Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

Ting, Kang; Jones, Tia M.; Naddell, Clayton; Bacanamwo, Méthode; Calvert, John W.; Thompson, Winston E.; Bond, Vincent C.; Chen, Y. Eugene; Liu, Dong

doi:10.5966/sctm.2015-0177

Cited by 200 publications

(199 citation statements)

References 67 publications

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“…Besides, sonic hedgehog overexpressing exosome derived from CD34 + improve cardiac function . Likewise, sonic hedgehog overexpressing exosome derived from T‐lymphocyte induce neoangiogenesis by NO synthesis pathway stimulation . Although such studies are scarce particularly in cardiovascular disease the results are promising and it resting seems that EVs whether as therapeutic vectors or as therapeutic agents are a step forwards in cardiac cell therapy.…”

Section: Application Of Evs Derived From Mscs In Regenerative Medicinementioning

confidence: 99%

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

Nooshabadi¹,

Mardpour²,

Yousefi‐Ahmadipour³

et al. 2018

J of Cellular Biochemistry

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Mesenchymal stem cells (MSCs) are adult multipotent cells that due to their ability to homing to damaged tissues and differentiate into specialized cells, are remarkable cells in the field of regenerative medicine. It's suggested that the predominant mechanism of MSCs in tissue repair might be related to their paracrine activity. The utilization of MSCs for tissue repair is initially based on the differentiation ability of these cells; however now it has been revealed that only a small fraction of the transplanted MSCs actually fuse and survive in host tissues. Indeed, MSCs supply the microenvironment with the secretion of soluble trophic factors, survival signals and the release of extracellular vesicles (EVs) such as exosome. Also, the paracrine activity of EVs could mediate the cellular communication to induce cell-differentiation/self-renewal. Recent findings suggest that EVs released by MSCs may also be critical in the physiological function of these cells. This review provides an overview of MSC-derived extracellular vesicles as a hopeful opportunity to advance novel cell-free therapy strategies that might prevail over the obstacles and risks associated with the use of native or engineered stem cells. EVs are very stable; they can pass the biological barriers without rejection and can shuttle bioactive molecules from one cell to another, causing the exchange of genetic information and reprogramming of the recipient cells. Moreover, extracellular vesicles may provide therapeutic cargo for a wide range of diseases and cancer therapy.

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Section: Application Of Evs Derived From Mscs In Regenerative Medicinementioning

confidence: 99%

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

Nooshabadi¹,

Mardpour²,

Yousefi‐Ahmadipour³

et al. 2018

J of Cellular Biochemistry

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“…RNA analysis revealed that miRNAs were enriched in adipose‐derived stem cells (ASCs) released MVs, and an underlying mechanism of the pro‐angiogenesis may be the delivery of miR‐31 via MVs from ASCs to ECs. miR‐31 in MVs from ASCs contributed to the migration and tube formation of ECs by targeting and suppressing factor‐inhibiting HIF‐1 …”

Section: The Role Of Mvs Containing Specific Mirnas In Vascular Endotmentioning

confidence: 99%

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

Shu

Tan

Miao

et al. 2019

J Cellular Molecular Medi

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Many studies have shown that endothelial dysfunction is associated with a variety of cardiovascular diseases. The endothelium is one of the primary targets of circulating microvesicles. Besides, microRNAs emerge as important regulators of endothelial cell function. As a delivery system of microRNAs, microvesicles play an active and important role in regulating vascular endothelial function. In recent years, some studies have shown that microvesicles containing microRNAs regulate the pathophysiological changes in vascular endothelium, such as cell apoptosis, proliferation, migration and inflammation. These studies have provided some clues for the possible roles of microvesicles and microRNAs in vascular endothelial dysfunction‐associated diseases, and opened the door towards discovering potential novel therapeutic targets. In this review, we provide an overview of the main characteristics of microvesicles and microRNAs, summarizing their potential role and mechanism in endothelial dysfunction, and discussing the clinical application and existing problems of microvesicles for better translational applications.

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“…In addition to MVs from MSCs, MVs released from adiposederived stem cells have the same potential application in angiogenic therapy for ischemic diseases, as these MVs were able to increase the migration and tube formation of human umbilical vein endothelial cells [13]. During embryo development, embryonic stem cells (ESCs) employ MVs to communicate with trophoblasts and induce phenotypic change of trophoblasts [14].…”

Section: Intrinsic Function Of Stem Cell Derived Mvsmentioning

confidence: 99%

The Emerging Role of Cell-Derived Microvesicles in Stem Cell Research and Therapy

Jiang

Song

2017

JSRT

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Recently, there has been growing interest in cell-derived microvesicles (MVs) or extracellular vesicles (EV) due to their vital roles in inter-cellular communications and great potential of therapeutic applications. The mechanism behind these roles involves encapsulation of bioactive molecules from MV-producing cells and delivery to receipt cells nearby or at long distance through blood circulation. Proteins, mRNA, miRNA or even certain phospholipids can be bioactive molecules in different MVs that transfer signals from producing cells to receipt cells and change their fate. Stem cells can produce MVs which are able to enhance proliferation of target cells. Among them, MVs derived from mesenchymal stem cells are well studied and have been shown to have multiple therapeutic applications. As an emerging area, there are still more work needed to be done, including but not limited to MV body distribution and pharmacokinetics, before these existing biofunctions found in vitro can be translated to patients.

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Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

Cited by 200 publications

References 67 publications

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

The Emerging Role of Cell-Derived Microvesicles in Stem Cell Research and Therapy

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