Neutrophil-to-lymphocyte ratio predicting suicide risk in euthymic patients with bipolar disorder: Moderatory effect of family history

Ivković, Maja; Pantović-Stefanović, Maja; Dunjić-Kostić, Bojana; Jurišić, Vladimir; Lačković, Milena; Totić-Poznanović, Sanja; Jovanović, Aleksandar; Damjanović, Aleksandar

doi:10.1016/j.comppsych.2016.01.005

Cited by 68 publications

(45 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies had already shown that the NLR is significantly higher in patients with MDD [14] and bipolar disorder [16] than in healthy controls. In addition, it has recently been suggested that NLR may be useful in predicting risk of SA in the subpopulation of bipolar disorder patients with a family history of SA [18] or in differentiating violent SAs and nonviolent SAs [32]. The only negative study, to the best of our knowledge, regarding an association between NLR and suicidality is the one by Gundogdu Meydaneri and Meydaneri [33].…”

Section: Nlr As a Biological Marker Of Sbmentioning

confidence: 99%

“…Furthermore, meta-analytic evidence has also shown increased NLR in patients with MDD as compared with healthy controls [17]. Two recent studies even suggest that NLR may be a marker for suicide vulnerability in patients with bipolar disorder or MDD [18,19]. NLR was substantially higher in suicidal depressed patients compared with nonsuicidal depressed patients and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior

et al. 2020

View full text Add to dashboard Cite

Background. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have emerged as important peripheral inflammatory biomarkers. Recent data suggest a possible role of the immune system in the pathophysiology of suicidal behavior (SB). The aim of this study is to evaluate the association among NLR, MLR, and PLR and SB in patients with major depressive disorder (MDD), and to test its validity as a biomarker for suicidality. Methods. We evaluated 538 patients with MDD (mean age [standard deviation] = 43.87 [14.36] years; females: 68.8%). A logistic regression model was estimated to determine the independent factors associated with suicide risk in patients with and without a history of suicide attempt (SA). Results. Three hundred ninety-three patients (74.7%) had a personal history of SA. Patients with a previous SA were more frequently female (71.9% vs. 59.6%; p = 0.007), significantly younger (41.20 vs. 51.77 years; p < 0.001), had lower depression severity at enrolment (15.58 vs. 18.42; p < 0.000), and significantly higher mean NLR and PLR ratios (2.27 vs. 1.68, p = 0.001; 127.90 vs. 109.97, p = 0.007, respectively). In the final logistic regression model, after controlling for age, sex, and depression severity, NLR was significantly associated with SB (β = 0.489, p = 0.000; odds ratio [95% confidence intervals] = 1.631 [1.266–2.102]). We propose a cut-off value of NLR = 1.30 (sensitivity = 75% and specificity = 35%). Conclusions. Our data suggest that NLR may be a valuable, reproducible, easily accessible, and cost-effective strategy to determine suicide risk in MDD.

show abstract

Section: Nlr As a Biological Marker Of Sbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As such, raised NLRs and PLRs have also been shown to be associated with increased cytokine production and oxidative stress and have been used to measure the systemic inflammatory response. Furthermore, an increased NLR and dysfunctional platelets have also been linked to patients with psychiatric disorders including depression (18,(40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Wei

Zhou

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

Post-stroke depression (PSD) is the most prevalent psychiatric complication of acute ischemic stroke. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are indicators of inflammation and are associated with stroke and depression. Therefore, the purpose of the present study was to examine the relationship between NLR/PLR and PSD. Retrospective analysis was carried out in 376 patients with first-ever acute ischemic stroke in the First Affiliated Yijishan Hospital of Wannan Medical College between March 2015 and September 2017. Patients were divided into PSD (n=104; 27.7%) and non-PSD (n=272; 72.3%) groups according to the Diagnostic and Statistical Manual of Mental Disorders-IV criteria at 6 months after stroke. Clinical data were collected retrospectively. NLR and PLR were acquired retrospectively from the routine blood tests performed at admission. A total of 120 healthy volunteers from the physical examination center in the First Affiliated Yijishan Hospital of Wannan Medical College were recruited as controls. Using logistic regression analysis, NLR (≥4.02) and PLR (≥203.74) were independently associated with PSD. NLR, odds ratio (OR) 3.926, 95% confidence intervals (CI, 2.365-7.947), P<0.001; PLR, OR 3.853, 95% CI (2.214-6.632), P=0.002. The ability of the combined index [area under the receiver operating characteristic curve, 0.701; 95% CI (0.622-0.780); P<0.001] to diagnose PSD was greater than that of either ratio alone. Higher NLRs and PLRs (≥4th quartile) were associated with PSD with a 5.79-fold (P<0.001) increase compared with lower levels of both. Higher NLRs and PLRs were found to be associated with depression 6 months after stroke, and the combined index was more meaningful than either alone in the early clinical detection of PSD.

show abstract

“…In a study investigating the efficacy of NLR in identifying suicide risk in patients with bipolar disorder, it was reported to be a successful biomarker in predicting patients with positive family history [ 19 ]. We did not investigate the family history in our work.…”

Section: Discussionmentioning

confidence: 99%

Can Neutrophil Lymphocyte Ratio Predict the Likelihood of Suicide in Patients with Major Depression?

Meydaneri¹,

Meydaneri²

2018

Cureus

View full text Add to dashboard Cite

BackgroundNeutrophil lymphocyte rate (NLR), platelet lymphocyte rate (PLR), and systemic immune inflammatory index (SIII) are rates obtained from hemogram parameters, and they are biomarkers used for the diagnoses of many diseases and their severity, and prediction of disease. In addition to the NLR, PLR, and SIII, platelets, plateletcrit (PCT), and platelet distribution width (PDW), which are platelet indices, are also investigated as biomarkers in many diseases. There are limited studies on the use of hemogram derivates (NLR, PLR, and SIII) in the diagnosis and severity determination of psychiatric disorders.ObjectivesIn this study, we aimed to investigate the effect of biomarkers and the proportions of NLR, PLR, and SIII, which are obtained from hemogram parameters, to distinguish or predict the patients with major depression who are likely to commit suicide.Materials and methodsIn this retrospective study, the files of patients referred to an educational research emergency and psychiatric outpatient clinic between June 2017 and December 2017 were evaluated. Patients who had been referred to the emergency polyclinic because of suicide attempts and those with major depression diagnosed at a psychiatric clinic were evaluated in this study. All hemogram evaluations were performed using the Sysmex XT-2000i Automated Hematology Analyzer (GMI, MN, USA).ResultsTwenty-seven suicide patients and 26 major depression groups meeting the study acceptance criteria were included in the evaluation. Of these patients, 40 were female and 13 were male. There was no difference between the groups in terms of age, body mass index, and complete blood count (CBC) parameters such as white blood cell (WBC), neutrophil count, lymphocyte count, eosinophil count, monocyte count, platelet indices, and NLR, PLR, SIII, which were obtained from the hemogram.ConclusionWe found that the neutrophil to lymphocyte ratio and other biomarkers obtained from hemograms were higher in patients with major depression than those who had suicide attempts, but we found that this was not statistically significant.

show abstract

Neutrophil-to-lymphocyte ratio predicting suicide risk in euthymic patients with bipolar disorder: Moderatory effect of family history

Cited by 68 publications

References 50 publications

Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior

Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Can Neutrophil Lymphocyte Ratio Predict the Likelihood of Suicide in Patients with Major Depression?

Contact Info

Product

Resources

About