Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis

Türkyılmaz, Esengül; Yıldırım, Melahat; Çendek, Büşra Demir; Baran, Pervin; Alışık, Murat; Dalgaci, Ferit; Yavuz, Ayşe Filiz

doi:10.1016/j.ejogrb.2016.02.027

Cited by 41 publications

(33 citation statements)

References 27 publications

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“…In their preliminary studies, they reported that increased thiol and decreased disulphide levels were associated with proliferated diseases, such as multiple myeloma and malignancies, whereas decreased thiol levels and increased disulphide levels were associated with degenerative diseases, such as diabetes, obesity, pneumonia and smoking. [30][31][32] However, our results showed that dynamic thiol disulphide homeostasis is associated with an increased shift to the reductive side as a proliferative manner, in women diagnosed with major depressive disorder. In our correlation analysis, we found a negative correlation between depression severity and plasma disulphide levels only in the patient group.…”

Section: Anadolu Psikiyatri Derg 2018; 19(2):135-142contrasting

confidence: 49%

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Baykan¹,

Durmaz²,

Baykan³

et al. 2018

Anadolu Psikiyatri Derg

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Section: Anadolu Psikiyatri Derg 2018; 19(2):135-142contrasting

confidence: 49%

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Baykan¹,

Durmaz²,

Baykan³

et al. 2018

Anadolu Psikiyatri Derg

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“…In their preliminary studies, they showed that plasma disulphide levels were higher in patients with degenerative diseases, such as diabetes, smoking, obesity, and pneumonia, and were lower in patients with proliferative diseases, such as multiple myeloma, colon cancer, and renal cancer. [36][37][38] We found lower disulphide levels in patients with FMS compared with the healthy controls. However, we did not observe any difference in total thiol levels between the two groups.…”

Section: Discussionmentioning

confidence: 58%

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Fidan

Alkan²,

Uğurlu

et al. 2017

Arch Rheumatol

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Objectives: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS). Patients and methods: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel automated method. Results: Serum disulphide levels were 14.7±3.4 µmol/L and 22.2±3.6 µmol/L in the FMS and control groups, respectively (p<0.001). Native thiol levels were 452.1±33.8 µmol/L and 433.5±37.6 µmol/L in the FMS and control groups, (p=0.015), while total thiol levels were 481.7±35.6 µmol/L and 477.5±38.9 µmol/L in the FMS and control groups, respectively (p=0.593). In the FMS group, disulphide/native thiol percent ratios and disulphide/ total thiol percent ratios were statistically significantly lower and native/total thiol percent ratios were statistically significantly higher than those of the control group. There were no correlations between serum thiol/disulphide profiles and pain scores & clinical variables in patients with FMS. Conclusion: Because of the decreased disulphide and increased native thiol levels, the thiol/disulphide balance has shifted to the reductive side. This metabolic disturbance may have a role in the pathogenesis of FMS.

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“…Active MPO levels were found to be decreased in the follicular fluid of endometriosis patients [26]. In menstrual fluid [27] and in peripheral blood [26][27][28], no significant difference was found in active MPO levels between women with and without endometriosis, but no report on total MPO levels was provided.…”

Section: Discussionmentioning

confidence: 96%

“…As a marker of inflammation, MPO might serve as a potential noninvasive biomarker of endometriosis [25]. Data regarding the MPO level in peripheral blood of endometriosis patients are relatively scarce and large sample datasets are lacking (n = 17; 38; 58) [26][27][28]. Furthermore, these studies investigated only the activity of MPO, but no total MPO levels [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

“…Data regarding the MPO level in peripheral blood of endometriosis patients are relatively scarce and large sample datasets are lacking (n = 17; 38; 58) [26][27][28]. Furthermore, these studies investigated only the activity of MPO, but no total MPO levels [26][27][28]. Therefore, our study was done in a large number of subjects (n = 333) to test the hypothesis that total, active, and specific levels of MPO are significantly altered in plasma of women with endometriosis compared to women without endometriosis.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Total, Active, and Specific Myeloperoxidase Levels in Women with and without Endometriosis

Waelkens

Peterse

et al. 2017

Gynecol Obstet Invest

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Myeloperoxidase (MPO) is a proinflammatory enzyme and a marker for neutrophil activation and oxidative stress. Since oxidative stress and inflammation are linked to the pathogenesis of endometriosis, we hypothesized that the total, active, and specific (active/total) MPO levels were significantly different in plasma of women with and without endometriosis. Samples were selected from our biobank from women with endometriosis (n = 212) and controls without endometriosis (n = 121) across the menstrual cycle. Total MPO plasma levels were measured by immunoassay and MPO activity by enzymatic assay. Total and active MPO levels did not differ significantly among endometriosis cases and controls, whereas the specific MPO activity was significantly lower in women with endometriosis than that in controls (p = 0.0159). After the subdivision of control patients into women with a normal pelvis and women with other benign gynecological disorders, a significant difference was observed only between women with endometriosis and women with other benign gynecological disorders (p = 0.0266). In conclusion, systemic MPO levels may not be suited as a single biomarker for endometriosis. Our data support the involvement of MPO in other gynecological disorders but do not provide any evidence for an association with endometriosis.

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Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis

Cited by 41 publications

References 27 publications

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Evaluation of Total, Active, and Specific Myeloperoxidase Levels in Women with and without Endometriosis

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