Thermofusion of the retina with the RPE to seal tears during retinal detachment repair

Heriot, Wilson

doi:10.1007/s00417-016-3295-0

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…RRD is a common ophthalmological disease that usually affects middle-aged men with myopia (6,7). RRD prevents the outer retina layer from obtaining nutrition from choroid, which may lead to atrophy of the detached retina and its subsequent degeneration (8,9). Untreated RRD may lead to impairment or loss of vision, and recovery is unlikely (10).…”

Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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Rhegmatogenous retinal detachment (RRD) is a disorder of the eye that affects physical and mental health. Retinal pigment epithelium (RPE) is closely associated with RRD, and it is hypothesized that RPE-secreted inflammatory cytokines may induce early pathological changes of RRD and may participate in RPE proliferation and migration. The present study determined a role for interleukin (IL)‑10 as an RPE‑secreted immune regulatory factor that contributes to RRD. A rat RRD model was established and RPE cells were isolated and cultivated. RPE cells were randomly divided into four groups, three treated with different concentrations of IL‑10 (100, 50, and 20 mM) and one untreated. RPE cell proliferation was evaluated by MTT assay and the activity of caspase‑3 was also measured. RPE cell invasion was determined by Transwell assay. Vascular endothelial growth factor A (VEGF) expression was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting; IL‑1 and IL‑6 levels were measured by ELISA. IL‑10 treatment suppressed RPE cell proliferation and migration, promoted caspase‑3 activity, inhibited VEGF mRNA and protein expression, and downregulated the secretion of inflammatory cytokines IL‑1 and IL‑6 in RRD group compared with the untreated Model group. The aforementioned effects of IL‑10 became more evident with increasing IL‑10 concentration. IL‑10 suppressed inflammation, facilitated RPE cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression.

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Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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“…Our preliminary study shows that the laser at the settings we employed (100-150 mW, 120 and 200 ms) while achieving proper chori-oretinal adhesion around the break (bonding the two tissues like a glue), results in reduced retinal damage. Furthermore, the retinal thickness remained normal in direct RPE laser photocoagulation while reduced by almost two-thirds in the traditional transretinal laser treatment area, where the fusion is achieved by a thermal effect [16]. Since glial and RPE cells may play an important role in the closure of retinal break [17], preserving the integrity to the extent possible of both the neuroretina and RPE may enhance the formation of the seal.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to a complete vitrectomy, attention was paid to removing all traction forces [18] during surgery. Nevertheless, retinectomy was still necessary in 11 eyes due to various factors such as retinal shortening such as in eyes with high axial length [16,18,19] or proliferative tissues prove impossible to separate from the retina [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Direct Laser Photocoagulation of the Retinal Pigment Epithelium: A Novel Method to Seal Retinal Breaks during Pars Plana Vitrectomy for Retinal Detachment

Du,

Yang,

Zha

et al. 2023

Discovery Medicine

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Background: This study evaluates the clinical effectiveness of employing direct retinal pigment epithelium (RPE) laser photocoagulation as a technique for achieving chorioretinal adhesion to effectively seal retinal breaks. Methods: A total of 20 eyes from 20 patients were enrolled in the study; all selected eyes exhibited either rhegmatogenous or combined rhegmatogenous-tractional retinal detachment. During vitrectomy, direct RPE laser photocoagulation was executed, employing a power range of 100-150 mW and a duration of 120-200 ms, targeting the peripheries where the edges of each retinal break were anticipated to settle post-reattachment. This treated area's neuroretina thickness was compared to measurements obtained after conventional transretinal laser photocoagulation. Results: Patients were followed for an average duration of 24 months, with a range of 11-46 months. A visible pigmentary reaction in the ophthalmoscopic examination was evident in the treated regions for all but one eye, where the retinal break was situated amidst myelinated nerve fibers. The study encountered no severe complications, and successful retinal reattachment was achieved in all 20 eyes. The mean best-corrected visual acuity (BCVA) at the final follow-up showed a statistically significant improvement compared to preoperative levels (p < 0.0001). A noteworthy difference in neuroretinal thickness was observed one-month post-surgery between areas treated with direct RPE and those treated with transretinal photocoagulation, measuring 217 µm and 104 µm, respectively. Conclusions: Our findings suggest that direct RPE laser photocoagulation is an effective therapeutic intervention for sealing retinal breaks.

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“…In addition to performing a vitrectomy as complete as possible, we paid particular attention to the removal of all traction forces [22] during surgery; yet retinectomy was still necessary in 11 eyes, due to retinal shortening such as in eyes with high axial length [20,22,23] or proliferative tissues that prove impossible to separate from the retina [24][25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Direct Laser Photocoagulation of the Retinal Pigment Epithelium: A Novel Method to Seal Retinal Breaks during Pars Plana Vitrectomy for Retinal Detachment

Du,

Yang,

Zha

et al. 2023

Preprint

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Aims: To examine the clinical effectiveness of employing direct retinal pigment epithelium (RPE) laser photocoagulation to create chorioretinal adhesion around the retinal breaks. Methods: Twenty eyes of 20 patients were included in the study; all eyes had rhegmatogenous or combined rhegmatogenous-tractional retinal detachment. Direct RPE laser photocoagulation during vitrectomy, using power of 100-150 mw for of 120-200 ms duration, was performed in the area where the edges of each retinal break would settle following retinal reattachment. The thickness of the neuroretina over the treated area was compared to that measured after traditional transretinal laser photocoagulation. Results: The mean follow-up time was 24 (11-46) months. Postoperatively, an ophthalmoscopically visible pigmentary reaction developed over the treated area, except for a single eye where the retinal break was located in an area of myelinated nerve fibres. There were no serious complications, and the retinas in all 20 eyes remained reattached. The mean best-corrected visual acuity (BCVA) at the final follow-up was significantly higher than that before surgery (p=0.001). The thickness of the neuroretina at 1 month after surgery greatly differed between areas of direct versus transretinal laser photocoagulation: 217 μm in the former and 104 μm in the latter group. Conclusions: The efficacy of direct RPE photocoagulation in retinal break sealing equals the effect of traditional transretinal photocoagulation, but without risking damaging the neurosensory retina, and the laser application is not hindered by retinal opacities.

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Thermofusion of the retina with the RPE to seal tears during retinal detachment repair

Cited by 9 publications

References 12 publications

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Direct Laser Photocoagulation of the Retinal Pigment Epithelium: A Novel Method to Seal Retinal Breaks during Pars Plana Vitrectomy for Retinal Detachment

Direct Laser Photocoagulation of the Retinal Pigment Epithelium: A Novel Method to Seal Retinal Breaks during Pars Plana Vitrectomy for Retinal Detachment

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