Multidisciplinary effort in treating children with hepatoblastoma in China

Abstract

The purpose of this study is to report the first nationwide protocol (Wuhan Protocol) developed by Chinese Children's Cancer Group and the results of multidisciplinary effort in treating hepatoblastoma. In this study, we reported the final analysis, which includes 153 hepatoblastoma patients in 13 hospitals from January 2006 to December 2013. The 6-year overall survival and event-free survival rates were 83.3 ± 3.1% and 71.0 ± 3.7%, respectively, in this cohort. The univariate analysis revealed that female (P = 0.027), under 5 years of age (P = 0.039), complete surgical resection (P = 0.000), no metastases (P = 0.000), and delayed surgery following neoadjuvant chemotherapy (P = 0.000) had better prognosis. In multivariate analysis, male, 5 years of age or above, stage PRETEXT III or IV, and incomplete surgical resection were among the some adverse factors contributing to poor prognosis. The preliminary results from this study showed that patients who underwent treatment following Wuhan Protocol had similar OS and EFS rates compared to those in developed countries. However, the protocol remains to be further optimized in standardizing surgical resection (including liver transplantation), refining risk stratification and risk-based chemotherapy.

Malignant Neoplasms in Children: Clinical Manifestations and Diagnosis

“…Наиболее часто гепатобластома метастазирует в легкие и кости. Регионарные лимфа-тические узлы печени поражаются чрезвычайно редко [17,18].…”

“…Для верификации диагноза необходимо морфологическое исследование ткани первичной опу-холи и/или очагов, подозрительных на метастатические (рис. 17, 18) [17,18].…”

Sphingomyelin synthase 2 overexpression promotes cisplatin‑induced apoptosis of HepG2 cells

“…Hepatoblastoma (HB) is a malignant liver tumor observed in pediatric patients, the incidence of which has increased by 2.18% annually in patients <20 years of age (1). A total of 90% of patients with liver malignancies and <5 years of age were diagnosed with HB (1).…”

“…A total of 90% of patients with liver malignancies and <5 years of age were diagnosed with HB (1). Previously, the main treatment for HB was surgical resection.…”

“…Previously, the main treatment for HB was surgical resection. However, complete tumor resection may only be achieved in a small proportion of patients (1). However, since cisplatin (DDP) was introduced into the treatment regimen, the survival rate had improved markedly (1).…”