Comparison of sleep disorders in chronic hepatitis C patients treated with interferon‐based therapy and direct acting antivirals using actigraphy

Nishikawa, Hiroki; Enomoto, Hirayuki; Iwata, Yoshinori; Kishino, Kyohei; Shimono, Yoshihiro; Hasegawa, Kunihiro; Nakano, Chikage; Takata, Ryo; Nishimura, Takashi; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Takashima, Tomoyuki; Ishii, Akio; Iijima, Hiroko; Matsunaga, Hisato; Nakamura, Hitomi; Nishiguchi, Shuhei

doi:10.1111/hepr.12694

Cited by 17 publications

(25 citation statements)

References 31 publications

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“…It is clear from our study that daytime somnolence and sleep disturbances in patients with HCV infection were ameliorated by DAA treatment. A previous report revealed that the PSQI score improved during DAA treatment . Restless leg syndrome also causes sleep disturbances.…”

Section: Discussionmentioning

confidence: 93%

Hepatitis C virus‐related symptoms, but not quality of life, were improved by treatment with direct‐acting antivirals

Ichikawa

Miyaaki

Miuma

et al. 2017

Hepatology Research

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Section: Discussionmentioning

confidence: 93%

Hepatitis C virus‐related symptoms, but not quality of life, were improved by treatment with direct‐acting antivirals

Ichikawa

Miyaaki

Miuma

et al. 2017

Hepatology Research

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“…With regards to the physical activity data, only few studies have availed of actigraphy for capturing activity patterns in HCV‐infected patients . To date, Heeren et al assessed motion drive and intensity of physical activity by actigraphy and detected no differences when comparing patients with hepatitis C to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…With regards to the physical activity data, only few studies have availed of actigraphy for capturing activity patterns in HCV-infected patients. 24,35 To date, Heeren et al 24 assessed motion drive and intensity of physical activity by actigraphy and detected no differences when comparing patients with hepatitis C to healthy controls. One might have expected increases in physical activity to accompany the reduced fatigue in our patients; however, this reduction could have affected other aspects of their lives, since fatigue can manifest in different ways.…”

Section: F I G U R E 3 Severity Of Depression According To Total Bdi-iimentioning

confidence: 99%

Antidepressant effects of direct‐acting antivirals against hepatitis C virus—Results from a pilot study

Hahn

Stokes

Kaiser

et al. 2018

Eur J Clin Investigation

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“…It is the size of a wristwatch, and can be worn without interfering with the normal activity of daily life. [33][34][35][36] DATA COLLECTION A research assistant will collect data elements from patient medical records, including the following at baseline (figure 1):…”

Section: Case Registration Periodmentioning

confidence: 99%

Effect of dexmedetomidine in the prophylactic endoscopic injection sclerotherapy for oesophageal varices: a study protocol for prospective interventional study

Nishikawa

Iwata

Ishii

et al. 2017

BMJ Open Gastroenterol

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BackgroundDexmedetomidine (DEX) is a novel, highly selective α2-adrenoceptor agonist that elicits sedative, amnestic, sympatholytic and analgesic effects in patients. Several Japanese investigators have reported the clinical usefulness of DEX for sedation in endoscopic therapies for gastrointestinal malignancies; however, there have been limited data regarding the usefulness and safety of DEX for sedation during endoscopic procedures for oesophageal varices (OVs), such as endoscopic injection sclerotherapy (EIS). In this prospective, single-arm interventional study, we aimed to elucidate these issues.MethodsPatients who require two or more sessions of prophylactic EIS for the treatment of OVs will be enrolled in this prospective interventional study. EIS procedures include two methods: (1) sedation during endoscopic procedures will be performed using conventional methods (pentazocine (PNZ) and midazolam (MDZ)), and (2) sedation during endoscopic procedures will be performed using PNZ, low-dose MDZ and DEX. These two methods were randomly assigned in the first and second EIS. The effect and safety of these two procedures with respect to patient sedation are to be compared with the degree of sedation evaluated using the Bispectral Index monitoring system (Aspect Medical Systems, Norwood, Massachusetts, USA).Ethics and disseminationThis study received approval from the Institutional Review Board at Hyogo College of Medicine (approval no. 2324). The authors are committed to publishing the study results as widely as possible in peer-reviewed journals, and to ensuring that appropriate recognition is provided to everyone who is working on this study.Trial registration numberUMIN000026688; Pre-results.

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Comparison of sleep disorders in chronic hepatitis C patients treated with interferon‐based therapy and direct acting antivirals using actigraphy

Abstract: Interferon-based triple therapy in patients with CHC may cause significant sleep disturbances. Interferon-free DAA therapy is less likely to deteriorate sleep conditions in patients with CHC.

Cited by 17 publications

References 31 publications

Hepatitis C virus‐related symptoms, but not quality of life, were improved by treatment with direct‐acting antivirals

Hepatitis C virus‐related symptoms, but not quality of life, were improved by treatment with direct‐acting antivirals

Antidepressant effects of direct‐acting antivirals against hepatitis C virus—Results from a pilot study

Effect of dexmedetomidine in the prophylactic endoscopic injection sclerotherapy for oesophageal varices: a study protocol for prospective interventional study

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