Genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1/NF-κB signaling pathway

Yoo, Nina; Lee, Ha‐Reum; Son, Jang-Mi; Kang, Hyun‐Soo; Lee, Hee Gu; Yoon, Suk Ran; Yoon, Sun Young; Kim, Jae Wha

doi:10.1016/j.imlet.2016.03.006

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…Given the important role of PKD in bone homeostasis, it is conceivable that PKD may play an important role in bone metastasis of malignant tumors [110]. PKD has been shown to be involved in innate immunity in many different ways, such as: 1) functional regulator of T and B lymphocyte [14], 2) regulator of class IIa HDACs in lymphocytes [111–113], 3) modulator of β1 integrin activity in T lymphocytes [114], 4) regulator of IL-2 via TCR stimulation [115], 5) downstream target in Toll-like receptor 9 (TLR9) signaling in macrophages [116] and TLR2 in mouse bone marrow-derived mast cells [117], 7) promoter of cell proliferation in chronic myelogenous leukemia (CML) [118] and 8) regulator of neutrophil chemotaxis [119]. …”

Section: Pkd Regulates Major Biological Processes That Contribute mentioning

confidence: 99%

Protein kinase D signaling in cancer: A friend or foe?

Roy

Deng

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction pathways mediated by PKD can be triggered by a variety of stimuli including G protein-coupled receptor agonists, growth factors, hormones, and cellular stresses. The regulatory mechanisms and physiological roles of PKD have been well documented including cell proliferation, survival, migration, angiogenesis, regulation of gene expression, and protein/membrane trafficking. However, its precise roles in disease progression, especially in cancer, remain elusive. A plethora of studies documented the cell- and tissue-specific expressions and functions of PKD in various cancer-associated biological processes, while the causes of the differential effects of PKD have not been thoroughly investigated. In this review, we have discussed the structural-functional properties, activation mechanisms, signaling pathways and physiological functions of PKD in the context of human cancer. Additionally, we have provided a comprehensive review of the reported tumor promoting or tumor suppressive functions of PKD in several major cancers types and discussed the discrepancies that have been raised on PKD as a major regulator of malignant transformation.

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Section: Pkd Regulates Major Biological Processes That Contribute mentioning

confidence: 99%

Protein kinase D signaling in cancer: A friend or foe?

Roy

Deng

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…(Thymelaeaceae) is an oriental herb widely distributed throughout China. Genkwa Flos, the dried flower buds of DG, is commonly used in TCM as an antitussive, expectorant, diuretic [ 7 ], antitumor [ 8 , 9 ], antileukemic [ 10 ], and anti-inflammatory [ 11 , 12 ] medicine. Crude herbs of DG (CHDG) are often used as an external medicine to treat scabies baldness, carbuncles, and chilblain owing to their significant purgation and curative effects.…”

Section: Introductionmentioning

confidence: 99%

Identification of Daphne genkwa and Its Vinegar-Processed Products by Ultraperformance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry and Chemometrics

Zhang

Yao

et al. 2023

Molecules

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Crude herbs of Daphne genkwa (CHDG) are often used in traditional Chinese medicine to treat scabies baldness, carbuncles, and chilblain owing to their significant purgation and curative effects. The most common technique for processing DG involves the use of vinegar to reduce the toxicity of CHDG and enhance its clinical efficacy. Vinegar-processed DG (VPDG) is used as an internal medicine to treat chest and abdominal water accumulation, phlegm accumulation, asthma, and constipation, among other diseases. In this study, the changes in the chemical composition of CHDG after vinegar processing and the inner components of the changed curative effects were elucidated using optimized ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Untargeted metabolomics, based on multivariate statistical analyses, was also used to profile differences between CHDG and VPDG. Eight marker compounds were identified using orthogonal partial least-squares discrimination analysis, which indicated significant differences between CHDG and VPDG. The concentrations of apigenin-7-O-β-d-methylglucuronate and hydroxygenkwanin were considerably higher in VPDG than those in CHDG, whereas the amounts of caffeic acid, quercetin, tiliroside, naringenin, genkwanines O, and orthobenzoate 2 were significantly lower. The obtained results can indicate the transformation mechanisms of certain changed compounds. To the best of our knowledge, this study is the first to employ mass spectrometry to detect the marker components of CHDG and VPDG.

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