Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

Jagannath, Vanitha A; Asokan, G V; Fedorowicz, Zbys; Lee, Tim W. R.

doi:10.1002/14651858.cd008139.pub4

Cited by 7 publications

(1 citation statement)

References 29 publications

(17 reference statements)

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“… 7 During influenza season, our center prescribes neuraminidase inhibitors for patients exhibiting symptoms of influenza infection, although there is no specific evidence in people with CF. 19 …”

Section: Defining An Apementioning

confidence: 99%

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation

Muirhead

Sanford

McCullar

et al. 2016

Clin Med Insights Pediatr

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Cystic fibrosis (CF) is a chronic disorder characterized by acute pulmonary exacerbations that comprise increased cough, chest congestion, increased mucus production, shortness of breath, weight loss, and fatigue. Typically, severe episodes are treated in the inpatient setting and include intravenous antimicrobials, airway clearance therapy, and nutritional support. Children with less-severe findings can often be managed as outpatients with oral antimicrobials and increased airway clearance therapy at home without visiting the specialty CF center to begin treatment. Selection of specific antimicrobial agents is dependent on pathogens found in surveillance culture, activity of an agent in patients with CF, and the unique physiology of these patients. In this pediatric review, we present our practice for defining acute pulmonary exacerbation, deciding treatment location, initiating treatment either in-person or remotely, determining the frequency of airway clearance, selecting antimicrobial therapy, recommending timing for follow-up visit, and recognizing and managing treatment failures.

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Section: Defining An Apementioning

confidence: 99%

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation

Muirhead

Sanford

McCullar

et al. 2016

Clin Med Insights Pediatr

View full text Add to dashboard Cite

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Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

Jagannath¹,

Asokan

Fedorowicz

et al. 2016

Cochrane Database of Systematic Reviews

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Treatment of pulmonary exacerbations in cystic fibrosis

Nadig

Smyth

et al. 2020

Current Opinion in Pulmonary Medicine

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Purpose of review: This review will discuss the challenges of defining a pulmonary exacerbations in cystic fibrosis (CF) and the key pathogens which contribute. It will discuss the treatment options currently available and the importance of preventing pulmonary exacerbations. Recent findings:The basis for treatment of pulmonary exacerbations remains unchanged over the past 15 years and whilst there have been trials exploring alternative antibiotics, there has been little change. However, there are ongoing studies that are expected to establish a platform for identifying best practices. Chronic CF therapies have been shown to reduce pulmonary exacerbations. In the era of new CFTR (CF transmembrane conductance regulator) modulator therapies, the number of pulmonary exacerbations are expected to be even fewer. However, it is unclear whether the other chronic therapies can be discontinued without losing their benefits in reducing exacerbations. Summary:Although there is no universal definition of a pulmonary exacerbation in CF, proposed definitions have many similarities. We have outlined the current recommendations for treatment of pulmonary exacerbations, including the duration and location of treatments. We have also summarised the key therapies used for prevention of pulmonary exacerbations in CF.

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Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

Abstract: Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis (Review)

Cited by 7 publications

References 29 publications

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

Treatment of pulmonary exacerbations in cystic fibrosis

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