Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus)

Zhang, Jiliang; Sun, Peng; Yang, Fan; Kong, Tao; Zhang, Ruichen

doi:10.1016/j.chemosphere.2016.02.127

Cited by 44 publications

(15 citation statements)

References 49 publications

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“…TBT has been shown to act as an obesogen in multiple organisms including mice (30–32, 50–52) rats (53), goldfish (54), and zebrafish (55) which supports the hypothesis that obesogens are largely not species specific. However, although there are several in vitro models available to study the molecular underpinnings of obesogen exposure, the mechanisms through which obesogens contribute to obesity in animal models are likely to be more complex than those described for cell cultures.…”

Section: In Vivo Approachesmentioning

confidence: 68%

Current Research Approaches and Challenges in the Obesogen Field

Chamorro-García

Blumberg

2019

Front. Endocrinol.

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Obesity is a worldwide pandemic that also contributes to the increased incidence of other diseases such as type 2 diabetes. Increased obesity is generally ascribed to positive energy balance. However, recent findings suggest that exposure to endocrine-disrupting chemicals such as obesogens during critical windows of development, may play an important role in the current obesity trends. Several experimental approaches, from in vitro cell cultures to transgenerational in vivo studies, are used to better understand the mechanisms of action of obesogens, each of which contributes to answer different questions. In this review, we discuss current knowledge in the obesogen field and the existing tools developed in research laboratories using tributyltin as a model obesogen. By understanding the advantages and limitations of each of these tools, we will better focus and design experimental approaches that will help expanding the obesogen field with the objective of finding potential therapeutic targets in human populations.

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Section: In Vivo Approachesmentioning

confidence: 68%

Current Research Approaches and Challenges in the Obesogen Field

Chamorro-García

Blumberg

2019

Front. Endocrinol.

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“…Several species (Oncorhynchus tshawytscha, Danio rerio, Carassius auratus and Sebastiscus marmoratus) when exposed to TBT through water (1 ng/L-16.5 μg/L) or diet (0.4-150 ng/g/fish/day) exhibit an increase in lipid and/or TAG content, adiposity (adipocyte size) and/or altered body weight. The alterations reported were observed in short-term (16.5 ng/L-16.5 μg/L for 1 day) and chronic experiments (1 ng/L-135 ng/L during 48 days −9 months) (Lyssimachou et al, 2015;Meador et al, 2011;Ouadah-Boussouf and Babin, 2016;Riu et al, 2014;Tingaud-Sequeira et al, 2011;Zhang et al, 2016;Zhang et al, 2012;Zhang et al, 2013). The effects in the expression pattern of several genes involved in the lipid metabolism, in particular the alterations observed in the nuclear receptors pparγ and rxr and their downstream pathways is in line with the hypothesis that TBT alter the lipid metabolism through the interaction with the heterodimer PPARγ/ RXR (Lyssimachou et al, 2015;Zhang et al, 2009;Dimastrogiovanni et al, 2015;Li et al, 2014).…”

Section: Organotinsmentioning

confidence: 88%

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

Capitão

Lyssimachou

Castro

et al. 2017

Environment International

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The rise of obesity in humans is a major health concern of our times, affecting an increasing proportion of the population worldwide. It is now evident that this phenomenon is not only associated with the lack of exercise and a balanced diet, but also due to environmental factors, such as exposure to environmental chemicals that interfere with lipid homeostasis. These chemicals, also known as obesogens, are present in a wide range of products of our daily life, such as cosmetics, paints, plastics, food cans and pesticide-treated food, among others. A growing body of evidences indicates that their action is not limited to mammals. Obesogens also end up in the aquatic environment, potentially affecting its ecosystems. In fact, reports show that some environmental chemicals are able to alter lipid homeostasis, impacting weight, lipid profile, signaling pathways and/or protein activity, of several taxa of aquatic animals. Such perturbations may give rise to physiological disorders and disease. Although largely unexplored from a comparative perspective, the key molecular components implicated in lipid homeostasis have likely appeared early in animal evolution. Therefore, it is not surprising that the obesogen effects are found in other animal groups beyond mammals. Collectively, data indicates that suspected obesogens impact lipid metabolism across phyla that have diverged over 600 million years ago. Thus, a consistent link between environmental chemical exposure and the obesity epidemic has emerged. This review aims to summarize the available information on the effects of putative obesogens in aquatic organisms, considering the similarities and differences of lipid homeostasis pathways among metazoans, thus contributing to a better understanding of the etiology of obesity in human populations. Finally, we identify the knowledge gaps in this field and we set future research priorities.

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“…Fasting induces increases in brain apelin mRNA expression in Ya-fish (Lin et al, 2014a) and red-bellied piranha (Volkoff, 2014a). Moreover, in goldfish, the obesogen factor tributyltin (TBT) stimulates food intake and also increases brain apelin expression (Zhang et al, 2016b). In cavefish, IP injections of apelin increase orexin brain expression, and CCK injections induce a decrease in brain apelin expression (Penney and Volkoff, 2014), an indication that apelin interacts with other appetite regulators.…”

Section: Hormones Involved In Food Intakementioning

confidence: 99%

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

2016

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Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

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Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus)

Cited by 44 publications

References 49 publications

Current Research Approaches and Challenges in the Obesogen Field

Current Research Approaches and Challenges in the Obesogen Field

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

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