The influence of respiratory motion on the cumulative SUV-volume histogram and fractal analyses of intratumoral heterogeneity in PET/CT imaging

Morita, Kenichi; Tsutsui, Yuji; Kidera, Daisuke; Mikasa, Shohei; Maebatake, Akira; Akamatsu, Go; Miwa, Koichi; Baba, Shingo; Sasaki, Masayuki

doi:10.1007/s12149-016-1071-1

Cited by 4 publications

(2 citation statements)

References 20 publications

(32 reference statements)

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“…New parameters were proposed, such as CSH and AUC, in order to provide information about the absolute uptake, the radiotracer distribution, and the lesion dimension [22,33,38,39]. The histograms are similar to DVH used in radiotherapy [30].…”

Section: Discussionmentioning

confidence: 99%

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

et al. 2021

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Gamma Knife treatment is an alternative to traditional brain surgery and whole-brain radiation therapy for treating cancers that are inaccessible via conventional treatments. To assess the effectiveness of Gamma Knife treatments, functional imaging can play a crucial role. The aim of this study is to evaluate new prognostic indices to perform an early assessment of treatment response to therapy using positron emission tomography imaging. The parameters currently used in nuclear medicine assessments can be affected by statistical fluctuation errors and/or cannot provide information on tumor extension and heterogeneity. To overcome these limitations, the Cumulative standardized uptake value (SUV) Histogram (CSH) and Area Under the Curve (AUC) indices were evaluated to obtain additional information on treatment response. For this purpose, the absolute level of [11C]-Methionine (MET) uptake was measured and its heterogeneity distribution within lesions was evaluated by calculating the CSH and AUC indices. CSH and AUC parameters show good agreement with patient outcomes after Gamma Knife treatments. Furthermore, no relevant correlations were found between CSH and AUC indices and those usually used in the nuclear medicine environment. CSH and AUC indices could be a useful tool for assessing patient responses to therapy.

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Section: Discussionmentioning

confidence: 99%

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

et al. 2021

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“…According to the aspiration of radiomics [1–5], not only the presence at a certain location, volume and standardized uptake value (SUV) of a lesion can hold diagnostic value, but also its texture and shape. The apparent texture of a lesion on the reconstructed image is strongly but indefinably affected by noise, partial volume effect (PVE), and reconstruction parameter settings [6–12]. On the other hand, the number of possible parameters to measure textural properties of a lesion are practically unlimited [13], thus the significance of potential candidates needs to be proven in a validation process [9,14].…”

Section: Introductionmentioning

confidence: 99%

Activity painting: PET images of freely defined activity distributions applying a novel phantom technique

Forgács

Kallos-Balogh

Nagy³

et al. 2019

PLoS ONE

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The aim of this work was to develop a novel phantom that supports the construction of highly reproducible phantoms with arbitrary activity distributions for PET imaging. It could offer a methodology for answering questions related to texture measurements in PET imaging. The basic idea is to move a point source on a 3-D trajectory in the field of view, while continuously acquiring data. The reconstruction results in a 3-D activity concentration map according to the pathway of the point source. A 22Na calibration point source was attached to a high precision robotic arm system, where the 3-D movement was software controlled. 3-D activity distributions of a homogeneous cube, a sphere, a spherical shell and a heart shape were simulated. These distributions were used to measure uniformity and to characterize reproducibility. Two potential applications using the lesion simulation method are presented: evaluation in changes of textural properties related to the position in the PET field of view; scanner comparison based on visual and quantitative evaluation of texture features. A lesion with volume of 50x50x50 mm3 can be simulated during approximately 1 hour. The reproducibility of the movement was found to be >99%. The coefficients of variation of the voxels within a simulated homogeneous cube was 2.34%. Based on 5 consecutive and independent measurements of a 36 mm diameter hot sphere, the coefficient of variation of the mean activity concentration was 0.68%. We obtained up to 18% differences within the values of investigated textural indexes, when measuring a lesion in different radial positions of the PET field of view. In comparison of two different human PET scanners the percentage differences between heterogeneity parameters were in the range of 5–55%. After harmonizing the voxel sizes this range reduced to 2–16%. The general activity distributions provided by the two different vendor show high similarity visually. For the demonstration of the flexibility of this method, the same pattern was also simulated on a small animal PET scanner giving similar results, both quantitatively and visually. 3-D motion of a point source in the PET field of view is capable to create an irregular shaped activity distribution with high reproducibility.

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Comparison of image quality between step-and-shoot and continuous bed motion techniques in whole-body 18F-fluorodeoxyglucose positron emission tomography with the same acquisition duration

et al. 2017

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The influence of respiratory motion on the cumulative SUV-volume histogram and fractal analyses of intratumoral heterogeneity in PET/CT imaging

Abstract: Respiratory motion affected the results of the CSH and fractal analyses for the evaluation of the heterogeneity of the PET/CT images. The influence of respiratory motion was considered to vary depending on the object size.

Cited by 4 publications

References 20 publications

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

Activity painting: PET images of freely defined activity distributions applying a novel phantom technique

Comparison of image quality between step-and-shoot and continuous bed motion techniques in whole-body 18F-fluorodeoxyglucose positron emission tomography with the same acquisition duration

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