Onkozytom versus chromophobes Nierenkarzinom

Lüders, Christine; Kristiansen, Glen

doi:10.1007/s00292-016-0145-0

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Today, it is clear that the amount and staining pattern of CK7 positive cells is important for the interpretation of CK7. Some authors even suggested to designate CK7 as negative, even when up to 10% of cells express weakly CK7 35 . Other authors state that < 5% CK7 expression is most suggestive of oncocytoma while a negative CK7 staining result is less uniformly considered supportive 3 .…”

Section: Discussionmentioning

confidence: 99%

Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy

Kriegsmann¹,

Casadonte²,

Maurer³

et al. 2020

J. Cancer

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Background: While subtyping of the majority of malignant chromophobe renal cell carcinoma (cRCC) and benign renal oncocytoma (rO) is possible on morphology alone, additional histochemical, immunohistochemical or molecular investigations are required in a subset of cases. As currently used histochemical and immunohistological stains as well as genetic aberrations show considerable overlap in both tumors, additional techniques are required for differential diagnostics. Mass spectrometry imaging (MSI) combining the detection of multiple peptides with information about their localization in tissue may be a suitable technology to overcome this diagnostic challenge. Patients and Methods: Formalin-fixed paraffin embedded (FFPE) tissue specimens from cRCC (n=71) and rO (n=64) were analyzed by MSI. Data were classified by linear discriminant analysis (LDA), classification and regression trees (CART), k-nearest neighbors (KNN), support vector machine (SVM), and random forest (RF) algorithm with internal cross validation and visualized by t-distributed stochastic neighbor embedding (t-SNE). Most important variables for classification were identified and the classification algorithm was optimized. Results: Applying different machine learning algorithms on all m/z peaks, classification accuracy between cRCC and rO was 85%, 82%, 84%, 77% and 64% for RF, SVM, KNN, CART and LDA. Under the assumption that a reduction of m/z peaks would lead to improved classification accuracy, m/z peaks were ranked based on their variable importance. Reduction to six most important m/z peaks resulted in improved accuracy of 89%, 85%, 85% and 85% for RF, SVM, KNN, and LDA and remained at the level of 77% for CART. t-SNE showed clear separation of cRCC and rO after algorithm improvement. Conclusion: In summary, we acquired MSI data on FFPE tissue specimens of cRCC and rO, performed classification and detected most relevant biomarkers for the differential diagnosis of both diseases. MSI data might be a useful adjunct method in the differential diagnosis of cRCC and rO.

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Section: Discussionmentioning

confidence: 99%

Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy

Kriegsmann¹,

Casadonte²,

Maurer³

et al. 2020

J. Cancer

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“…119 Yet words and images could not do justice to this experience, Lüders explained: "The cheers of the crowd, the smoke of the hundreds of chimneys, the choirs aboard several ships, the fluttering pennants, the rough Elbe, all of this developed into an impression that no participant will forget." 120 Twenty-year-old Harry Graf Kessler watched the emperor from the deck of a steamer next to the railway bridge. As he noted in his diary, Wilhelm II "came at about two; he stood on the captain's deck with Moltke, looking very straight and well, and a number of other officials; the sight of the crowd of launches and steamers on the Elbe, the crowd of people on the shore, the sea of heads, the deafening hurrahs, was most grand.…”

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confidence: 99%

An Imperial Adventus into a City of Warehouses: History, Modernity, and Urbanity in the Symbolic and Material Construction of Hamburg's Free Port

Heerten

2024

Cent Eur Hist

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The article analyzes the contemporary material, political, and symbolic construction of Hamburg's free port, zooming in on its festive opening in 1888, when Kaiser Wilhelm II visited to perform this ceremonious act. Asking why the “Speicherstadt” (warehouse city) was right away dubbed a “city” even though this was an exclusively commercial space devoid of inhabitants, the article uses this case study to argue that process concepts like “urbanization” frame our perspectives in ways that eclipse how older ideas about urbanity still defined a late-nineteenth-century political imaginary. The article shows how the opening ceremony, staged as an imperial adventus, alongside the “Speicherstadt's” neo-Gothic red-brick architecture, made recourse to established cultural forms that historians and other commentators often deem premodern. To counteract the prospect that port expansion could turn Hamburg into a working-class city, Hamburg's bourgeois merchant elite tried to construct the free port as a global urban bourgeois space embodying the city's history and its longevity as a space of urban trade privilege. The latter had erstwhile been defined by Hamburg's city walls, which, as the article argues, were symbolically rebuilt in the form of the Speicherstadt. The latter was the “city” into which this modern-day imperial adventus led.

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Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms

Zhu

Rohan

Lin

2020

Cancer Cytopathology

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BACKGROUND: The goal of this study was to evaluate the morphology, immunoprofile, and management of renal oncocytoma (RO), hybrid oncocytic tumor (HOT), and chromophobe renal cell carcinoma (ChRCC). METHODS: Forty-seven cases of RO, 7 cases of HOT, and 25 cases of ChRCC were included in the study. Tissue microarrays were prepared for immunohistochemical evaluation. RESULTS: Large sheets of cells with transverse vessels, and higher nuclear grade were seen more often in ChRCC than in RO or HOT. Tumor cells of RO were more uniform in size and shape relative to HOT and ChRCC. The cytoplasmic features of RO were more uniformly granular relative to HOT and ChRCC, which exhibited variable cytoplasmic features. CK7 and MUC1 were expressed more frequently and diffusely in ChRCC (54% and 94%, respectively) than RO (4% and 52%, respectively) and HOT (0% and 71%, respectively). AMACR and PAX8 were more frequently expressed diffusely in RO (67% and 42%, respectively) than in HOT (0% and 0%, respectively) or ChRCC (14% and 11%, respectively). Most HOT (57%) and CHRCC (60%) patients underwent nephrectomy. Cryoablation was the treatment of choice for 24% of patients with ChRCC, 2% of patients with RO, and 0% of patients with HOT. The majority of patients with RO (88%) opted for active surveillance-a much higher rate than that for patients with HOT (29%) or ChRCC (12%). CONCLUSION: Some cytologic features and immunomarkers are useful in differentiating RO, HOT, and ChRCC. Because no immunomarker or morphologic finding is specific by itself, a combination of morphologic features with immunohistochemistry appears to be the most reliable way to distinguish ChRCC, HOT, and RO on biopsy samples. Subclassification of renal oncocytic tumors into specific categories impacts clinical management and downstream treatment selection.

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Onkozytom versus chromophobes Nierenkarzinom

Cited by 7 publications

References 20 publications

Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy

Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy

An Imperial Adventus into a City of Warehouses: History, Modernity, and Urbanity in the Symbolic and Material Construction of Hamburg's Free Port

Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms

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