Reaction time and rhythm of movement in Huntington's disease

Pueyo, A. Martínez; García‐Ruiz, Pedro J.; Feliz, Cici; Caldentey, Juan García; Val, Javier del; Herranz, Arantxa

doi:10.1016/j.jns.2015.12.037

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Deficits in timing are evident in most motor abnormalities reported in HD: increased reaction time and movement time, as well as prolonged interonset latencies when performing simultaneous and sequential movements are well documented . Our results from the reaction time task indicated longer times in patients with HD than controls (Figure A), in agreement with previous indication of slowness of movement in HD . However, reaction time did not significantly correlate with UHDRS (Figure B).…”

Section: Discussionsupporting

confidence: 88%

“…Overall, our results indicate that interval timing but not reaction time correlates with the severity of the disease, suggesting that conscious time estimation could be a marker of the progression of HD. Both interval timing and reaction time deficits in HD result from neuronal loss in the striatum and disruption of cortico‐striatal circuits . Although slowness of movement was present in our patients according to the reaction time task, we hypothesize that the observed impairments in the PI task in correlation with the UHDRS are not exclusively motor.…”

Section: Discussionmentioning

confidence: 57%

“…Moreover, the reported effects of DA antagonists on interval timing are to produce a rightward shift on Peak location, whereas in this work, we report the opposite in patients with HD. Furthermore, the neuroleptic influence in the experimental motor tasks was reported to be irrelevant at the dose used …”

Section: Discussionmentioning

confidence: 99%

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Deficits in temporal processing correlate with clinical progression in Huntington's disease

et al. 2017

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 57%

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Deficits in temporal processing correlate with clinical progression in Huntington's disease

et al. 2017

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“…Neurophysiological investigations have shown that when HD patients perform finger movements, they have prolonged simple RTs [88][89][90][91] and are also slower than normal [20]. Bradykinesia was also observed during single isometric contractions and during alternating [19,92] and simultaneous or sequential arm movements, which were characterized by less accuracy and longer pauses between movements [6,20,93].…”

Section: Huntington Diseasementioning

confidence: 99%

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Paparella

Fasano

Hallett

et al. 2021

Euro J of Neurology

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Background and purpose Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease. However, clinical and experimental studies indicate that bradykinesia may also be observed in various neurological diseases not primarily characterized by parkinsonism. These conditions include hyperkinetic movement disorders, such as dystonia, chorea, and essential tremor. Bradykinesia may also be observed in patients with neurological conditions that are not seen as "movement disorders," including those characterized by the involvement of the cerebellum and corticospinal system, dementia, multiple sclerosis, and psychiatric disorders. Methods We reviewed clinical reports and experimental studies on bradykinesia in non‐parkinsonian conditions and discussed the major findings. Results Bradykinesia is a common motor abnormality in non‐parkinsonian conditions. From a pathophysiological standpoint, bradykinesia in neurological conditions not primarily characterized by parkinsonism may be explained by brain network dysfunction. Conclusion In addition to the pathophysiological implications, the present paper highlights important terminological issues and the need for a new, more accurate, and more widely used definition of bradykinesia in the context of movement disorders and other neurological conditions.

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“…In brain lesions, neurodegenerative disorders are the most studied, such as Parkinson's and Huntington's diseases (both implying a lesion of the basal ganglia) or Alzheimer's disease. Studies on Parkinson's disease report quasi-consistently that SMT is significantly affected in patients compared to healthy elderly individuals ( Table 4 , N = 5/6), and the study on Huntington's disease reports the same effect (Martínez Pueyo et al, 2016 ). The only study on Alzheimer's disease does not report any difference between patients and healthy elderly individuals (Martin et al, 2017 ).…”

Section: Discussionmentioning

confidence: 94%

Which factors modulate spontaneous motor tempo? A systematic review of the literature

Desbernats,

Martin,

Tallet

2023

Front. Psychol.

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Intentionally or not, humans produce rhythmic behaviors (e.g., walking, speaking, and clapping). In 1974, Paul Fraisse defined rhythmic behavior as a periodic movement that obeys a temporal program specific to the subject and that depends less on the conditions of the action (p. 47). Among spontaneous rhythms, the spontaneous motor tempo (SMT) corresponds to the tempo at which someone produces movements in the absence of external stimuli, at the most regular, natural, and pleasant rhythm for him/her. However, intra- and inter-individual differences exist in the SMT values. Even if several factors have been suggested to influence the SMT (e.g., the age of participants), we do not yet know which factors actually modulate the value of the SMT. In this context, the objectives of the present systematic review are (1) to characterize the range of SMT values found in the literature in healthy human adults and (2) to identify all the factors modulating the SMT values in humans. Our results highlight that (1) the reference value of SMT is far from being a common value of 600 ms in healthy human adults, but a range of SMT values exists, and (2) many factors modulate the SMT values. We discuss our results in terms of intrinsic factors (in relation to personal characteristics) and extrinsic factors (in relation to environmental characteristics). Recommendations are proposed to assess the SMT in future research and in rehabilitative, educative, and sport interventions involving rhythmic behaviors.

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Reaction time and rhythm of movement in Huntington's disease

Cited by 6 publications

References 22 publications

Deficits in temporal processing correlate with clinical progression in Huntington's disease

Deficits in temporal processing correlate with clinical progression in Huntington's disease

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Which factors modulate spontaneous motor tempo? A systematic review of the literature

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