In vitro and in vivo evaluation of drug-eluting microspheres designed for transarterial chemoembolization therapy

Wang, Yujing; Molin, Daniël; Sevrin, Chantal; Grandfils, Christian; Akker, Nynke M. S. van den; Gagliardi, Mick; Knetsch, Menno L. W.; Delhaas, Tammo; Koole, Leo Lh

doi:10.1016/j.ijpharm.2016.03.002

Cited by 21 publications

(9 citation statements)

References 46 publications

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“…In vitro studies showed favorable sustained release of the drug and significantly decreased tumor growth rates, suggesting that NCTD/LSD-ACMs can effectively embolize liver tumors [120]. Biodegradable DEBs made from poly(D-L-lactic acid) and loaded with cisplatin or sorafenib are degraded by absorption of water, hydrolysis, erosion of the polymer, and bulk degradation [121]. These microspheres have shown high therapeutic efficacy in vitro [121], [122].…”

Section: Drug Eluting Microspheres-drug Eluting Microspheres Especiallymentioning

confidence: 99%

“…Biodegradable DEBs made from poly(D-L-lactic acid) and loaded with cisplatin or sorafenib are degraded by absorption of water, hydrolysis, erosion of the polymer, and bulk degradation [121]. These microspheres have shown high therapeutic efficacy in vitro [121], [122]. Choi et al developed PLGA microspheres loaded with sorafenib for HCC embolization (Figure 3) [123].…”

Section: Drug Eluting Microspheres-drug Eluting Microspheres Especiallymentioning

confidence: 99%

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Emerging embolic agents in endovascular embolization: an overview

Wang

Sheth

et al. 2020

Prog. Biomed. Eng.

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Endovasular embolization treats diseased and malfunctioned vasculature through a minimally invasive approach that significantly benefits patients. Advances in engineering and materials science have contributed to novel generations of embolic materials that addresses challenges existed in clinically used agents. In this review, we discuss the clinically available embolic agents, their formulations and applications. Additionally, we examine materials in development for embolization, and emphasize the challenges during the process of transitioning from basic science to translational applications in this field.

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Section: Drug Eluting Microspheres-drug Eluting Microspheres Especiallymentioning

confidence: 99%

Section: Drug Eluting Microspheres-drug Eluting Microspheres Especiallymentioning

confidence: 99%

Emerging embolic agents in endovascular embolization: an overview

Wang

Sheth

et al. 2020

Prog. Biomed. Eng.

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“…Compared to the single drug-loaded microspheres, release was faster due to the more porous structure and water swelling of the combination drug-eluting microspheres, precluding subsequent degradation-driven release. The drug combination strategy possibly circumvents tumor drug resistance and in addition, synergic effects were reported both in vitro on cell viability and in vivo on tumor growth by the simultaneous release of the two drugs [86]. As for degradability, the three types of microspheres were not degraded after 9 months.…”

Section: Biodegradable Beads For Drug Delivery and In Vitro Drug Releasementioning

confidence: 99%

Drug-eluting embolic microspheres for local drug delivery – State of the art

Fuchs

Durán

Denys

et al. 2017

Journal of Controlled Release

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Embolic microspheres or beads used in transarterial chemoembolization are an established treatment method for hepatocellular carcinoma patients. The occlusion of the tumor-feeding vessels by intra-arterial injection of the beads results in tumor necrosis and shrinkage. In this short review, we describe the utility of using these beads as devices for local drug delivery. We review the latest advances in the development of non-biodegradable and biodegradable drug-eluting beads for transarterial chemoembolization. Their capability to load different drugs, such as chemotherapeutics and anti-angiogenic compounds with different physicochemical properties, like charge and hydrophilicity/hydrophobicity, are discussed. We specifically address controlled and sustained drug release from the microspheres, and the resulting in vivo pharmacokinetics in the plasma vs. drug distribution in the targeted tissue.

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“…While a broad range of polymerizations has been applied for this purpose, there is until today a need for novel tunable materials . For medical use, a biomaterial should ideally be non‐toxic, have favorable thermal and mechanical properties, be able to hold a payload (when used for drug delivery purposes), (bio)degrade under controlled conditions to non‐harmful fragments, and be chemically versatile . Many of these conditions are met by well‐known materials such as poly(lactic acid) or related polymers.…”

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confidence: 99%

“…The results are depicted in Figure . The chosen cell lines, namely porcine skin fibroblasts (PSF) and human umbilical vein endothelial cells (HUVEC), are selected for their structural role in tissue formation and angiogenesis respectively, two important events in tissue generation and engineering . Overall almost 100% cell viability was observed for PSF and minor toxicity for HUVEC up to 10 mg mL −1 and 96 h of exposure time.…”

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confidence: 99%

Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization

Ramakers

D'Incal

Gagliardi

et al. 2018

Macromol. Rapid Commun.

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Functional synthetic polymers are frequently explored for their use in the biomedical field. To fulfill the stringent demands of biodegradability and compatibility, the materials need to be versatile and tunable. Post‐modification is often considered challenging for well‐known degradable materials like poly(lactic acid) because of their chemical inertness. In this work a procedure is proposed to produce densely functionalized polymer particles using oligomeric precursors synthesized via the Morita–Baylis–Hillman reaction. This allows for a variety of post‐modification reactions to serve bio‐conjugation or tuning of the material properties. The particles are subjected to basic media and found to be degradable. Furthermore, cytotoxicity tests confirm good biocompatibility. Finally, as a proof of concept to demonstrate the versatility of the particles, post‐modification reactions are carried out through the formation of imines.

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In vitro and in vivo evaluation of drug-eluting microspheres designed for transarterial chemoembolization therapy

Cited by 21 publications

References 46 publications

Emerging embolic agents in endovascular embolization: an overview

Emerging embolic agents in endovascular embolization: an overview

Drug-eluting embolic microspheres for local drug delivery – State of the art

Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization

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