Macrocyclic Gadolinium-Based Contrast Agents Do Not Cause Hyperintensity in the Dentate Nucleus

Kanda, Tomonori; Oba, Hiroshi; Toyoda, Keiko; Furui, S

doi:10.3174/ajnr.a4710

Cited by 18 publications

(11 citation statements)

References 7 publications

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“…Moreover, a substantially larger dose of CA per MR imaging session was injected in the macrocyclic GBCAs group compared to the linear GBCAs one. Also, as reported by Kanda et al in 2015 [34], tissues concentrations of elemental gadolinium resulting from linear GBCAs were between 2.5 and 4 times higher to equivalent intravenous macrocyclic GBCAs doses [35]- [43]. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59…”

Section: Article Body Templatesupporting

confidence: 64%

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

et al. 2019

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MRI has been recognized as one of the most applied medical imaging techniques in clinical practice. However, the presence of background signal coming from water protons in surrounding tissues makes sometimes the visualization of local contrast agents difficult. To remedy this, fluorine has been introduced as a reliable perspective, thanks to its magnetic properties being relatively close to those of protons. In this review, we aim to give an overall description of fluorine incorporation in contrast agents for MRI. The different kinds of fluorinated probes such as perfluorocarbons, fluorinated dendrimers, polymers and paramagnetic probes will be described, as will their imaging applications such as chemical exchange saturation transfer (CEST) imaging, physico-chemical changes detection, drug delivery, cell tracking and inflammation or tumors detection.

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Section: Article Body Templatesupporting

confidence: 64%

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

et al. 2019

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“…However, in that study a greater decrease was determined in gadoteric acid accumulation in liver tissue compared to gadodiamide after the first day, and gadodiamide accumulation was subsequently greater than that of gadoteric acid . In the light of data from recent studies, and in contrast to earlier research, it does not now seem possible to generalize about accumulation in tissues by classes of gadolinium . Some contrast agents (linear agents) were first reported to cause nephrogenic systemic sclerosis only in subjects with kidney failure .…”

Section: Discussionmentioning

confidence: 77%

“…31 In the light of data from recent studies, and in contrast to earlier research, it does not now seem possible to generalize about accumulation in tissues by classes of gadolinium. 8,[31][32][33] Some contrast agents (linear agents) were first reported to cause nephrogenic systemic sclerosis only in subjects with kidney failure. 34 However, recent studies have reported gadolinium accumulation from the same contrast group in various tissues, particularly the liver and spleen, in subjects without kidney failure.…”

Section: Discussionmentioning

confidence: 99%

Effects of gadolinium‐based MRI contrast agents on liver tissue

Mercantepe

Tümkaya

Çeliker

et al. 2018

Magnetic Resonance Imaging

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“…Previous studies that examined the association between gadolinium retention in the brain and changes in signal intensity on T1-weighted images predominantly focused on the adult population, with multiple investigators suggesting that these changes in signal intensity are entirely due to gadolinium deposition (2,15,16,(22)(23)(24)(25)(26). Although there are substantially fewer reported studies involving pediatric patients, similar findings of increased signal intensity on T1-weighted images in the deep nuclei with use of linear GBCAs have been reported (14,(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 83%

Brain Irradiation and Gadobutrol Administration in Pediatric Patients with Brain Tumors: Effect on MRI Brain Signal Intensity

et al. 2018

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Purpose To determine whether treatment affects MRI signal intensity in pediatric patients with primary brain tumors independent of the administration of macrocyclic gadolinium-based contrast agents (GBCAs). Materials and Methods This retrospective, single-center study included 78 patients (mean age, 7.7 years ± 5.4) with primary brain tumors who underwent macrocyclic GBCA-enhanced MRI from 2015 to 2018. Three groups were compared: (a) patients who had undergone radiation therapy (37 patients, 26 of whom had undergone concurrent chemotherapy), (b) patients who had undergone chemotherapy only (17 patients), and (c) patients who had received no treatment ("no-treatment group," 24 patients). The signal intensity in the globus pallidus (GP), thalamus, dentate nucleus (DN), and pons was measured on unenhanced T1-weighted images. GP-to-thalamus and DN-to-pons signal intensity ratios were compared among groups with analysis of variance by using the Kruskal-Wallis test, followed by post hoc pairwise tests with Tukey adjustment, and were analyzed relative to group, total cumulative doses of GBCA, age, and sex with multivariable linear models. Results The mean number of GBCA-enhanced MRI examinations in the radiation therapy, chemotherapy-only, and no-treatment groups was 7.11, 7.29, and 4.96, respectively (P < .01 for the radiation therapy and chemotherapy groups compared with the no-treatment group). The DN-to-pons ratio in the radiation therapy group was higher than that in both the no-treatment group and the chemotherapy-only group (P < .01 for both). There was no significant difference in the DN-to-pons ratios between the chemotherapy-only group and the no-treatment group (P = .99). The GP-to-thalamus ratios did not differ among all three groups (P = .09). There was no dose-dependent effect of GBCA on the DN-to-pons and GP-to-thalamus ratios when adjusting for the effects of treatment (P = .21 and P = .38, respectively). Conclusion Brain irradiation contributes to a higher dentate nucleus signal intensity in pediatric patients with brain tumor independent of the administration of macrocyclic gadolinium-based contrast agents. © RSNA, 2018.

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Macrocyclic Gadolinium-Based Contrast Agents Do Not Cause Hyperintensity in the Dentate Nucleus

Cited by 18 publications

References 7 publications

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

Effects of gadolinium‐based MRI contrast agents on liver tissue

Brain Irradiation and Gadobutrol Administration in Pediatric Patients with Brain Tumors: Effect on MRI Brain Signal Intensity

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