Travelers’ Diarrhea in Children at Risk

Soriano‐Arandes, Antoni; García-Carrasco, Emely; Serre-Delcor, Núria; Treviño-Maruri, Begoña; Sulleiro, Elena; Ruiz-Giardín, José Manuel; Sanmartín, Juan Víctor; Torrús‐Tendero, Diego; Marcos, Guillermo; Cuadros, Juan; Martín-Echevarría, Esteban; López‐Vélez, Rogelio; Molina, Israel; Pérez‐Molina, José A.

doi:10.1097/inf.0000000000001049

Cited by 16 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, there appears to be a window of time early in childhood development when Giardia infection is negatively associated with diarrhea. Studies of several pediatric cohorts show either no correlation or a negative correlation between Giardia infection and diarrhea ( 30 , 51 , 53 – 55 , 73 ), although definitions of diarrhea vary from “loose stool” to clinically severe diarrhea. Notably, those studies that specify moderate to severe diarrhea show a significant association between Giardia infection and not having diarrhea ( 30 , 54 ), suggesting that Giardia infection may be negatively associated with severe diarrhea but not loose stools.…”

Section: Discussionmentioning

confidence: 99%

Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome

Berry

Johnson

Martins

et al. 2020

mSphere

View full text Add to dashboard Cite

Enteric parasitic infections are among the most prevalent infections in lower- and middle-income countries (LMICs) and have a profound impact on global public health. While the microbiome is increasingly recognized as a key determinant of gut health and human development, the impact of naturally acquired parasite infections on microbial community structure in the gut, and the extent to which parasite-induced changes in the microbiome may contribute to gastrointestinal symptoms, is poorly understood. Enteric parasites are routinely identified in companion animals in the United States, presenting a unique opportunity to leverage this animal model to investigate the impact of naturally acquired parasite infections on the microbiome. Clinical, parasitological, and microbiome profiling of a cohort of 258 dogs revealed a significant correlation between parasite infection and composition of the bacterial community in the gut. Relative to other enteric parasites, Giardia was associated with a more pronounced perturbation of the microbiome. To compare our findings to large-scale epidemiological studies of enteric diseases in humans, a database mining approach was employed to integrate clinical and microbiome data. Substantial and consistent alterations to microbiome structure were observed in Giardia-infected children. Importantly, infection was associated with a reduction in the relative abundance of potential pathobionts, including Gammaproteobacteria, and an increase in Prevotella—a profile often associated with gut health. Taken together, these data show that widespread Giardia infection in young animals and humans is associated with significant remodeling of the gut microbiome and provide a possible explanation for the high prevalence of asymptomatic Giardia infections observed across host species. IMPORTANCE While enteric parasitic infections are among the most important infections in lower- and middle-income countries, their impact on gut microbiota is poorly understood. We reasoned that clinical symptoms associated with these infections may be influenced by alterations of the microbiome that occur during infection. To explore this notion, we took a two-pronged approach. First, we studied a cohort of dogs naturally infected with various enteric parasites and found a strong association between parasite infection and altered gut microbiota composition. Giardia, one of the most prevalent parasite infections globally, had a particularly large impact on the microbiome. Second, we took a database-driven strategy to integrate microbiome data with clinical data from large human field studies and found that Giardia infection is also associated with marked alteration of the gut microbiome of children, suggesting a possible explanation for why Giardia has been reported to be associated with protection from moderate to severe diarrhea.

show abstract

Section: Discussionmentioning

confidence: 99%

Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome

Berry

Johnson

Martins

et al. 2020

mSphere

View full text Add to dashboard Cite

show abstract

“…O período de manifestação pode ser de dois a três dias, com desconforto ou impedimento para a realização de atividades, podendo evoluir para quadro de desidratação, principalmente em grupos vulneráveis como crianças, idosos e portadores de doenças crônicas, resultando também na diminuição da duração da viagem [61][62][63][64] .…”

Section: Segurança Sanitária Na Produção E Consumo De Moluscosunclassified

Impactos da promoção de alimentos tradicionais como produto turístico gastronômico: estudo da cadeia produtiva da matéria-prima

Duprat¹

View full text Add to dashboard Cite

show abstract

Travel‐related gastrointestinal diseases: Assessment and management

Butler

McLoughlin

Flaherty

2022

Public Health Challenges

View full text Add to dashboard Cite

Introduction: Gastrointestinal illnesses are among the most common health problems affecting travellers returning from international travel. Its public health implications include economic healthcare costs and the risk of promoting antimicrobial resistance. This narrative review aims to critically appraise the literature concerning gastrointestinal diseases in travellers and outlines a practical approach to aid clinicians in their assessment and management. Methods: The Medline (PubMed) and SCOPUS databases were searched for articles relating to gastrointestinal issues in returning travellers. Articles were primarily restricted to those published in the last 5 years. Only studies on human subjects were included. Results: Diarrhoea is the most common gastrointestinal symptom experienced by approximately 40%-60% of travellers, but abdominal pain, bloating and fatigue are also common. Diarrhoeagenic Escherichia coli species remain the most common cause of travellers' diarrhoea (TD), with parasitic diseases predominating in those with persistent symptoms. Molecular diagnostic techniques enable highly sensitive simultaneous testing for a multitude of enteropathogens, though more research is required to confirm the pathogenic significance of organisms identified. Further research into poorly absorbable antibiotics and novel therapies such as phage treatment may help to alleviate the burden of antimicrobial resistance. There is a role for empirical anti-parasitic therapy in selected cases. Conclusion: Clinicians across a range of medical specialities should be familiar with the presentation, aetiology and management of gastrointestinal illness in the returning traveller. Efforts to improve destination sanitation and hygiene infrastructure may serve to reduce the burden of preventable illness in this setting.

show abstract

Travelers’ Diarrhea in Children at Risk

Cited by 16 publications

References 22 publications

Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome

Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome

Impactos da promoção de alimentos tradicionais como produto turístico gastronômico: estudo da cadeia produtiva da matéria-prima

Travel‐related gastrointestinal diseases: Assessment and management

Contact Info

Product

Resources

About