Hot Water Epilepsy Successfully Treated With Daily Clobazam

Ekici, Arzu; Özdemır, Özlem; Yimenicioglu, Sevgi; Oren, Ayşe Ceyda; Şen, İsmai̇l

doi:10.1097/pec.0000000000000659

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…16,27 In another study, however, seizures were brought under control with daily clobazam use. 28 Lowering the water temperature and modifying bathing habits were not effective in our cases. We started all our HWE cases on continuous or prophylactic antiepileptic drugs since reflex seizures persisted despite routine precautions.…”

Section: Discussionmentioning

confidence: 61%

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood

et al. 2020

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Hot water epilepsy (HWE) is a subtype of reflex epilepsy in which seizures are triggered by the head being immersed in hot water. Hot water or bathing epilepsy is the type of reflex epilepsy most frequently encountered in our clinic. We describe our patients with HWE and also discuss the clinical features, therapeutic approaches, and prognosis. Eleven patients (10 boys, 1 girl), aged 12 months to 13 years, admitted to the pediatric neurology clinic between January 2018 and August 2019, and diagnosed with HWE or bathing epilepsy based on International League Against Epilepsy (ILAE)-2017, were followed up prospectively for ∼18 months. Patients' clinical and electroencephalography (EEG) findings and treatment details were noted. All 11 patients' seizures were triggered by hot water. Age at first seizure was between 2 months and 12 years. Seizure types were generalized motor seizures, absence, and atonic. EEG was normal in two patients, but nine patients had epileptiform discharges. Magnetic resonance imaging of the brain was performed and reported as normal (except in one case). Histories of prematurity were present in two patients, unprovoked seizures in one, and low birth weight and depressed birth in the other. Patients with HWE have normal neuromuscular development and neurological examination results, together with prophylaxis or seizure control with a single antiepileptic drug, suggesting that it is a self-limited reflex epilepsy.

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Section: Discussionmentioning

confidence: 61%

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood

et al. 2020

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“…We found that early prophylactic treatment with oral benzodiazepines prior to taking the hot water bath successfully prevents the occurrence of these seizures [20]. Many other investigators have also confirmed the therapeutic effectiveness of clobazam [21].…”

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confidence: 51%

Hot-Water Epilepsy and Hyperthermic Kindling- Bridging Laboratory and Clinic

Ullal¹

2015

J Depress Anxiety

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“…Clobazam is a novel option for preventing and seems to be an appropriate choice. [16][17][18] Most reports of HWE are from India and Turkey, suggesting a genetic predisposition. A genetically aberrant thermoregulatory system or an anatomical abnormality of the temporo-insular and parietal networks has been suggested as a possible mechanism for epiloptogenesis.…”

Section: Highlightmentioning

confidence: 99%

Clinical and EEG features, treatment, and outcome of hot water epilepsy in pediatric patients

et al. 2020

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Background: Hot water epilepsy is a type of reflex epilepsy which generally occurs with pouring water on the body during bath. Objective: The aim of this study is to evaluate the clinical and electrophysiological features, treatment, and outcome of the pediatric patients with diagnosis of hot water epilepsy. Methods: Patients were followed and treated at Erciyes University, between January 2010 and January 2016. Results: There were 15 patients total, included 9 (60%) boys and 6 (40%) girls. The average age at diagnosis was 30 months (range: 13-60 months). The follow-up period was 16 months (range: 12-48 months). Seven patients (46.6%) had focal seizures with impaired consciousness, four (26.7%) had focal seizure and four (26.7%) had focal starting and generalized tonic-clonic continuing seizures. Seven patients (46.6%) had abnormal interictal EEG findings, ranged from unilateral slowing of the background activity to bilateral sharp wave. Intermittent clobazam treatment (0.8-1.2 mg/kg) was given to 13 patients (86.7%). Other epileptic treatments were used in 5 (33.3%) patients. Three patients (20.0%) developed nonreflex seizures during followup period. Conclusions: Intermittent clobazam prophylaxis prior to hot water bath, as well as changing bathing habits can be effective in pediatric patients with hot water epilepsy.

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Hot Water Epilepsy Successfully Treated With Daily Clobazam

Cited by 5 publications

References 5 publications

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood

Hot-Water Epilepsy and Hyperthermic Kindling- Bridging Laboratory and Clinic

Clinical and EEG features, treatment, and outcome of hot water epilepsy in pediatric patients

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