Association between bullous pemphigoid and hypovitaminosis D in older inpatients: Results from a case–control study

Sarre, M.E.; Annweiler, Cédric; Legrand, Érick; Martin, Ludovic; Beauchet, Olivier

doi:10.1016/j.ejim.2016.02.004

Cited by 14 publications

(14 citation statements)

References 20 publications

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“…Several epidemiological studies demonstrated that the vitamin D deficiency leads to an increased prevalence of autoimmune diseases, such as the multiple sclerosis, diabetes type 1, rheumatoid arthritis or systemic lupus erythematosus (Yang et al, 2013, Dankers et al, 2017. More recently, the role of vitamin D has been also investigated in AIBD and the emerging evidence suggests an increased frequency of vitamin D deficiency/insufficiency in patients with pemphigus and pemphigoid, such as the PV and BP or EBA, respectively (Marzano et al, 2012 andMarzano et al, 2015;Tukaj et al, 2013;El-Komy et al, 2014;Joshi et al, 2014;Zarei et al, 2014;Moravvej et al, 2016;Sarre et al, 2016;Tukaj et al, 2018) (Table 1). In addition, in some reports, lower concentrations of 25(OH)D have been associated with AIBD activity, pointing towards a possible causative role of hypovitaminosis D in the disease process (Zarei et al, 2014;Marzano et al, 2015;Moravvej et al, 2016).…”

Section: Vitamin D Status In the Autoimmune Bullous Diseasesmentioning

confidence: 99%

“…In addition, in some reports, lower concentrations of 25(OH)D have been associated with AIBD activity, pointing towards a possible causative role of hypovitaminosis D in the disease process (Zarei et al, 2014;Marzano et al, 2015;Moravvej et al, 2016). The role of vitamin D deficiency in AIBD, however, is still a matter of debate because other studies have found no difference in the 25(OH)D levels between patients and healthy subjects, possibly due to concomitantly observed low vitamin D levels in the corresponding controls and/ or limited number of patients and controls involved in the study (Tukaj et al, 2013;Joshi et al, 2014;Moravvej et al, 2016;Sarre et al, 2016).…”

Section: Vitamin D Status In the Autoimmune Bullous Diseasesmentioning

confidence: 99%

“…Moreover, several clinical trials have been performed to investigate the therapeutic value of vitamin D supplementation in multiple sclerosis, rheumatoid arthritis, Crohn's disease, type I diabetes, and systemic lupus erythematosus (Dankers et al, 2017). While patients with the autoimmune bullous skin diseases suffer from vitamin D deficiency (Marzano et al, 2012and Marzano et al, 2012Tukaj et al, 2013;El-Komy et al, 2014;Joshi et al, 2014;Zarei et al, 2014;Moravvej et al, 2016;Sarre et al, 2016;Tukaj et al, 2018), a direct link between hypovitaminosis D and the development of autoimmune bullous diseases has not been proven.…”

Section: Experimental Therapies Using Vitamin D Analogues In the Automentioning

confidence: 99%

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Vitamin D in autoimmune bullous disease

Tukaj

2020

Acta Biochim Pol

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Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organ-specific group of inflammatory skin diseases characterized by the presence of tissue-bound and circulating autoantibodies against various molecules present in desmosomes (in pemphigus diseases) or hemidesmosomes (in pemphigoid diseases). In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system. Since cells of both, the innate and adaptive immune systems, are known to be relevant in AIBD, the role of vitamin D analogues in the treatment of patients with these disorders deserves much attention. This mini-review summarizes recent epidemiological and experimental studies on vitamin D involvement in the autoimmune bullous diseases.

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Section: Vitamin D Status In the Autoimmune Bullous Diseasesmentioning

confidence: 99%

Section: Vitamin D Status In the Autoimmune Bullous Diseasesmentioning

confidence: 99%

Section: Experimental Therapies Using Vitamin D Analogues In the Automentioning

confidence: 99%

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Vitamin D in autoimmune bullous disease

Tukaj

2020

Acta Biochim Pol

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“…Hypovitaminosis D can thus result in immune dysregulation and is associated with an increased prevalence of autoimmune diseases . Notably, pemphigoid patients have hypovitaminosis D which correlates with increased disease severity . In preclinical trials, mice receiving prophylactic oral calcitriol experienced milder skin lesions and histologically less intense dermal infiltration of neutrophils .…”

Section: Evolving Therapeutic Targetsmentioning

confidence: 99%

“…[209][210][211] Notably, pemphigoid patients have hypovitaminosis D which correlates with increased disease severity. 212 In preclinical trials, mice receiving prophylactic oral calcitriol experienced milder skin lesions and histologically less intense dermal infiltration of neutrophils. 213 Mechanistically, calcitriol impeded neutrophil recruitment and activation by Gr-1+ myeloid cells in addition to hindering IC-mediated ROS release.…”

Section: Heat Shock Protein 90 Inhibitionmentioning

confidence: 99%

From bench to bedside: evolving therapeutic targets in autoimmune blistering disease

Kridin

Kowalski

Kneiber

et al. 2019

Acad Dermatol Venereol

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Autoimmune blistering diseases comprise a group of heterogenous conditions characterized by the loss of tolerance and subsequent development of autoantibodies targeting epidermal and subepidermal adhesion proteins. Blisters and erosions form on the skin and mucous membranes leading to significant morbidity and mortality. Traditional therapies rely on systemic immunosuppression. Advancements in our understanding of the pathophysiology of pemphigus and pemphigoid have led to the development of molecules which target specific pathways involved in induction and perpetuation of disease. In this review, we outline the novel therapeutic strategies including B‐cell depletion, T‐regulatory cell repletion, cell signalling inhibitors and small molecular inhibitors, inhibitory monoclonal antibodies, as well as complement inhibition. We additionally review their current level of clinical evidence. We lastly review therapeutics targets gleaned from the experimental epidermolysis bullosa acquisita mouse model. These emerging treatments offer an exciting progression from basic science discoveries that have the potential to transform the treatment paradigm in autoimmune blistering diseases.

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A systematic review of vitamin D status in southern European countries

et al. 2017

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Contrary to expectations, there was a high prevalence of low vitamin D status in the Southern Europe and the Eastern Mediterranean regions, despite abundant sunshine. These data further emphasize the need for strategies, such as fortification of foods with vitamin D and/or vitamin D supplementation, which will be tailored to the needs of specific population groups with higher risk of insufficiency or deficiency, to efficiently tackle the pandemic of hypovitaminosis D in Europe.

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Association between bullous pemphigoid and hypovitaminosis D in older inpatients: Results from a case–control study

Cited by 14 publications

References 20 publications

Vitamin D in autoimmune bullous disease

Vitamin D in autoimmune bullous disease

From bench to bedside: evolving therapeutic targets in autoimmune blistering disease

A systematic review of vitamin D status in southern European countries

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