Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus

El-Shereef, Rawhya R.; Lotfi, Ahmed; Abdel-Naeam, Emad A.; Tawfik, Heba Mohamed

doi:10.4137/cmamd.s32269

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…However, an increase was not observed in cSLE patients compared controls. Our results corroborate the association of IL-6 with nephritis reported in some studies [ [30] , [31] , [32] , [33] ]. In addition, an anatomopathological study demonstrated increased IL-6 expression along glomeruli and tubules in the kidneys of patients with lupus nephritis, suggesting that IL-6 may be a biomarker for lupus nephritis [ 34 ].…”

Section: Discussionsupporting

confidence: 93%

Longitudinal comparison of IL-6, IL-10, and IL-12 cytokine profiles in adult and childhood-onset systemic lupus erythematosus

Peliçari

Postal

Sinicato

et al. 2022

Journal of Translational Autoimmunity

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Section: Discussionsupporting

confidence: 93%

Longitudinal comparison of IL-6, IL-10, and IL-12 cytokine profiles in adult and childhood-onset systemic lupus erythematosus

Peliçari

Postal

Sinicato

et al. 2022

Journal of Translational Autoimmunity

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“…Therefore, it will be more clinically helpful to evaluate the correlation between IL-6 and specific manifestations such as nephritis and central nervous system involvement. Although a few studies suggested that serum IL-6 might be associated with nephritis ( 56 ) and central nervous system involvement ( 57 ), it is hard to perform the relevant pooled analyses due to the lack of sufficient data in the included studies. Fourth, previous studies showed that corticosteroid therapy could effectively inhibit IL-6 production in SLE ( 58 , 59 ), suggesting that the difference in immune-suppressor therapy may overestimate or underestimate the correlation between IL-6 and SLE.…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis

Ding¹,

Su²,

You³

et al. 2020

Clinics

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Interleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlation between the serum IL-6 levels and SLE activity. The PubMed and EMBASE databases were thoroughly searched for relevant studies up to September 2019. Standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to describe the differences between serum IL-6 levels in SLE patients and healthy controls and between those in active SLE patients and inactive SLE patients. The correlation between the serum IL-6 levels and disease activity was evaluated using Fisher's z values. A total of 24 studies involving 1817 SLE patients and 874 healthy controls were included in this meta-analysis. Serum IL-6 levels were significantly higher in SLE patients than in the healthy controls (pooled SMD: 2.12, 95% CI: 1.21-3.03, Active SLE patients had higher serum IL-6 levels than inactive SLE patients (pooled SMD: 2.12, 95% CI: 1.21-3.03). Furthermore, the pooled Fisher's z values (pooled Fisher's z=0.36, 95% CI: 0.26-0.46, po0.01) showed that there was a positive correlation between the serum IL-6 levels and SLE activity. This study suggested that serum IL-6 levels were higher in patients with SLE than in healthy controls, and they were positively correlated with disease activity when Systemic Lupus Erythematosus Disease Activity Index44 was defined as active SLE. More homogeneous studies with large sample sizes are warranted to confirm our findings due to several limitations in our meta-analysis.

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“…Organ-specific disease activity was determined by the presence of one or more positive scores in components of the SLEDAI-2K that pertain to different organ domains, as previously described ( 41 ). Renal SLEDAI-2K was defined using scores in the proteinuria, hematuria, pyuria, or urinary casts SLEDAI-2K descriptors ( 41 , 44 ). Persistently active disease was defined as SLEDAI-K score > 4 at both baseline and follow-up visit.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Serum Interleukin (IL)-1β and IL-18 in Systemic Lupus Erythematosus

et al. 2018

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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by biological and clinical heterogeneity. The interleukin (IL)-1 superfamily is a group of innate cytokines that contribute to pathogenesis in many autoimmune diseases. IL-1β and IL-18 are two members that have been shown to play a role in murine lupus-like models, but their role in human SLE remains poorly understood. Here, IL-1β and IL-18 were quantified by enzyme-linked immunosorbent assay in the serum of healthy controls (HCs) and SLE patients from a prospectively followed cohort. Disease activity and organ damage were assessed using SLE disease activity index 2000 (SLEDAI-2K) and SLE damage index scores (SDI), respectively. 184 SLE patients (mean age 44.9 years, 91% female, 56% double-stranded deoxyribonucleic acid positive) were compared to 52 HC. SLE patients had median [IQR] SLEDAI-2K of 4 [2,6], and SDI of 1 [0–2]. Serum IL-18 levels were statistically significantly higher in SLE patients compared to HCs. Univariable linear regression analyses showed that patients with active renal disease or irreversible organ damage had statistically significantly elevated serum IL-18 levels. The association between serum IL-18 and active renal disease was confirmed in multivariable analysis after adjusting for ethnicity and organ damage. High baseline serum IL-18 levels were associated with organ damage at the subsequent visit. Serum IL-1β levels were not significantly elevated in SLE patients when compared to HCs and had no association with overall or organ-specific disease activity or organ damage in cross-sectional and longitudinal analyses. Our data suggest that serum IL-18 and IL-1β have different clinical implications in SLE, with IL-18 being potentially associated with active renal disease.

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Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus

Cited by 11 publications

References 20 publications

Longitudinal comparison of IL-6, IL-10, and IL-12 cytokine profiles in adult and childhood-onset systemic lupus erythematosus

Longitudinal comparison of IL-6, IL-10, and IL-12 cytokine profiles in adult and childhood-onset systemic lupus erythematosus

Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis

Analysis of Serum Interleukin (IL)-1β and IL-18 in Systemic Lupus Erythematosus

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