharmaceutical and non-pharmaceutical interventions for people with CLBP.…”

Section: Introductionmentioning

confidence: 99%

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The economic and humanistic costs of chronic lower back pain in Japan

Montgomery¹,

Sato²,

Nagasaka³

et al. 2017

CEOR

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BackgroundFew data are available that provide estimates of the economic impact of chronic lower back pain (CLBP) in Japan. The current study estimated the patient burden and the direct and indirect medical costs associated with CLBP in Japan using data from a large cross-sectional patient survey. CLBP was hypothesized to be associated with a considerable burden of illness and a large economic impact.MethodsStudy participants completed the Japan National Health and Wellness Survey in 2014, which included measures of health-related quality of life (HRQoL), work impairment, impairment to daily activities, and healthcare service use. Data from those reporting CLBP (N=392) were contrasted against those from matched controls without back pain, using age and sex-adjusted models.ResultsCLBP patients reported significantly lower HRQoL relative to matched controls. Age-and sex-adjusted models estimated mean annual per patient direct and indirect costs attributable to CLBP to be ¥1,820,297 ($15,239 or €12,551) and ¥1,479,899 ($12,389 or €10,203), respectively, with the majority of direct costs related to hospital expenses (¥1,584,759, which is equivalent to $13,267 and €10,927). In estimating the economic impact of CLBP on society, the CLBP respondents were estimated to include 1,508,524 individuals when extrapolated to the Japanese population (815,461 of them employed). Ultimately, this represented approximately ¥1.2 trillion ($10 billion and €8.3 billion) per year in lost productivity at the time of this study.ConclusionThis study of patients with CLBP in Japan has shown it to be associated with a significant burden on patients and to have a considerable negative impact on the Japanese economy primarily driven by lost productivity. Further research on the effectiveness of interventions to improve the outcomes of those with CLBP is warranted.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The economic and humanistic costs of chronic lower back pain in Japan

Montgomery¹,

Sato²,

Nagasaka³

et al. 2017

CEOR

View full text Add to dashboard Cite

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“…The relieve effects of anti-epileptic drugs and NSAIDs are limited (2). The effect of nerve damage is possible to clear short-term, but it easily relapse and has poor therapeutic effect in second treatment (3). Opioids have a strong analgesic effect, but could easily cause addiction and drug dependence (4).…”

Section: Introductionmentioning

confidence: 99%

Impact of Botox-A SNAP-25 protein expression and the mechanism of inhibitory neurotransmitter imbalance in chronic sciatic nerve pain rat model

Ding

Wang

Ding

et al. 2017

Experimental and Therapeutic Medicine

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The Botox-A impact on the expression of SNAP-25 protein in rat chronic sciatic nerve pain model was assessed and the mechanism of inhibitory neurotransmitter imbalance was studied. A chronic constriction injury (CCI) model consisted of 30 healthy male rats. The rats were randomly divided into the sham-operated group, CCI group and BoNT/A intervention group, and during 1, 7 and 14 days we conducted mechanical withdrawal threshold (MWT) test and thermal withdrawal latency (TWL) test before and after operation. After 14 days, the animals were sacrificed. SNAP-25 protein expression level, mRNA subunit NR2B within excitatory neurotransmitter glutamate GLT and protein expression level, as well as GAT mRNA, the inhibitory GABA neurotransmitter transporter and protein expression level were studied by RT-polymerase chain reaction and western blot analysis. The difference between MWT and TWL at each point in time before and after operation showed no statistical significance (P>0.05) in the sham-operated group. For the CCI group at each time point, MWT and TWL were obviously lower than the sham-operated group and the difference was statistically significant (P<0.05) while the internal difference at each time point showed no statistical significance (P>0.05). The expression level of protein of SNAP-25 and NR2B mRNA in the CCI group was clearly higher than sham-operated group. Additionally, the expression level of GAT-1 mRNA and protein in CCI group was apparently lower than the sham-operated group. In conclusion, Botox-A helped reduce SNAP-25 within rat chronic sciatic nerve pain model thereby relieving pain.

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A Systematic Review of the Variation in Pain Catastrophizing Scale Reference Scores Based on Language Version and Country in Patients with Chronic Primary (Non-specific) Pain

et al. 2022

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Introduction This systematic review aimed to investigate variations of reference scores for the Pain Catastrophizing Scale (PCS) between language versions and between countries in patients with chronic primary pain (CPP) or chronic primary pain, not otherwise specified (CPP-NOS). Methods Electronic searches of the Ovid/Embase, Ovid/MEDLINE, and Ovid/PsycINFO databases were conducted to retrieve studies assessing PCS scores in adults with CPP or CPP-NOS proposed by the International Classification of Diseases, Eleventh Revision for any country where the translated PCS was available. The protocol for this systematic review was prospectively registered on the International Prospective Register of Systematic Reviews 2018 (registration number: CRD 42018086719). Results A total of 3634 articles were screened after removal of duplicates. From these, 241 articles reporting on 32,282 patients with chronic pain were included in the review. The mean (± standard deviation) weighted PCS score across all articles was 25.04 ± 12.87. Of the 12 language versions and 21 countries included in the review, the weighted mean PCS score in Asian languages or Asian countries was significantly higher than that in English, European, and other languages or Western and other countries. The highest mean score of the weighted PCS based on language was in Japanese (mean 33.55), and the lowest was in Russian (mean 20.32). The highest mean score of the weighted PCS based on country was from Japan (mean 33.55), and the lowest was from Australia (mean 19.80). Conclusion The weighted PCS scores for people with CPP or CPP-NOS were significantly higher in Asian language versions/Asian countries than in English, European and other language versions or Western and other countries. Supplementary Information The online version contains supplementary material available at 10.1007/s40122-022-00390-0.

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Socioeconomic value of intervention for chronic pain

Abstract: Based on our results, the EQ-5D is reliable for evaluating chronic pain in patients. The medico-economic balance was appropriate for all treatments provided in two comprehensive pain centers in Japan.

Cited by 9 publications

References 18 publications

The economic and humanistic costs of chronic lower back pain in Japan

The economic and humanistic costs of chronic lower back pain in Japan

Impact of Botox-A SNAP-25 protein expression and the mechanism of inhibitory neurotransmitter imbalance in chronic sciatic nerve pain rat model

A Systematic Review of the Variation in Pain Catastrophizing Scale Reference Scores Based on Language Version and Country in Patients with Chronic Primary (Non-specific) Pain

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