Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China

Abstract

The aim of this study was to understand the epidemiology, serotype, antibiotic sensitivity, and clonal structure of Erysipelothrix rhusiopathiae strains in China. Forty-eight strains were collected from seven provinces during the period from 2012 to 2013. Pulse-field electrophoresis identified 32 different patterns which were classified into clonal groups A–D. Most pulsed-field gel electrophoresis (PFGE) patterns were observed in clonal complex A and B, suggesting high diversity of genetic characterization in these two predominant clonal complexes. Antibiotic sensitivity test shows that all the stains were susceptible to ampicillin, erythromycin, and cefotaxime, and resistant to kanamycin, cefazolin, sulfadiazine, and amikacin. Erythromycin and ampicillin are recommended as first-line antibiotics for treatment of E. rhusiopathiae in China. The high variation in PFGE pattern among the main clonal groups shows that the E. rhusiopathiae in China may originate from different lineages and sources instead of from expansion of a single clonal lineage across different regions.

flrA,flrBandflrCregulate adhesion by controlling the expression of critical virulence genes inVibrio alginolyticus

“… 38 Several adhesion-related genes have been identified in V. alginolyticus , 3 Pseudomonas putida , 39 P. aeruginosa , 39 Candida albicans , 40 E. coli 41 and Erysipelothrix rhusiopathiae . 42 However, more details about the mechanism have not been found.…”

Fisetin Lowers Streptococcus suis serotype 2 Pathogenicity in Mice by Inhibiting the Hemolytic Activity of Suilysin

“…The sensitivity of SC19 to fisetin was measured as previously described with minor modifications ( Ding et al, 2015 ). The minimal inhibitory concentration (MIC) of fisetin against SC19 was determined by a serial dilution method, according to the procedures of the CLSI guideline M31-A2.…”

Aortic Valve Endocarditis with Erysipelothrix rhusiopathiae: A Rare Zoonosis

“…E. rhusiopathiae can cause disease in pigs and poultry although it has been assessed that a large proportion of the animals are asymptomatic carriers. 4 , 5 The clinical manifestations of disease in pigs are the same as in humans. 4 , 5 E. rhusiopathiae also cause severe infections in turkeys and is an emerging problem in hen-farming.…”

“… 4 , 5 The clinical manifestations of disease in pigs are the same as in humans. 4 , 5 E. rhusiopathiae also cause severe infections in turkeys and is an emerging problem in hen-farming. 4 Vaccines have been developed for pigs and sheep, but not for poultry.…”