Effects of yarn types and fabric types on the compliance and bursting strength of vascular grafts

Lou, Ching Wen; Lu, Po; Hu, Jin-Jia; Lin, Jia Horng

doi:10.1016/j.jmbbm.2016.03.002

Cited by 10 publications

(2 citation statements)

References 46 publications

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“…The degree of platelet adhesion of fabric was determined by measuring the quantity of adhered platelets. Activated platelets can not only activate a variety of coagulation factors, but their adhesion to blood contact materials is the key to cause vascular graft coagulation and thrombosis [ 5 ]. Compared with other blood cells, platelets were more sensitive to the contact of biomaterial surfaces.…”

Section: Resultsmentioning

confidence: 99%

“…However, the implants are first exposed to blood after implantation, which will lead to blood compatibility problems [ 3 ]. The existence of implants usually causes considerable side effects—such as coagulation, intimal hyperplasia, infection, and thrombosis—which lead to the failure of implantation [ 4 , 5 , 6 , 7 ]. In previous studies, anticoagulant drugs such as heparin were added to the implants to avoid coagulation reaction.…”

Section: Introductionmentioning

confidence: 99%

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Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

et al. 2022

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Medical apparatus and instruments, such as vascular grafts, are first exposed to blood when they are implanted. Therefore, blood compatibility is considered to be the critical issue when constructing a vascular graft. In this regard, the coating method is verified to be an effective and simple approach to improve the blood compatibility as well as prevent the grafts from blood leakage. In this study, polyester fabric is chosen as the substrate to provide excellent mechanical properties while a coating layer of polyurethane is introduced to prevent the blood leakage. Furthermore, gelatin is coated on the substrate to mimic the native extracellular matrix together with the improvement of biocompatibility. XPS and FTIR analysis are performed for elemental and group analysis to determine the successful coating of polyurethane and gelatin on the polyester fabrics. In terms of blood compatibility, hemolysis and platelet adhesion are measured to investigate the anticoagulation performance. In vitro cell experiments also indicate that endothelial cells show good proliferation and morphology on the polyester fabric modified with such coating layers. Taken together, such polyester fabric coated with polyurethane and gelatin layers would have a promising potential in constructing vascular grafts with expected blood compatibility and biocompatibility without destroying the basic mechanical requirements for vascular applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

et al. 2022

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Development of a Silk Fibroin‐Small Intestinal Submucosa Small‐Diameter Vascular Graft with Sequential VEGF and TGF‐β1 Inhibitor Delivery for In Situ Tissue Engineering

Liu

Rütten

Buhl

et al. 2023

Macromolecular Bioscience

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Proper endothelialization and limited collagen deposition on the luminal surface after graft implantation plays a crucial role to prevent the occurrence of stenosis. To achieve these conditions, a biodegradable graft with adequate mechanical properties and the ability to sequentially deliver therapeutic agents isfabricated. In this study, a dual‐release system is constructed through coaxial electrospinning by incorporating recombinant human vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF‐β1) inhibitor into silk fibroin (SF) nanofibers to form a bioactive membrane. The functionalized SF membrane as the inner layer of the graft is characterized by the release profile, cell proliferation and protein expression. It presents excellent biocompatibility and biodegradation, facilitating cell attachment, proliferation, and infiltration. The core‐shell structure enables rapid VEGF release within 10 days and sustained plasmid delivery for 21 days. A 2.0‐mm‐diameter vascular graft is fabricated by integrating the SF membrane with decellularized porcine small intestinal submucosa (SIS), aiming to facilitate the integration process under a stable extracellular matrix structure. The bioengineered graft is functionalized with the sequential administration of VEGF and TGF‐β1, and with the reinforced and compatible mechanical properties, thereby offers an orchestrated solution for stenosis with potential for in situ vascular tissue engineering applications.

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Recent Advances in the Fabrication and Performance Optimization of Polyvinyl Alcohol Based Vascular Grafts

Liu,

Gao,

et al. 2024

Macromolecular Bioscience

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Cardiovascular disease is one of the diseases with the highest morbidity and mortality rates worldwide, and coronary artery bypass grafting is a fast and effective treatment. More researchers are investigating in artificial blood vessels due to the limitations of autologous blood vessels. Despite the availability of large‐diameter vascular grafts (Ø>6 mm) for clinical use, small‐diameter vascular grafts (Ø<6 mm) have been a challenge for researchers to overcome in recent years. Vascular grafts made of polyvinyl alcohol (PVA) and PVA‐based composites have excellent biocompatibility and mechanical characteristics. In order to gain a clearer and more specific understanding of the progress in PVA vascular graft research, particularly regarding the preparation methods, principles, and functionality of PVA vascular graft, this article discusses the mechanical properties, biocompatibility, blood compatibility, and other properties of PVA vascular graft prepared or enhanced with different blends using various techniques that mimic natural blood vessels. The findings reveal the feasibility and promising potential of PVA or PVA‐based composite materials as vascular grafts.This article is protected by copyright. All rights reserved

show abstract

Effects of yarn types and fabric types on the compliance and bursting strength of vascular grafts

Cited by 10 publications

References 46 publications

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

Development of a Silk Fibroin‐Small Intestinal Submucosa Small‐Diameter Vascular Graft with Sequential VEGF and TGF‐β1 Inhibitor Delivery for In Situ Tissue Engineering

Recent Advances in the Fabrication and Performance Optimization of Polyvinyl Alcohol Based Vascular Grafts

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