Mitonuclear Epistasis for Development Time and Its Modification by Diet in <i>Drosophila</i>

Mossman, Jim A.; Biancani, Leann M.; Zhu, Chen Tseh; Rand, David M.

doi:10.1534/genetics.116.187286

Cited by 93 publications

(176 citation statements)

References 105 publications

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“…; Mossman et al . ). The presence of such ‘G × G × E interactions’ indicates that the effects of disrupting coadapted mitonuclear genotypes may vary across environments.…”

Section: Mitonuclear Incompatibilities and Species Boundariesmentioning

confidence: 99%

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The on‐again, off‐again relationship between mitochondrial genomes and species boundaries

2017

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The study of reproductive isolation and species barriers frequently focuses on mitochondrial genomes and has produced two alternative and almost diametrically opposed narratives. On one hand, mtDNA may be at the forefront of speciation events, with co-evolved mitonuclear interactions responsible for some of the earliest genetic incompatibilities arising among isolated populations. On the other hand, there are numerous cases of introgression of mtDNA across species boundaries even when nuclear gene flow is restricted. We argue that these seemingly contradictory patterns can result from a single underlying cause. Specifically, the accumulation of deleterious mutations in mtDNA creates a problem with two alternative evolutionary solutions. In some cases, compensatory or epistatic changes in the nuclear genome may ameliorate the effects of mitochondrial mutations, thereby establishing coadapted mitonuclear genotypes within populations and forming the basis of reproductive incompatibilities between populations. Alternatively, populations with high mitochondrial mutation loads may be rescued by replacement with a more fit, foreign mitochondrial haplotype. Coupled with many nonadaptive mechanisms of introgression that can preferentially affect cytoplasmic genomes, this form of adaptive introgression may contribute to the widespread discordance between mitochondrial and nuclear genealogies. Here, we review recent advances related to mitochondrial introgression and mitonuclear incompatibilities, including the potential for cointrogression of mtDNA and interacting nuclear genes. We also address an emerging controversy over the classic assumption that selection on mitochondrial genomes is inefficient and discuss the mechanisms that lead lineages down alternative evolutionary paths in response to mitochondrial mutation accumulation.

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“…; Mossman et al . ). The presence of such ‘G × G × E interactions’ indicates that the effects of disrupting coadapted mitonuclear genotypes may vary across environments.…”

Section: Mitonuclear Incompatibilities and Species Boundariesmentioning

confidence: 99%

“…; Mossman et al . ). These efforts have shown extensive mitonuclear epistasis for many fitness‐related measures that can exhibit diverse interaction patterns (Fig.…”

Section: Mitonuclear Incompatibilities and Species Boundariesmentioning

confidence: 99%

The on‐again, off‐again relationship between mitochondrial genomes and species boundaries

2017

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“…Indeed, interactions between organellar genomes (mitochondria and plastids) and host genotypes appear to often affect host fitness (e.g., refs. [17][18][19][20].…”

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confidence: 99%

Intraspecific genetic variation in hosts affects regulation of obligate heritable symbionts

Chong

Moran

2016

Proc. Natl. Acad. Sci. U.S.A.

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Symbiotic relationships promote biological diversification by unlocking new ecological niches. Over evolutionary time, hosts and symbionts often enter intimate and permanent relationships, which must be maintained and regulated for both lineages to persist. Many insect species harbor obligate, heritable symbiotic bacteria that provision essential nutrients and enable hosts to exploit niches that would otherwise be unavailable. Hosts must regulate symbiont population sizes, but optimal regulation may be affected by the need to respond to the ongoing evolution of symbionts, which experience high levels of genetic drift and potential selection for selfish traits. We address the extent of intraspecific variation in the regulation of a mutually obligate symbiosis, between the pea aphid (Acyrthosiphon pisum) and its maternally transmitted symbiont, Buchnera aphidicola. Using experimental crosses to identify effects of host genotypes, we measured symbiont titer, as the ratio of genomic copy numbers of symbiont and host, as well as developmental time and fecundity of hosts. We find a large (>10-fold) range in symbiont titer among genetically distinct aphid lines harboring the same Buchnera haplotype. Aphid clones also vary in fitness, measured as developmental time and fecundity, and genetically based variation in titer is correlated with host fitness, with higher titers corresponding to lower reproductive rates of hosts. Our work shows that obligate symbiosis is not static but instead is subject to short-term evolutionary dynamics, potentially reflecting coevolutionary interactions between host and symbiont.

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“…A recent report has also indicated that rapamycin can inhibit the inflammatory reaction induced by nuclear factor (NF)-κB activation and neutrophils (2,3). Rapamycin also reportedly exacerbates the severity of acute lung injury induced by endotoxin and causes cell apoptosis (4).…”

Section: Introductionmentioning

confidence: 99%

Effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury

Zhu

Yuan

et al. 2017

Biomedical Reports

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Abstract. Transfusion-related acute lung injury (TRALI) is a serious complication characterized by the acute onset of non-cardiogenic pulmonary edema following transfusion of blood products. It is not known whether rapamycin has an effect on TRALI that is caused by blood transfusion. The aim of the present study was to determine the effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury. Animal models of TRALI and acute pancreatitis-associated lung injury (APALI) were prepared using Sprague-Dawley rats and histopathological examination of lung tissues was used to validate acute lung injury models. Peripheral blood neutrophils were isolated and early stage apoptosis of neutrophils was detected by flow cytometry. The animal models of TRALI and APALI were constructed successfully. Early stage apoptosis of neutrophils increased in the TRALI group and decreased in the APALI group (P<0.05), while the apoptosis rates in rapamycin intervention TRALI and APALI groups were not significantly different compared to the rate in the control group (P>0.05). In conclusion, early stage apoptosis of neutrophils in TRALI was different from that in APALI, and rapamycin had a limited protective effect on TRALI and APALI in Sprague-Dawley rats.

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Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila

Cited by 93 publications

References 105 publications

The on‐again, off‐again relationship between mitochondrial genomes and species boundaries

The on‐again, off‐again relationship between mitochondrial genomes and species boundaries

Intraspecific genetic variation in hosts affects regulation of obligate heritable symbionts

Effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury

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