270 The effect of drugs on storage and release of serotonin and catecholamines in brain

Costa, E.; Brodie, Bernard B.

doi:10.1016/0006-2952(61)90450-6

Cited by 14 publications

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“…This can be explained by the fact that a-methylmetatyrosine does not deplete brain noradrenaline in monoamine oxidase-inhibited mice (Costa, Gessa, Hirsch, Kuntzman & Brodie, 1962). Bovet-Nitti & Bignami (1962) have reported that the pseudopregnancy provoked by reserpine could be completely prevented by prior administration of some monoamine oxidase inhibitors but their study does not exclude 5-hydroxytryptamine as a possible neurohumour in the regulation of the oestrous cycle whereas our study excludes this possibility, as a-methylmetatyrosine is a specific depletor of catecholamines in the dose tested (Costa et al, 1962b).…”

Section: Discussioncontrasting

confidence: 69%

A Study of Central Adrenergic Mechanisms in the Regulation of the Oestrous Cycle of Albino Mice

Bhargava

Gupta

1966

British Journal of Pharmacology and Chemotherapy

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These findings suggest that catecholamines are involved in the release of the luteinizing hormone releasing factor. If this is true, then any change in the catecholamine level of the brain would affect the oestrous cycle. In the present study the effect of those drugs which either change the catecholamine level or block the catecholamine receptors in the brain has been studied on the oestrous cycle of albino mice. METHODSFemale mice weighing from 18 to 32 g were used. They were given a diet containing wheat, yeast, cod liver oil (in the form of a paste) and green vegetables. The mice were screened for regularity of oestrous cycle for 20 days. Only those mice which showed regular oestrous cycle were selected for the study. Vaginal smears were made by the method used by Bhargava & Jaitly (1964). The smears were stained with Leishman's stain and examined under the microscope. The criteria used for differentiating the stages of the oestrous cycle were those of Allen (1922). Separate smear records were kept for each mouse.All the drugs were dissolved in distilled water and injected intraperitoneally. The drugs were given daily. The concentrations of the drugs were such that a volume of 0.015 ml./g of body weight was injected into each mouse. Each drug was injected for 15 days and the vaginal smears during this period were compared with the smear records of the same mice for the 15 days immediately preceding the treatment with the drug. Each mouse, therefore, served as its own control.The monoamine oxidase inhibitors were injected intraperitoneally, 1 hr before the administration of et-methylmetatyrosine into the mice receiving combined treatment.

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Section: Discussioncontrasting

confidence: 69%

A Study of Central Adrenergic Mechanisms in the Regulation of the Oestrous Cycle of Albino Mice

Bhargava

Gupta

1966

British Journal of Pharmacology and Chemotherapy

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“…Costa & Brodie (37) contend that depletion of brain catecholamines is not responsible for sedation by reserpine, since norepinephrine and dopamine could be selectively depleted without sedation by alpha-methylmetahydroxy tyrosine, while impairment of serotonin binding by other drugs is invariably associated with sedation. On the other hand the excitement caused by monoamine oxidase (MAO) inhibitors may be mediated by catecholamines.…”

Section: Indirect Phar M Acological Evidence Concerning Central Mediamentioning

confidence: 97%

Some Aspects of Central Nervous Pharmacology

Toman¹

1963

Annu. Rev. Pharmacol.

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Inhibitors of monoamine oxidase and decarboxylase of aromatic amino acids

Pletscher¹,

Gey²,

Burkard³

1966

5-Hydroxytryptamine and Related Indolealkylamines

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270 The effect of drugs on storage and release of serotonin and catecholamines in brain

Cited by 14 publications

References 0 publications

A Study of Central Adrenergic Mechanisms in the Regulation of the Oestrous Cycle of Albino Mice

A Study of Central Adrenergic Mechanisms in the Regulation of the Oestrous Cycle of Albino Mice

Some Aspects of Central Nervous Pharmacology

Inhibitors of monoamine oxidase and decarboxylase of aromatic amino acids

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