Halo and pseudo-halo melanoma

Suzuki, Nathalie Mie; Dalapicola, Monique Coelho; Argenziano, Giuseppe; Lallas, Aimilios; Longo, Caterina; Piana, Simonetta; Ferrara, Gerardo; Raucci, Margherita; Moscarella, Elvira

doi:10.1016/j.jaad.2015.09.027

Cited by 8 publications

(7 citation statements)

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“…Irregular hyperpigmented areas usually correlate with clumps of melanin or hyperpigmented atypical melanocytes in the epidermis or stratum corneum. Angulated lines are similar to the rhomboidal structures of LM (see below) [66]. Atypical dots/globules and irregular hyperpigmented areas (Figure 3) are also the most prevalent dermatoscopic features in small diameter melanoma (<5 mm) [67].…”

Section: Early Superficial Spreading Melanomamentioning

confidence: 59%

“…Histologically, early regression features show moderate to dense lichenoid infiltrate in the upper dermis; in fully developed regression, lymphocytes have been replaced by melanophages and fibrosis. Early regression may be rarely seen on dermoscopy as an asymmetric irregular homogeneous pigmentation with asymmetric vitiligoid halo (so-called "halo nevus-like melanoma") [66]. Granularity/peppering (dots, blue-gray) and scar-like depigmentation (structureless zone, white) are the dermoscopic features of fully developed histological regression [6,7,9,26].…”

Section: Early Superficial Spreading Melanomamentioning

confidence: 99%

“…Lallas et al recently proved that atypical pigment network, irregularly pigmented areas, regression, prominent skin marking, and angulated lines are the five main positive dermoscopic indicators of melanoma in situ [66]. Irregular hyperpigmented areas usually correlate with clumps of melanin or hyperpigmented atypical melanocytes in the epidermis or stratum corneum.…”

Section: Early Superficial Spreading Melanomamentioning

confidence: 99%

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Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

Massone

Hofman-Wellenhof

Chiodi

et al. 2021

Genes

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Dermoscopy is a non-invasive, in vivo technique that allows the visualization of subsurface skin structures in the epidermis, at the dermoepidermal junction, and in the upper dermis. Dermoscopy brought a new dimension in evaluating melanocytic skin neoplasms (MSN) also representing a link between clinical and pathologic examination of any MSN. However, histopathology remains the gold standard in diagnosing MSN. Dermoscopic–pathologic correlation enhances the level of quality of MSN diagnosis and increases the level of confidence of pathologists. Melanoma is one of the most genetically predisposed among all cancers in humans. The genetic landscape of melanoma has been described in the last years but is still a field in continuous evolution. Melanoma genetic markers play a role not only in melanoma susceptibility, initiation, and progression but also in prognosis and therapeutic decisions. Several studies described the dermoscopic specific criteria and predictors for melanoma and their histopathologic correlates, but only a few studies investigated the correlation among dermoscopy, pathology, and genetic of MSN. The aim of this work is to review the published data about dermoscopic features of melanoma, their histopathological correlates with regards also to genetic alterations. Particularly, this review will focus on low-CSD (cumulative sun damage) melanoma or superficial spreading melanoma, high-CSD melanoma, and nevus-associated melanoma.

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Section: Early Superficial Spreading Melanomamentioning

confidence: 59%

Section: Early Superficial Spreading Melanomamentioning

confidence: 99%

Section: Early Superficial Spreading Melanomamentioning

confidence: 99%

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Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

Massone

Hofman-Wellenhof

Chiodi

et al. 2021

Genes

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“…Clinical evaluation shows depigmentation surrounding the nevus, which is often the first visible and disturbing feature. 6 The majority of patients with halo nevi have the 2nd or 3rd Fitzpatrick skin type. Dermoscopy of halo nevi reveals their typical characteristics: a whitish halo rim encircling a melanocytic lesion and lack of globules or macules of pigment.…”

Section: Discussionmentioning

confidence: 99%

In vivo reflectance confocal microscopy of halo nevi

Pogorzelska-Antkowiak¹,

Corneli

Agozzino

2021

Skin Research and Technology

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Halo nevi named also Sutton's nevi are benign melanocytic lesions occurring especially among adolescents. Halo nevus was first described in the 16th century as a benign, rapidly changing melanocytic lesion with a whitish halo around preexisting nevus. In 1916, Sutton used the term "leukoderma acquisitum centrifugum" for the first time. The incidence of halo nevi in the entire population is about 1%, with no predilection for gender or race. 1 The majority of patients have multiple halo lesions, which are usually located on the back.Clinical examination often shows a disturbing white ring surrounding the nevus. Some authors indicate a familial tendency for halo nevi, or coexistence with atopic dermatitis and autoimmune disorders.Clinically, halo nevi are important "melanoma simulators," which usually appear in children and young adults. Besides, halo phenomenon can arise in atypical nevi, in nonmelanocytic tumors, inflammatory lesions, but also in melanoma. Whitish halo surrounding nevi can be clinically and dermoscopically difficult to distinguish from regression in melanoma. 2,3 It could be notably challenging when "halo" is slightly visible or asymmetric. Reflectance confocal microscopy in

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“…6a). In reflectance confocal microscopy, compound nevi can sometimes reveal features typical for congenital nevi, but occasionally local disarray can be observed 28–31 …”

Section: Aim Of the Studymentioning

confidence: 99%

Mimics of melanoma in reflectance confocal microscopy

Pogorzelska-Antkowiak¹,

Calik²

2020

Int J Dermatology

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The diagnosis of melanoma is challenging for both dermatologists and oncologists. Incidence of melanoma increases at a rate of 3–7% per year. Usage of modern tools such as dermoscopy and in vivo reflectance confocal microscopy improve early diagnosis and can save a life. There are a few melanoma simulators which can cause confusion and mislead in the differential diagnosis. This study aims to present skin lesions which can be similar to melanoma in confocal microscopy and to emphasize the importance of a detailed differential diagnosis. We describe five melanocytic lesions similar to melanoma and misleading confocal features. Although in vivo reflectance confocal microscopy is very useful in differentiating melanocytic lesions, histopathology evaluation in cases of melanoma mimics is definitive.

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Halo and pseudo-halo melanoma

Cited by 8 publications

References 0 publications

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

In vivo reflectance confocal microscopy of halo nevi

Mimics of melanoma in reflectance confocal microscopy

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