Correction: Continuous inertial microparticle and blood cell separation in straight channels with local microstructures

Wu, Zhenlong; Chen, Yu; Wang, Moran; Chung, Aram J.

doi:10.1039/c6lc90035f

Cited by 2 publications

(1 citation statement)

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“…With the progress of production technology, some researchers attained particle separation with composite of electrodes-based DEP and irregular obstacles. [21][22][23][24] Yasukawa et al [25] utilized an slanted electrodes to build the uneven electric field, and achieved the continuous separation of white and red blood cells based on negative dielectrophoresis (nDEP). Meanwhile, the low voltage was generally used to generate a non-uninform electric field within electrodes-based DEP, so the Joule heating effect was neglected.…”

Section: Introductionmentioning

confidence: 99%

Effect of Joule heating on the electroosmotic microvortex and dielectrophoretic particle separation controlled by local electric field*

Yan¹,

Chen²,

Xiong³

et al. 2021

Chinese Phys. B

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Dielectrophoresis (DEP) technology has become important application of microfluidic technology to manipulate particles. By using a local modulating electric field to control the combination of electroosmotic microvortices and DEP, our group proposed a device using a direct current (DC) electric field to achieve continuous particle separation. In this paper, the influence of the Joule heating effect on the continuous separation of particles is analyzed. Results show that the Joule heating effect is caused by the local electric field, and the Joule heating effect caused by adjusting the modulating voltage is more significant than that by driving voltage. Moreover, a non-uniform temperature distribution exists in the channel due to the Joule heating effect, and the temperature is the highest at the midpoint of the modulating electrodes. The channel flux can be enhanced, and the enhancement of both the channel flux and temperature is more obvious for a stronger Joule heating effect. In addition, the ability of the vortices to trap particles is enhanced since a larger DEP force is exerted on the particles with the Joule heating effect; and the ability of the vortex to capture particles is stronger with a stronger Joule heating effect. The separation efficiency can also be increased because perfect separation is achieved at a higher channel flux. Parameter optimization of the separation device, such as the convective heat transfer coefficient of the channel wall, the length of modulating electrode, and the width of the channel, is performed.

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Section: Introductionmentioning

confidence: 99%

Effect of Joule heating on the electroosmotic microvortex and dielectrophoretic particle separation controlled by local electric field*

Yan¹,

Chen²,

Xiong³

et al. 2021

Chinese Phys. B

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A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma

Xia

Strachan

Gifford

et al. 2016

Sci Rep

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Leukocyte reduction of donated blood products substantially reduces the risk of a number of transfusion-related complications. Current ‘leukoreduction’ filters operate by trapping leukocytes within specialized filtration material, while allowing desired blood components to pass through. However, the continuous release of inflammatory cytokines from the retained leukocytes, as well as the potential for platelet activation and clogging, are significant drawbacks of conventional ‘dead end’ filtration. To address these limitations, here we demonstrate our newly-developed ‘controlled incremental filtration’ (CIF) approach to perform high-throughput microfluidic removal of leukocytes from platelet-rich plasma (PRP) in a continuous flow regime. Leukocytes are separated from platelets within the PRP by progressively syphoning clarified PRP away from the concentrated leukocyte flowstream. Filtrate PRP collected from an optimally-designed CIF device typically showed a ~1000-fold (i.e. 99.9%) reduction in leukocyte concentration, while recovering >80% of the original platelets, at volumetric throughputs of ~1 mL/min. These results suggest that the CIF approach will enable users in many fields to now apply the advantages of microfluidic devices to particle separation, even for applications requiring macroscale flowrates.

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Correction: Continuous inertial microparticle and blood cell separation in straight channels with local microstructures

Abstract: Correction for 'Continuous inertial microparticle and blood cell separation in straight channels with local microstructures' by Zhenlong Wu et al., Lab Chip, 2016, 16, 532-542.

Cited by 2 publications

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Effect of Joule heating on the electroosmotic microvortex and dielectrophoretic particle separation controlled by local electric field*

Effect of Joule heating on the electroosmotic microvortex and dielectrophoretic particle separation controlled by local electric field*

A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma

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