The role of resveratrol in the regulation of cell metabolism – a review

Abstract

Moderate wine drinking is associated with reduced risk of cardiovascular, cerebrovascular and peripheral vascular disease, and reduced risk of cancer. This phenomenon is called the "French paradox", since it was observed for the first time in France--a country famous for its wine production. In the literature, the cardioprotective effect of wine is very well described and attributed mainly to contained therein resveratrol. Recently, it has been demonstrated that resveratrol extends the lifespan of yeast through activation of the SirT1 longevity gene, which is also responsible for the longevity caused by caloric restriction. Furthermore, resveratrol exhibits high biological activity, affecting cell structures and contributing to their protection. This paper summarizes the available reports on functional and molecular aspects of resveratrol, wines and grapes as a result of the activation of longevity genes.

Melatonin reverses H2O2‐induced senescence in SH‐SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF‐κB

“…Furthermore, the specific connections between these different manipulations and the induction of autophagy are currently under intensive investigation. In the case of deacetylating sirtuins, the polyphenol resveratrol, an activator of SIRT1 that promotes lifespan in numerous organisms, is also a potent macroautophagy activator …”

Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum

“…Currently, resveratrol has attracted attention of researchers for its antitumor effect in a variety of human cancer cell lines through the regulation of various molecular targets [11]. Its antitumor roles cover almost all aspects of cancer, including tumor cell proliferation, invasion, metastasis, apoptosis [7], immunity [12], metabolism [13], and intestinal flora [14] (Figure 2).…”

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

“…This substance belongs to polyphenols, which are compounds produced by plants, and the highest concentrations can be found in blueberries, blackberries, mulberry fruit, and red grapes. Among grapevines such as Vitis vinifera, Vitis labrusca, and Vitis rotundifolia, the resveratrol content in the skins and seeds can range between 50 and 100 µg/g [67]. Valuable sources of the described compound are also knotweed root, peanuts, and beverages such as wine and tea.…”