27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota

Hao, Ling; Wang, Lijing; Ju, Mengwei; Feng, Wenjing; Guo, Zhiting; Sun, Xuejing; Xiao, Rong

doi:10.1016/j.biopha.2023.115649

Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.115649

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27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota

Ling Hao,

Lijing Wang,

Mengwei Ju

et al.

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2024

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Cited by 5 publications

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The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

Liang,

Liu,

Cheng

et al. 2024

Alzheimer's & Dementia

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Over the past decades, accumulating evidence suggests that the gut microbiome exerts a key role in Alzheimer's disease (AD). The Alzheimer's Association Workgroup is updating the diagnostic criteria for AD, which changed the profiles and categorization of biomarkers from “AT(N)” to “ATNIVS.” Previously, most of studies focus on the correlation between the gut microbiome and amyloid beta deposition (“A”), the initial AD pathological feature triggering the “downstream” tauopathy and neurodegeneration. However, limited research investigated the interactions between the gut microbiome and other AD pathogenesis (“TNIVS”). In this review, we summarize current findings of the gut microbial characteristics in the whole spectrum of AD. Then, we describe the association of the gut microbiome with updated biomarker categories of AD pathogenesis. In addition, we outline the gut microbiome‐related therapeutic strategies for AD. Finally, we discuss current key issues of the gut microbiome research in the AD field and future research directions.Highlights The new revised criteria for Alzheimer's disease (AD) proposed by the Alzheimer's Association Workgroup have updated the profiles and categorization of biomarkers from “AT(N)” to “ATNIVS.” The associations of the gut microbiome with updated biomarker categories of AD pathogenesis are described. Current findings of the gut microbial characteristics in the whole spectrum of AD are summarized. Therapeutic strategies for AD based on the gut microbiome are proposed.

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The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

Liang,

Liu,

Cheng

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

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18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol

Zhang,

Wang,

Guo

et al. 2024

Experimental Gerontology

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The mechanisms, hallmarks, and therapies for brain aging and age-related dementia

Jin,

Lu,

Zhang

et al. 2024

Science Bulletin

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27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota

Cited by 5 publications

References 78 publications

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol

The mechanisms, hallmarks, and therapies for brain aging and age-related dementia

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